Soft Tissue Engineering In Vivo with PGLA Scaffolds and PLGA/PEG Microsphere Long Term Delivery of Lipogenic Factors

2005 ◽  
Author(s):  
E. Yuksel ◽  
R. Ray ◽  
S. Wamsley ◽  
A. Weinfeld ◽  
J. Waugh ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Term Delivery ◽  
Soft Tissue Engineering

Biodegradable polyurethane/graphene oxide scaffolds for soft tissue engineering: in vivo behavior assessment

2019 ◽  
Vol 69 (17) ◽  
pp. 1101-1111 ◽  
Author(s):  
Aleksandra Ivanoska-Dacikj ◽  
Gordana Bogoeva-Gaceva ◽  
Andres Krumme ◽  
Elvira Tarasova ◽  
Chiara Scalera ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Soft Tissue ◽  
Behavior Assessment ◽  
Biodegradable Polyurethane ◽  
Soft Tissue Engineering

scholarly journals 4D polycarbonates via stereolithography as scaffolds for soft tissue repair

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Andrew C. Weems ◽  
Maria C. Arno ◽  
Wei Yu ◽  
Robert T. R. Huckstepp ◽  
Andrew P. Dove
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Healing Process ◽  
Surface Erosion ◽  
Tissue Engineering Scaffolds ◽  
Adipose Tissue Engineering ◽  
Filling Materials ◽  
Aliphatic Polycarbonate ◽  
Soft Tissue Engineering

Abstract3D printing has emerged as one of the most promising tools to overcome the processing and morphological limitations of traditional tissue engineering scaffold design. However, there is a need for improved minimally invasive, void-filling materials to provide mechanical support, biocompatibility, and surface erosion characteristics to ensure consistent tissue support during the healing process. Herein, soft, elastomeric aliphatic polycarbonate-based materials were designed to undergo photopolymerization into supportive soft tissue engineering scaffolds. The 4D nature of the printed scaffolds is manifested in their shape memory properties, which allows them to fill model soft tissue voids without deforming the surrounding material. In vivo, adipocyte lobules were found to infiltrate the surface-eroding scaffold within 2 months, and neovascularization was observed over the same time. Notably, reduced collagen capsule thickness indicates that these scaffolds are highly promising for adipose tissue engineering and repair.

scholarly journals Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mary Beth Wandel ◽  
Craig A. Bell ◽  
Jiayi Yu ◽  
Maria C. Arno ◽  
Nathan Z. Dreger ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Biological Tissues ◽  
Soft Tissue Regeneration ◽  
Soft Tissue Engineering ◽  
Degradation Properties ◽  
Enhance Cell Adhesion

AbstractComplex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.

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