An uncertainty-driven approach to vortex analysis using oracle consensus and spatial proximity

2015 ◽  
Author(s):  
Ayan Biswas ◽  
David Thompson ◽  
Wenbin He ◽  
Qi Deng ◽  
Chun-Ming Chen ◽  
...  
Keyword(s):  
Spatial Proximity

scholarly journals Altered Spatial Composition of the Immune Cell Repertoire in Association to CD34+ Blasts in Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 186
Author(s):  
Marcus Bauer ◽  
Christoforos Vaxevanis ◽  
Haifa Kathrin Al-Ali ◽  
Nadja Jaekel ◽  
Christin Le Hoa Naumann ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndromes ◽  
Myeloid Leukemia ◽  
Multispectral Imaging ◽  
Immune Cell ◽  
Genetic Alterations ◽  
Spatial Proximity ◽  
Secondary Acute Myeloid Leukemia ◽  
Acute Myeloid

Background: Myelodysplastic syndromes (MDS) are caused by a stem cell failure and often include a dysfunction of the immune system. However, the relationship between spatial immune cell distribution within the bone marrow (BM), in relation to genetic features and the course of disease has not been analyzed in detail. Methods: Histotopography of immune cell subpopulations and their spatial distribution to CD34+ hematopoietic cells was determined by multispectral imaging (MSI) in 147 BM biopsies (BMB) from patients with MDS, secondary acute myeloid leukemia (sAML), and controls. Results: In MDS and sAML samples, a high inter-tumoral immune cell heterogeneity in spatial proximity to CD34+ blasts was found that was independent of genetic alterations, but correlated to blast counts. In controls, no CD8+ and FOXP3+ T cells and only single MUM1p+ B/plasma cells were detected in an area of ≤10 μm to CD34+ HSPC. Conclusions: CD8+ and FOXP3+ T cells are regularly seen in the 10 μm area around CD34+ blasts in MDS/sAML regardless of the course of the disease but lack in the surrounding of CD34+ HSPC in control samples. In addition, the frequencies of immune cell subsets in MDS and sAML BMB differ when compared to control BMB providing novel insights in immune deregulation.

On the emergence and structure of a new regional network

2001 ◽  
Vol 20 (3) ◽  
pp. 249-256
Author(s):  
Helena Mäkinen
Keyword(s):  
Economic Development ◽  
Pharmaceutical Industry ◽  
Trade Unions ◽  
Spatial Proximity ◽  
Government Agencies ◽  
Research Institutions ◽  
Regional Network ◽  
Trade Associations ◽  
Chambers Of Commerce

This paper discusses the concept of a regional network as well as the empirical emergence of it in the Finnish pharmaceutical industry. A regional network is characterised by relatively stable relations between legally independent firms, which co-operate in spatial proximity. Financial, educational and research institutions are closely tied into these networks as are government agencies, trade associations, chambers of commerce and trade unions. The paper concludes that the new pharmaceutical industry in Finland has succeeded in building a growing regional network where actors work together in order to increase the value of the network. At the same time the network fosters industrial and economic development in the region.

scholarly journals Third-Party Effects in Stakeholder Interviews

2020 ◽  
Vol 19 ◽  
pp. 160940692096648
Author(s):  
Melissa Beresford ◽  
J. Leah Jones ◽  
Julia C. Bausch ◽  
Clinton F. Williams ◽  
Amber Wutich ◽  
...  
Keyword(s):  
Natural Resource Management ◽  
Interdisciplinary Research ◽  
Stakeholder Engagement ◽  
Third Party ◽  
Spatial Proximity ◽  
Sensitive Topics ◽  
Research Designs ◽  
Study Population ◽  
Coding Strategy ◽  
Qualitative Analyses

This paper examines the effect of having a third-party scientific expert present in stakeholder interviews. The study was conducted as part of a larger project on stakeholder engagement for natural resource management in the Verde Valley region of Arizona. We employed an experimental design, conducting stakeholder interviews both with and without an identified scientific expert present. Our sample consisted of 12 pairs of interviewees (24 total participants) who we matched based on their occupation, sex, and spatial proximity. For each pair, the scientific expert was present as a third party in one interview and absent in the other. We used a word-based coding strategy to code all interview responses for three known areas of sensitivity among the study population (risk, gatekeeping, and competence). We then performed both quantitative and qualitative analyses to compare responses across the two interview groups. We found that the presence of a scientific expert did not have a statistically significant effect on the mention of sensitive topics among stakeholders. However, our qualitative results show that the presence of a scientific expert had subtle influences on the ways that stakeholders discussed sensitive topics, particularly in placing emphasis on their own credibility and knowledge. Our findings indicate that researchers may be able to pursue collaborative, interdisciplinary research designs with multiple researchers present during interviews without concerns of strongly influencing data elicitation on sensitive topics. However, researchers should be cognizant of the subtle ways in which the presence of a third-party expert may influence the credibility claims and knowledge assertions made by respondents when a third-party expert is present during stakeholder interviews.

scholarly journals Extremely Halophilic Biohydrogen Producing Microbial Communities from High-Salinity Soil and Salt Evaporation Pond

Fuels ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 241-252
Author(s):  
Dyah Asri Handayani Taroepratjeka ◽  
Tsuyoshi Imai ◽  
Prapaipid Chairattanamanokorn ◽  
Alissara Reungsang
Keyword(s):  
Microbial Communities ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
High Salinity ◽  
Amplicon Sequencing ◽  
Spatial Proximity ◽  
Lignocellulosic Waste ◽  
Evaporation Pond ◽  
Operational Taxonomic Units ◽  
Determining Factor

