The phase behavier and the physicochemical properties of mixed surfactants microemulsions as drug delivery systems

2011 ◽  
Author(s):  
Jiacheng Li ◽  
Shaofan Yu ◽  
Yuhong Feng ◽  
Qiang Lin ◽  
Xueqing Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Mixed Surfactants

scholarly journals Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1089 ◽  
Author(s):  
Chenyu Wang ◽  
Bozhong Lin ◽  
Haopeng Zhu ◽  
Fei Bi ◽  
Shanshan Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Boronic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
3D Structure ◽  
Three Dimensional ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Diabetes Therapy

Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked three-dimensional (3D) structure endows the glucose-sensitive gels with great physicochemical properties. The PBA-based platforms with cross-linked structures have found promising applications in self-regulated drug delivery systems. This article summarizes some recent attempts at the developments of PBA-mediated glucose-sensitive gels for self-regulated drug delivery. The PBA-based glucose-sensitive gels, including hydrogels, microgels, and nanogels, are expected to significantly promote the development of smart self-regulated drug delivery systems for diabetes therapy.

Nanocrystalline cellulose: Preparation, physicochemical properties, and applications in drug delivery systems

2019 ◽  
Vol 133 ◽  
pp. 850-859 ◽  
Author(s):  
Ansar Karimian ◽  
Hadi Parsian ◽  
Maryam Majidinia ◽  
Mahdi Rahimi ◽  
Seyed Mostafa Mir ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanocrystalline Cellulose

The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery

2019 ◽  
Vol 4 (3) ◽  
pp. 160-175 ◽  
Author(s):  
Salome A. Chime ◽  
Paul A. Akpa ◽  
Anthony A. Attama
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Drug Delivery Systems ◽  
Liquid Crystalline ◽  
Delivery Systems ◽  
Nano Drug Delivery ◽  
Polymorphic Forms ◽  
Lipid Excipients ◽  
Biopharmaceutics Classification ◽  
Crystalline Phase Transition

Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have been used to control the release of drugs and have utility for drug targeting and hence, have been used for the delivery of various anticancer drugs and for colon targeting. Drugs encapsulated in lipids have enhanced stability due to the protection they enjoy in the lipid core of these nanoformulations. However, lipid excipients could be influenced by factors which could affect the physicochemical properties of lipid-based drug delivery systems (LBDDS). These factors include the liquid crystalline phase transition, lipid crystallization and polymorphism amongst others. However, some of the physicochemical properties of lipids made them useful as nanocarriers in the formulation of various nanoformulations. Lipids form vesicles of bilayer which have been used to deliver drugs and are often referred to as liposomes and nanoliposomes. This work aims at reviewing the different classes of lipid excipients used in formulating LBDDS and nanoformulations. Also, some factors that influence the properties of lipids, different polymorphic forms in lipid excipients that made them effective nanocarriers in nano-drug delivery would be discussed. Special considerations in selecting lipid excipients used in formulating various forms of nanoformulations would be discussed.

scholarly journals RECENT ADVANCES IN ELASTIN-BASED BIOMATERIALS

2020 ◽  
Vol 23 ◽  
pp. 314-332
Author(s):  
María Luisa Del Prado Audelo ◽  
Néstor Mendoza-Muñoz ◽  
Lidia Escutia-Guadarrama ◽  
David Giraldo-Gomez ◽  
Maykel González-Torres ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Synthetic Polymers ◽  
Delivery Systems ◽  
The Other ◽  
Main Components ◽  
Similar Conformation

Elastin is one of the main components of the extracellular matrix; it provides resistance and elasticity to a variety of tissues and organs of the human body, besides participating in cellular signaling. On the other hand, elastin-derived peptides are synthetic biopolymers with a similar conformation and structure to elastin, but these possess the advantage of solubility in aqueous mediums. Due to their biological activities and physicochemical properties, elastin and related peptides may be applied as biomaterials to develop diverse biomedical devices, including scaffolds, hydrogels, and drug delivery systems for tissue engineering. Likewise, the combination of elastin with natural or synthetic polymers has demonstrated to improve the mechanical properties of biomedical products and drug delivery systems. Here we comprehensively describe the physicochemical properties and physiological functions of elastin. Moreover, we offer an overview of the use of elastin and its derivative polymers as biomaterials to develop scaffolds and hydrogels for tissue engineering. Finally, we discuss some perspectives on the employment of these biopolymers to fabricate new biomedical products.

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