Reliability and Availability modelling of Uninterruptible Power Supply (UPS) systems using Monte-Carlo simulation

2011 ◽  
Author(s):  
Mohd Khairil Rahmat ◽  
Slobodan Jovanovic ◽  
Kwok Lun Lo
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Power Supply ◽  
Uninterruptible Power Supply ◽  
Uninterruptible Power ◽  
Reliability And Availability

scholarly journals Uninterruptible Power Supply Improves Precision and External Validity of Telomere Length Measurement via qPCR

2020 ◽  
Vol 1 ◽  
Author(s):  
Waylon J. Hastings ◽  
Dan T.A. Eisenberg ◽  
Idan Shalev
Keyword(s):  
Telomere Length ◽  
Power Supply ◽  
External Validity ◽  
High Performance ◽  
Epidemiological Studies ◽  
Storage Conditions ◽  
Amplification Efficiency ◽  
Uninterruptible Power Supply ◽  
Uninterruptible Power ◽  
The Impact

Abstract Technical challenges associated with telomere length (TL) measurements have prompted concerns regarding their utility as a biomarker of aging. Several factors influence TL assessment via qPCR, the most common measurement method in epidemiological studies, including storage conditions and DNA extraction method. Here, we tested the impact of power supply during the qPCR assay. Momentary fluctuations in power can affect the functioning of high-performance electronics, including real-time thermocyclers. We investigated if mitigating these fluctuations by using an uninterruptible power supply (UPS) influenced TL assessment via qPCR. Samples run with a UPS had significantly lower standard deviation (p < 0.001) and coefficient of variation (p < 0.001) across technical replicates than those run without a UPS. UPS usage also improved exponential amplification efficiency at the replicate, sample, and plate levels. Together these improvements translated to increased performance across metrics of external validity including correlation with age, within-person correlation across tissues, and correlation between parents and offspring.

Sign in / Sign up

Export Citation Format

Share Document