scholarly journals Optogenetic activation of fiber-specific compound action potentials in the mouse vagus nerve

2019 ◽  
Author(s):  
Tea Tsaava ◽  
Adam M. Kressel ◽  
Kunihiro Uryu ◽  
Sangeeta S. Chavan ◽  
Kevin J. Tracey ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Action Potentials ◽  
Compound Action Potentials ◽  
Compound Action

scholarly journals A wrappable microwire electrode for awake, chronic interfacing with small diameter autonomic peripheral nerves

2018 ◽  
Author(s):  
Jessica D. Falcone ◽  
Tristan Liu ◽  
Laura Goldman ◽  
David D. Pogue ◽  
Malgorzata Straka ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Peripheral Nerves ◽  
Action Potentials ◽  
Small Diameter ◽  
Preclinical Model ◽  
Preclinical Models ◽  
Acute Setting ◽  
Bioelectronic Medicine ◽  
Compound Action Potentials ◽  
Compound Action

Bioelectronic medicine requires the ability to monitor and modulate nerve activity in awake patients over time. The vagus nerve is a promising stimulation target, and preclinical models often use mice. However, an awake, chronic mouse vagus nerve interface has yet to be demonstrated. Here, we developed a functional wrappable microwire electrode to chronically interface with the small diameter mouse cervical vagus nerve (∼100 μm). In an acute setting, the wrappable microwire had similar recording performance to commercially available electrodes. A chronic, awake mouse model was then developed to record spontaneous compound action potentials (CAPs). Viable signal-to-noise ratios (SNRs) were obtained from the wrappable microwires between 30 and 60 days (n = 8). Weekly impedance measurements showed no correlation between SNR or time. The wrappable microwires successfully interfaced with small diameter nerves and has been validated in a chronic, awake preclinical model, which can better facilitate clinical translation for bioelectronic medicine.

Intraoperative human vagus nerve compound action potentials

2004 ◽  
Vol 110 (4) ◽  
pp. 232-238 ◽  
Author(s):  
M. S. Evans ◽  
S. Verma-Ahuja ◽  
D. K. Naritoku ◽  
J. A. Espinosa
Keyword(s):  
Vagus Nerve ◽  
Action Potentials ◽  
Compound Action Potentials ◽  
Compound Action

Stretch of mammalian nerve in vitro: Effect on compound action potentials

2000 ◽  
Vol 5 (4) ◽  
pp. 227-235 ◽  
Author(s):  
Sidney Ochs ◽  
Rahman Pourmand ◽  
Kenan Si ◽  
Richard N. Friedman
Keyword(s):  
Action Potentials ◽  
Compound Action Potentials ◽  
Vitro Effect ◽  
Mammalian Nerve ◽  
Compound Action

scholarly journals Site of cochlear stimulation and its effect on electrically evoked compound action potentials using the MED-EL standard electrode array

2009 ◽  
Vol 8 (1) ◽  
pp. 40 ◽  
Author(s):  
Stefan Brill ◽  
Joachim Müller ◽  
Rudolf Hagen ◽  
Alexander Möltner ◽  
Steffi-Johanna Brockmeier ◽  
...  
Keyword(s):  
Action Potentials ◽  
Electrode Array ◽  
Compound Action Potentials ◽  
Compound Action

Using Evoked Compound Action Potentials to Assess Activation of Electrodes and Predict C-Levels in the Tempo+ Cochlear Implant Speech Processor

2010 ◽  
Vol 31 (1) ◽  
pp. 134-145 ◽  
Author(s):  
Isaac Alvarez ◽  
Angel de la Torre ◽  
Manuel Sainz ◽  
Cristina Roldán ◽  
Hansjoerg Schoesser ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Action Potentials ◽  
Speech Processor ◽  
Compound Action Potentials ◽  
Compound Action

Synaptic transmission in the chronically decentralized middle cervical and stellate ganglia of the dog

1983 ◽  
Vol 61 (10) ◽  
pp. 1149-1155 ◽  
Author(s):  
J. A. Armour
Keyword(s):  
Central Nervous System ◽  
Action Potentials ◽  
Autonomic Nerves ◽  
Autonomic Ganglia ◽  
Afferent Nerves ◽  
Stellate Ganglia ◽  
Compound Action Potentials ◽  
The Central Nervous System ◽  
Compound Action ◽  
Stimulation Of

Afferent stimulation of one thoracic cardiopulmonary nerve generated compound action potentials in the efferent axons of other ipsilateral cardiopulmonary nerves in dogs, 14 days after their thoracic autonomic ganglia had been decentralized. The compound action potentials were influenced by the frequency of activation and (in 5 of 12 dogs) by pharmacological autonomic blocking agents (hexamethonium, atropine, phentolamine, and propranolol). Moreover, they were abolished transiently when chymotrypsin was injected locally into the ganglia, and extendedly when manganese was injected. Thus, synapses that can be activated by stimulation of afferent nerves exist in chronically decentralized thoracic autonomic nerves and ganglia. It is proposed that regulation of the heart and lungs occurs in part via thoracic autonomic neural elements independent of the central nervous system.

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