Closed-loop deep brain stimulation based on firing-rate regulation

2013 ◽  
Author(s):  
William Pasillas-Lepine ◽  
Ihab Haidar ◽  
Antoine Chaillet ◽  
Elena Panteley
Keyword(s):  
Deep Brain Stimulation ◽  
Firing Rate ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Rate Regulation ◽  
Deep Brain

Closed-loop programming using external responses for deep brain stimulation in Parkinson's disease

2021 ◽  
Vol 84 ◽  
pp. 47-51
Author(s):  
Fuyuko Sasaki ◽  
Genko Oyama ◽  
Satoko Sekimoto ◽  
Maierdanjiang Nuermaimaiti ◽  
Hirokazu Iwamuro ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Deep Brain

scholarly journals Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Hemmings Wu ◽  
Hartwin Ghekiere ◽  
Dorien Beeckmans ◽  
Tim Tambuyzer ◽  
Kris van Kuyck ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Deep Brain Stimulation ◽  
Open Source ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Symptom Control ◽  
Theta Oscillations ◽  
Open Source Hardware ◽  
Hippocampal Theta ◽  
Deep Brain

Abstract Conventional deep brain stimulation (DBS) applies constant electrical stimulation to specific brain regions to treat neurological disorders. Closed-loop DBS with real-time feedback is gaining attention in recent years, after proved more effective than conventional DBS in terms of pathological symptom control clinically. Here we demonstrate the conceptualization and validation of a closed-loop DBS system using open-source hardware. We used hippocampal theta oscillations as system input and electrical stimulation in the mesencephalic reticular formation (mRt) as controller output. It is well documented that hippocampal theta oscillations are highly related to locomotion, while electrical stimulation in the mRt induces freezing. We used an Arduino open-source microcontroller between input and output sources. This allowed us to use hippocampal local field potentials (LFPs) to steer electrical stimulation in the mRt. Our results showed that closed-loop DBS significantly suppressed locomotion compared to no stimulation and required on average only 56% of the stimulation used in open-loop DBS to reach similar effects. The main advantages of open-source hardware include wide selection and availability, high customizability and affordability. Our open-source closed-loop DBS system is effective and warrants further research using open-source hardware for closed-loop neuromodulation.

Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond

2019 ◽  
Vol 15 (6) ◽  
pp. 343-352 ◽  
Author(s):  
Walid Bouthour ◽  
Pierre Mégevand ◽  
John Donoghue ◽  
Christian Lüscher ◽  
Niels Birbaumer ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Deep Brain

Dual threshold neural closed loop deep brain stimulation in Parkinson disease patients

2019 ◽  
Vol 12 (4) ◽  
pp. 868-876 ◽  
Author(s):  
A. Velisar ◽  
J. Syrkin-Nikolau ◽  
Z. Blumenfeld ◽  
M.H. Trager ◽  
M.F. Afzal ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Deep Brain

scholarly journals Neural closed-loop deep brain stimulation for freezing of gait

2020 ◽  
Vol 13 (5) ◽  
pp. 1320-1322 ◽  
Author(s):  
Matthew N. Petrucci ◽  
Raumin S. Neuville ◽  
M. Furqan Afzal ◽  
Anca Velisar ◽  
Chioma M. Anidi ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Freezing Of Gait ◽  
Deep Brain
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