Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography

2017 ◽  
Author(s):  
Qi Liu ◽  
Siyu Chen ◽  
Brian Soetikno ◽  
Shanbao Tong ◽  
Hao F. Zhang
Keyword(s):  
Optical Coherence Tomography ◽  
Visible Light ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Laser Speckle ◽  
Laser Speckle Imaging ◽  
Cerebral Artery Occlusion ◽  
Distal Middle Cerebral Artery

scholarly journals Fenofibrate Improves Cerebral Blood Flow after Middle Cerebral Artery Occlusion in Mice

2009 ◽  
Vol 30 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Qingmin Guo ◽  
Guangming Wang ◽  
Shobu Namura
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Laser Speckle ◽  
Laser Speckle Imaging ◽  
Ischemic Brain ◽  
Cerebral Artery Occlusion

Fibrates, one group of peroxisome proliferator-activated receptor (PPAR) activators, are lipid lowering drugs. Fibrates have been shown to attenuate brain tissue injury after focal cerebral ischemia. In this study, we investigated the impact of fenofibrate on cerebral blood flow (CBF) in male wild type and PPARα-null mice. Animals were treated for 7 days with fenofibrate and subjected to 2 h of filamentous middle cerebral artery occlusion and reperfusion under isoflurane anesthesia. Cortical surface CBF was measured by laser speckle imaging. Regional CBF (rCBF) in nonischemic animals was measured by 14C-iodoantipyrine autoradiography. Fenofibrate did not affect rCBF and mean arterial blood pressure in nonischemic animals. In ischemic animals, laser speckle imaging showed delayed expansions of ischemic area, which was attenuated by fenofibrate. Fenofibrate also enhanced CBF recovery after reperfusion. However, such effects of fenofibrate on CBF in the ischemic brain were not observed in PPARα-null mice. These findings show that fenofibrate improves CBF in the ischemic hemisphere. Moreover, fenofibrate requires PPARα expression for the cerebrovascular protective effects in the ischemic brain.

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