The axial distribution of gas hold-up and solid concentration in the slurry reactor are studied by the cold-model test, the principle of distribution is got. Furthermore, a new concept, fresh gas hold-up is put forward. As to the process of DME from synthesis gas by one-step process in the slurry reactor, according to the principle of axial distribution of gas hold-up and solid concentration in the reactor, the author put forward a novel design of the slurry, thus the space of the reactor is used fully, the reactive conversion can be raised, the productive capacity of reactor also can be raised.