Implantation methodology development for tissue-engineered-electronic-neural-interface (TEENI) devices

2017 ◽  
Author(s):  
Elizabeth A. Nunamaker ◽  
Benjamin S. Spearman ◽  
James B. Graham ◽  
Eric W. Atkinson ◽  
Vidhi H. Desai ◽  
...  
Keyword(s):  
Neural Interface ◽  
Methodology Development

Towards Systematization

1977 ◽  
Vol 16 (03) ◽  
pp. 125-130 ◽  
Author(s):  
P. L. Reichertz
Keyword(s):  
Clinical Medicine ◽  
Medical Science ◽  
User Involvement ◽  
Empirical Science ◽  
Target System ◽  
General Strategy ◽  
System Construction ◽  
Formal Approach ◽  
Methodology Development ◽  
Planning Development

Data processing has become an important tool in theoretical and clinical medicine. The main categories of applications are : information analysis, (bio)signal processing and the field of information logistics (information systems).The problems encountered lie in the discrepancy of the basic methods of a formal approach to an empirical science, the complexity of the target system and the system ecology, i.e. the involvement of the user and the system environment during system construction and utilization.Possible solutions to these problems are the application of system techniques, inductive planning, development of medical methodology, development of methods and techniques for user involvement and assessment of motivation and education and educational planning.The necessary general strategy in the development in medical informatics is seen in the continuing systematization of the theoretical and practical approach. It is estimated that this will eventually contribute to the systematization of medical science and practice.

scholarly journals Progress and challenges of implantable neural interfaces based on nature-derived materials

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Eugenio Redolfi Riva ◽  
Silvestro Micera
Keyword(s):  
Interface Design ◽  
Specific Area ◽  
Building Blocks ◽  
Matrix Proteins ◽  
Neural Interface ◽  
Neural Interfaces ◽  
Biomedical Science ◽  
Chronic Inflammatory Response ◽  
The Impact

AbstractNeural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-motor functions in people with disabilities, their long-term exploitation is still limited by poor biocompatibility, mechanical mismatch between the device and neural tissue and the risk of a chronic inflammatory response upon implantation.In this context, the use of nature-derived materials can help address these issues. Examples of these materials, such as extracellular matrix proteins, peptides, lipids and polysaccharides, have been employed for decades in biomedical science. Their excellent biocompatibility, biodegradability in the absence of toxic compound release, physiochemical properties that are similar to those of human tissues and reduced immunogenicity make them outstanding candidates to improve neural interface biocompatibility and long-term implantation safety. The objective of this review is to highlight progress and challenges concerning the impact of nature-derived materials on neural interface design. The use of these materials as biocompatible coatings and as building blocks of insulation materials for use in implantable neural interfaces is discussed. Moreover, future perspectives are presented to show the increasingly important uses of these materials for neural interface fabrication and their possible use for other applications in the framework of neural engineering.

Improvement of Integrity Concepts for NPP Primary Circuit Piping

2008 ◽  
Author(s):  
Alexey Arzhaev ◽  
Sergey Butorin
Keyword(s):  
Carbon Steel ◽  
General Scheme ◽  
Primary Circuit ◽  
Feed Water ◽  
Outer Diameter ◽  
Intergranular Stress Corrosion ◽  
Methodology Development ◽  
Integrity Assessment ◽  
Piping Systems ◽  
Steel Piping

Operating NPPs license extension activities in Russia produced strong demand for safety improvement of plants build according to earlier standards. Installation of additional supports as pipe whip restraints is one of requirement in acting regulatory documentation which should be followed or compensated by appropriate measures like Leak Before Break (LBB) analyses and improvement of In-Service Inspection (ISI) and Leak Detecting System (LDS). Basic document for LBB concept application to Russian NPP piping is RD 95 10547-99. Its requirements correspond to classical LBB principles used in many countries in Europe, USA and Japan. In many real cases requirements of RD 95 10547-99 could not be applied to safety important NPP piping systems due to the presence of specific features of operational degradation due to some corrosion mechanisms: for example, erosion-corrosion (E-C) for carbon steel piping and intergranular stress corrosion cracking (IGSSC) for heat affected zones of austenitic piping weldments. For special case of RBMK piping with outer diameter 325 mm (potentially susceptible to IGSCC) special Break Preclusion Concept has been developed in Russia after IAEA Extrabudgetary Program in 2000–2002. Contrary to LBB Concept demanding for all four basic principles to be completely fulfilled BP Concept accepts some principles to be fulfilled in a balanced way with demonstration of monitored degradation effectively achieved in operation. Special BP Concept is being developed now to support integrity assessment of RBMK carbon steel steam and feed water piping potentially susceptible to E-C which requires another set of measures to demonstrate principle of controlled degradation in operation then in case of austenitic steel piping. General scheme of piping integrity analyses according to LBB and BP Concepts is discussed and examples of specific approaches to achieve controlled degradation are illustrated in paper. As result of LBB and BP Concepts application it is possible to substantiate reject of additional piping whip restraints implementation on-site. Examples of similar safety methodology development in other countries have been reported at IAEA Specialists Meeting on LBB in Kiev, Ukraine in November 2006.

Decoding peripheral nerve sensory information with a spiked flexible neural interface

2018 ◽  
Author(s):  
Jiahui Wang ◽  
Xin Yuan Thow ◽  
Hao Wang ◽  
Sanghoon Lee ◽  
Kai Voges ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Sensory Information ◽  
Neural Interface

scholarly journals A Trimodal Wireless Implantable Neural Interface System-on-Chip

2020 ◽  
Vol 14 (6) ◽  
pp. 1207-1217
Author(s):  
Yaoyao Jia ◽  
Ulkuhan Guler ◽  
Yen-Pang Lai ◽  
Yan Gong ◽  
Arthur Weber ◽  
...  
Keyword(s):  
System On Chip ◽  
Neural Interface ◽  
Interface System ◽  
On Chip
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