scholarly journals Dynamic Selection for Service Composition Based on Temporal and QoS Constraints

2016 ◽  
Author(s):  
Ikbel Guidara ◽  
Imane Al Jaouhari ◽  
Nawal Guermouche
Keyword(s):  
Service Composition ◽  
Dynamic Selection ◽  
Selection For

Combining localized fusion and dynamic selection for high-performance SVM

2015 ◽  
Vol 42 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Jun-Ki Min ◽  
Jin-Hyuk Hong ◽  
Sung-Bae Cho
Keyword(s):  
High Performance ◽  
Dynamic Selection ◽  
Selection For

scholarly journals Building reusable phage and antibiotic treatments via exploitation of bacteria-phage coevolutionary dynamics.

2021 ◽  
Author(s):  
James Gurney ◽  
Sam P Brown
Keyword(s):  
Phage Therapy ◽  
Treatment Options ◽  
Arms Race ◽  
Evolutionary Dynamic ◽  
Fluctuating Selection ◽  
Dynamic Selection ◽  
Selection Dynamics ◽  
Genomic Characterization ◽  
Selection For

People with chronic (long-lasting) infections face the problem that treatment options diminish in time as the pathogen evolves increasing resistance. To address this challenge, we exploit phage and bacterial co-evolution, producing dynamic selection pressures that can return the pathogen to a state of susceptibility to the initial (regulator-approved) therapy. We show that phage OMKO1 alone triggers Arms Race Dynamic (ARD) co-evolution with the pathogen Pseudomonas aeruginosa, leading to generalized phage resistance and crucially - failure at reuse. In contrast, co-administration of the phage with antibiotics triggers Fluctuating Selection Dynamics (FSD) co-evolution, allowing for effective reuse after 20 days of treatment. We pursue medical relevance in our experiments with the use of clinically important pathogens, antibiotics, phage, and a benchmarked synthetic sputum medium. Phenotypic and genomic characterization of evolved isolates demonstrates that efflux-targeting phage OMKO1 exerts continued selection for antibiotic susceptibility regardless of co-evolutionary dynamic or antibiotic co-treatment, opening the door for evolutionary robust phage therapy.

scholarly journals CMBF-based dynamic selection for heterogeneous massive MIMO systems

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Yinghui Zhang ◽  
Biao Zhang ◽  
Yifan Mu ◽  
Kun Song ◽  
Jing Gao ◽  
...  
Keyword(s):  
Massive Mimo ◽  
Mimo Systems ◽  
Dynamic Selection ◽  
Selection For
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