Extra-Virgin Olive Oil and Oleocanthal Reduce Amyloid ß Load in Alzheimer's Disease Mouse Model

2016 ◽  
Author(s):  
Yazan Batarseh ◽  
Hisham Qosa ◽  
Khalid Elsayed ◽  
Jeffrey N. Keller ◽  
Amal Kaddoumi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil

scholarly journals Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Joaquín G. Cordero ◽  
Ramón García-Escudero ◽  
Jesús Avila ◽  
Ricardo Gargini ◽  
Vega García-Escudero
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Autophagy Gene ◽  
Potential Benefits ◽  
And Oxidative Stress

Alzheimer’s disease is a proteinopathy characterized by accumulation of hyperphosphorylated Tau and β-amyloid. Autophagy is a physiological process by which aggregated proteins and damaged organelles are eliminated through lysosomal digestion. Autophagy deficiency has been demonstrated in Alzheimer’s patients impairing effective elimination of aggregates and damaged mitochondria, leading to their accumulation, increasing their toxicity and oxidative stress. In the present study, we demonstrated by microarray analysis the downregulation of fundamental autophagy and mitophagy pathways in Alzheimer’s patients. The benefits of the Mediterranean diet on Alzheimer’s disease and cognitive impairment are well known, attributing this effect to several polyphenols, such as oleuropein aglycone (OLE), present in extra virgin olive oil. OLE is able to induce autophagy, achieving a decrease of aggregated proteins and a reduction of cognitive impairment in vivo. This effect is caused by the modulation of several pathways including the AMPK/mTOR axis and the activation of autophagy gene expression mediated by sirtuins and histone acetylation or EB transcription factor. We propose that supplementation of diet with extra virgin olive oil might have potential benefits for Alzheimer’s patients by the induction of autophagy by OLE.

Restoration of BMI1 levels after the administration of early harvest extra virgin olive oil as a therapeutic strategy against Alzheimer's disease

2021 ◽  
Vol 144 ◽  
pp. 111178
Author(s):  
Elena E. Tzekaki ◽  
Angelos Papaspyropoulos ◽  
Magda Tsolaki ◽  
Eftychia Lazarou ◽  
Mahi Kozori ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Olive Oil ◽  
Therapeutic Strategy ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Early Harvest
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