Extreme halophiles offer the advantage to save on the costs of sterilization and water for biohydrogen production from lignocellulosic waste after the pretreatment process with their ability to withstand extreme salt concentrations. This study identifies the dominant hydrogen-producing genera and species among the acclimatized, extremely halotolerant microbial communities taken from two salt-damaged soil locations in Khon Kaen and one location from the salt evaporation pond in Samut Sakhon, Thailand. The microbial communities’ V3–V4 regions of 16srRNA were analyzed using high-throughput amplicon sequencing. A total of 345 operational taxonomic units were obtained and the high-throughput sequencing confirmed that Firmicutes was the dominant phyla of the three communities. Halanaerobium fermentans and Halanaerobacter lacunarum were the dominant hydrogen-producing species of the communities. Spatial proximity was not found to be a determining factor for similarities between these extremely halophilic microbial communities. Through the study of the microbial communities, strategies can be developed to increase biohydrogen molar yield.

scholarly journals Spatial Proximity of ‘Ataulfo’ to ‘Haden’ Cultivar Increases Mango Yield and Decreases Incidence of Nubbins

Agronomy ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 450
Author(s):  
Rodrigo Lucas-García ◽  
Víctor Rosas-Guerrero ◽  
Lorena Alemán-Figueroa ◽  
R. Carlos Almazán-Núñez ◽  
Juan Violante-González ◽  
...  
Keyword(s):  
Lower Incidence ◽  
International Market ◽  
Spatial Proximity ◽  
Self Incompatibility ◽  
Total Income ◽  
High Incidence ◽  
Increasing Demand ◽  
Economic Income

Mexico is the leading exporter of mangos worldwide, and ‘Ataulfo’ is one of the most popular cultivars. However, their production has dramatically dropped in recent years due to the high incidence of nubbins. One of the possible causes is the presence of a delayed self-incompatibility found in this cultivar; thus, proximity to compatible cultivars may help to reduce this incidence. Nevertheless, there is a lack of studies that have rigorously tested this hypothesis in this cultivar. For two consecutive years, the present study evaluated the incidence of nubbins, as well as the quality and quantity of commercial fruits of ‘Ataulfo’ trees located at 10, 30, and 50 m away from ‘Haden’ cultivar. Additionally, the yield and economic income of different planting designs were estimated. During both sampling periods, our results clearly indicated that at 10 m away from ‘Haden’ individuals, ‘Ataulfo’ trees presented a lower incidence of nubbins and higher production of commercial fruits, and higher yield and total income per hectare than at 30 or 50 m away from them. These results indicate that planting designs of ‘Ataulfo’ trees located 10 m away from ‘Haden’ will help to satisfy the increasing demand for mangos of this cultivar in the international market.

scholarly journals Measuring Legacies of Collective Racial Violence

2021 ◽  
Vol 694 (1) ◽  
pp. 122-139
Author(s):  
Sarah Gaby
Keyword(s):  
Racial Violence ◽  
Spatial Proximity ◽  
Empirical Inquiry ◽  
Legacy Effect ◽  
Housing Segregation ◽  
Temporal And Spatial ◽  
Racialized Violence ◽  
The Relationship

The “legacy effect” of lynchings and other forms of racialized violence has shaped patterns of inequality in America. While past studies have been relatively similar in their design—relating basic counts of lynchings to various contemporary outcomes—I argue for and demonstrate a more nuanced approach. I show that if we think of racialized violence as more than just the act of lynching, and consider both the temporal and spatial proximity between historic events of racial violence and contemporary inequality, we can establish this relationship in a more fulsome way. In the case of this study, the relationship is drawn to housing segregation. I argue that expanding the conceptualization of racial violence is critical for both empirical inquiry and shaping community efforts around redress.

scholarly journals Mobility patterns are associated with experienced income segregation in large US cities

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Esteban Moro ◽  
Dan Calacci ◽  
Xiaowen Dong ◽  
Alex Pentland
Keyword(s):  
Large Scale ◽  
Mobility Model ◽  
Coarse Grained ◽  
Spatial Proximity ◽  
Mobility Patterns ◽  
Data Set ◽  
Residential Patterns ◽  
Income Segregation ◽  
Mobility Data ◽  
Mobility Behavior

AbstractTraditional understanding of urban income segregation is largely based on static coarse-grained residential patterns. However, these do not capture the income segregation experience implied by the rich social interactions that happen in places that may relate to individual choices, opportunities, and mobility behavior. Using a large-scale high-resolution mobility data set of 4.5 million mobile phone users and 1.1 million places in 11 large American cities, we show that income segregation experienced in places and by individuals can differ greatly even within close spatial proximity. To further understand these fine-grained income segregation patterns, we introduce a Schelling extension of a well-known mobility model, and show that experienced income segregation is associated with an individual’s tendency to explore new places (place exploration) as well as places with visitors from different income groups (social exploration). Interestingly, while the latter is more strongly associated with demographic characteristics, the former is more strongly associated with mobility behavioral variables. Our results suggest that mobility behavior plays an important role in experienced income segregation of individuals. To measure this form of income segregation, urban researchers should take into account mobility behavior and not only residential patterns.

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