Microelectrode arrays studies of glutamate excitatory pathway in hippocampus CA3 by offside KCl and glutamate stimulating

2017 ◽  
Author(s):  
Guihua Xiao ◽  
Yilin Song ◽  
Song Zhang ◽  
Shengwei Xu ◽  
Lili Yang ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Excitatory Pathway

scholarly journals Extracellular detection of neuronal coupling

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elmer Guzman ◽  
Zhuowei Cheng ◽  
Paul K. Hansma ◽  
Kenneth R. Tovar ◽  
Linda R. Petzold ◽  
...  
Keyword(s):  
Action Potentials ◽  
Microelectrode Arrays ◽  
Short Latency ◽  
Spike Sorting ◽  
Neuronal Connectivity ◽  
Direct Stimulation ◽  
Multiple Electrodes

AbstractWe developed a method to non-invasively detect synaptic relationships among neurons from in vitro networks. Our method uses microelectrode arrays on which neurons are cultured and from which propagation of extracellular action potentials (eAPs) in single axons are recorded at multiple electrodes. Detecting eAP propagation bypasses ambiguity introduced by spike sorting. Our methods identify short latency spiking relationships between neurons with properties expected of synaptically coupled neurons, namely they were recapitulated by direct stimulation and were sensitive to changing the number of active synaptic sites. Our methods enabled us to assemble a functional subset of neuronal connectivity in our cultures.

scholarly journals Wafer-Scale Fabrication and Assembly Method of Multichannel Microelectrode Arrays for ECoG Application

Electronics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 316
Author(s):  
Cong Wang ◽  
Yu-Chen Wei ◽  
Ho-Kun Sung ◽  
Alok Kumar ◽  
Zhong-Liang Zhou ◽  
...  
Keyword(s):  
Printed Circuit Boards ◽  
Electrochemical Impedance ◽  
Microelectrode Arrays ◽  
Absence Seizure ◽  
Curing Conditions ◽  
Wafer Scale ◽  
In Vivo Test ◽  
Assembly Method ◽  
Signal Recording

High density electrocorticography (ECoG)-based microelectrode arrays (MEAs) are fabricated to timely record the neural activities to provide the fundamental understanding in neuroscience and biomedical engineering. This paper aims to introduce a device-based concept and wafer-scale fabrication process for MEAs. Flexible and biocompatible polyimide is applied on MEAs to bear all possible stress and strain. Detailed fabrication key techniques, including surface treatment, polyimide stability measurement, evaporation process, and curing conditions, have been discussed thoroughly. Moreover, the fabricated polyimide-based MEAs are surface-mounted on well-packaged printed circuit boards (PCBs) via a slot-type connector without any additional wire bonding to make the signal recording process easier. An absence seizure was recorded during the in vivo test, which shows the availability of signal recording based on the presented MEAs. The proposed MEAs could be remained at the skull, while the connector and PCBs can be disassembled apart. Therefore, the testing sample will get less suffering. To verify the robustness of the fabricated MEAs, the impedance properties were characterized using electrochemical impedance spectroscopy. The measured results indicate an average impedance of 12.3 ± 0.675 kΩ at 1 kHz. In total, 10 groups of MEAs were sample tested, and over 90% of the total 60 channels per 1-MEAs operated efficiently.

Observed Tissue Reactions Associated with Subacute Implantation of Cortical Intraparenchymal Microelectrode Arrays

2021 ◽  
pp. 1-3
Author(s):  
Chengyuan Wu ◽  
Ashwini D. Sharan ◽  
Michael Kogan ◽  
Robert H. Rosenwasser ◽  
John Donoghue ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Tissue Reactions

scholarly journals Crosstalk in polymer microelectrode arrays

Nano Research ◽  
2021 ◽  
Author(s):  
Yi Qiang ◽  
Wen Gu ◽  
Zehua Liu ◽  
Shanchuan Liang ◽  
Jae Hyeon Ryu ◽  
...  
Keyword(s):  
Microelectrode Arrays

scholarly journals Improving reliability and reducing costs of cardiotoxicity assessments using laser-induced cell poration on microelectrode arrays

2021 ◽  
pp. 115480
Author(s):  
Giuseppina Iachetta ◽  
Nicolò Colistra ◽  
Giovanni Melle ◽  
Lieselot Deleye ◽  
Francesco Tantussi ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Reducing Costs
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