Crosstalk and scatter correction in simultaneous dual isotope SPECT imaging using four energy windows method

2002 ◽  
Author(s):  
M.Y. Paek ◽  
J.S. Lee ◽  
D.S. Lee ◽  
J.-K. Chung ◽  
M.C. Lee
Keyword(s):  
Scatter Correction ◽  
Spect Imaging ◽  
Dual Isotope

Monte Carlo-based scatter correction considering the tailing effect of a CdTe detector for dual-isotope brain SPECT imaging

2016 ◽  
Vol 2 (4) ◽  
pp. 045010 ◽  
Author(s):  
Atsuro Suzuki ◽  
Wataru Takeuchi ◽  
Yuichiro Ueno ◽  
Keiji Kobashi ◽  
Takuya Toyonaga ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Scatter Correction ◽  
Brain Spect ◽  
Spect Imaging ◽  
Dual Isotope ◽  
Cdte Detector

scholarly journals Simultaneous Visualization of 161Tb- and 177Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 536
Author(s):  
Francesca Borgna ◽  
Patrick Barritt ◽  
Pascal V. Grundler ◽  
Zeynep Talip ◽  
Susan Cohrs ◽  
...  
Keyword(s):  
Pharmacokinetic Profile ◽  
Somatostatin Analogues ◽  
Distribution Coefficients ◽  
Spect Imaging ◽  
Cell Uptake ◽  
Organ Distribution ◽  
Dual Isotope ◽  
Biodistribution Studies ◽  
Simultaneous Visualization

The decay of terbium-161 results in the emission of β¯-particles as well as conversion and Auger electrons, which makes terbium-161 interesting for therapeutic purposes. The aim of this study was to use dual-isotope SPECT imaging in order to demonstrate visually that terbium-161 and lutetium-177 are interchangeable without compromising the pharmacokinetic profile of the radiopharmaceutical. The 161Tb- and 177Lu-labeled somatostatin (SST) analogues DOTATOC (agonist) and DOTA-LM3 (antagonist) were tested in vitro to demonstrate equal properties regarding distribution coefficients and cell uptake into SST receptor-positive AR42J tumor cells. The radiopeptides were further investigated in AR42J tumor-bearing nude mice using the method of dual-isotope (terbium-161/lutetium-177) SPECT/CT imaging to enable the visualization of their distribution profiles in the same animal. Equal pharmacokinetic profiles were demonstrated for either of the two peptides, irrespective of whether it was labeled with terbium-161 or lutetium-177. Moreover, the visualization of the sub-organ distribution confirmed similar behavior of 161Tb- and 177Lu-labeled SST analogues. The data were verified in quantitative biodistribution studies using either type of peptide labeled with terbium-161 or lutetium-177. While the radionuclide did not have an impact on the organ distribution, this study confirmed previous data of a considerably higher tumor uptake of radiolabeled DOTA-LM3 as compared to the radiolabeled DOTATOC.

Model-based crosstalk compensation for simultaneous Tc99m∕I123 dual-isotope brain SPECT imaging

2007 ◽  
Vol 34 (9) ◽  
pp. 3530-3543 ◽  
Author(s):  
Yong Du ◽  
Benjamin M. W. Tsui ◽  
Eric C. Frey
Keyword(s):  
Brain Spect ◽  
Spect Imaging ◽  
Dual Isotope ◽  
Model Based

scholarly journals Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection

2019 ◽  
Vol 15 ◽  
pp. 178-185
Author(s):  
Lianwen Zhang ◽  
Lukkana Suksanpaisan ◽  
Huailei Jiang ◽  
Timothy R. DeGrado ◽  
Stephen J. Russell ◽  
...  
Keyword(s):  
Virus Infection ◽  
Reporter Gene ◽  
Oncolytic Virus ◽  
Spect Imaging ◽  
Dual Isotope ◽  
Tumor Susceptibility

scholarly journals Evaluation of simultaneous 201Tl/99mTc dual-isotope cardiac SPECT imaging with model-based crosstalk compensation using canine studies

2013 ◽  
Vol 21 (2) ◽  
pp. 329-340 ◽  
Author(s):  
Y. Du ◽  
J. M. Links ◽  
L. Becker ◽  
A. F. DiPaula ◽  
T. Frank ◽  
...  
Keyword(s):  
Spect Imaging ◽  
Cardiac Spect ◽  
Dual Isotope ◽  
Model Based

scholarly journals Dual isotope thallium and indium antimyosin SPECT imaging to identify acute infarct patients at further ischemic risk.

Circulation ◽  
1990 ◽  
Vol 81 (1) ◽  
pp. 37-45 ◽  
Author(s):  
L L Johnson ◽  
D W Seldin ◽  
A M Keller ◽  
R M Wall ◽  
K Bhatia ◽  
...  
Keyword(s):  
Spect Imaging ◽  
Dual Isotope ◽  
Acute Infarct

scholarly journals Optimisation of Simultaneous Tl-201/Tc-99m Dual Isotope Reconstruction with Monte-Carlo-Based Scatter Correction

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Tuija Kangasmaa ◽  
Jyrki Kuikka ◽  
Antti Sohlberg
Keyword(s):  
Monte Carlo ◽  
Myocardial Perfusion ◽  
Scatter Correction ◽  
Reconstruction Algorithm ◽  
Myocardial Perfusion Spect ◽  
Energy Window ◽  
Dual Isotope ◽  
Expectation Maximisation ◽  
Perfusion Spect

Simultaneous Tl-201/Tc-99m dual isotope myocardial perfusion SPECT is seriously hampered by down-scatter from Tc-99m into the Tl-201 energy window. This paper presents and optimises the ordered-subsets-expectation-maximisation-(OS-EM-) based reconstruction algorithm, which corrects the down-scatter using an efficient Monte Carlo (MC) simulator. The algorithm starts by first reconstructing the Tc-99m image with attenuation, collimator response, and MC-based scatter correction. The reconstructed Tc-99m image is then used as an input for an efficient MC-based down-scatter simulation of Tc-99m photons into the Tl-201 window. This down-scatter estimate is finally used in the Tl-201 reconstruction to correct the crosstalk between the two isotopes. The mathematical 4D NCAT phantom and physical cardiac phantoms were used to optimise the number of OS-EM iterations where the scatter estimate is updated and the number of MC simulated photons. The results showed that two scatter update iterations and 105 simulated photons are enough for the Tc-99m and Tl-201 reconstructions, whereas 106 simulated photons are needed to generate good quality down-scatter estimates. With these parameters, the entire Tl-201/Tc-99m dual isotope reconstruction can be accomplished in less than 3 minutes.

scholarly journals Improved scatter correction with factor analysis for planar and SPECT imaging

2017 ◽  
Vol 88 (9) ◽  
pp. 094303 ◽  
Author(s):  
Peter Knoll ◽  
Arman Rahmim ◽  
Selma Gültekin ◽  
Martin Šámal ◽  
Michael Ljungberg ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Scatter Correction ◽  
Spect Imaging
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