Using optimally focused electromagnetic power for hyperthermia treatment of deep tumors in biological tissue

2003 ◽  
Author(s):  
C.M. Rappaport
Keyword(s):  
Biological Tissue ◽  
Hyperthermia Treatment ◽  
Electromagnetic Power

scholarly journals Heat Transfer Modeling in Bone Tumour Hyperthermia Induced by Hydroxyapatite Magnetic Thermo-Seeds

2020 ◽  
Vol 14 (1) ◽  
pp. 77-89
Author(s):  
Fabio Fanari ◽  
Lorena Mariani ◽  
Francesco Desogus
Keyword(s):  
Heat Transfer ◽  
Numerical Models ◽  
Bone Tumour ◽  
Heat Transfer Process ◽  
Thermal Treatments ◽  
Hyperthermia Treatment ◽  
Theoretical Frameworks ◽  
Thermal Dynamics ◽  
Electromagnetic Power ◽  
Proposed Model

Background: Hyperthermia is an adjuvant oncologic thermal therapy. In the case of deep-seated bone cancers, the interstitial hyperthermia treatment can be performed using thermo-seeds, implanted biomaterial components that are able to convert external electromagnetic power into thermal one. Several magnetic biomaterials have been synthesized for thermal treatments of cancer. However, less attention has been paid to the modeling description of the therapy, especially when the bio-heat transfer process is coupled to the electromagnetic heating. Objective: In this work, a comparison between the available analytical and numerical models is presented. Methods: A non-linear multiphysics model is used to study and describe the performance of cylindrical magnetic hydroxyapatite thermo-seeds to treat residual cancer cells of bone tumours. Results: The thermal dynamics and treatment outcome are carefully evaluated. Under the exposure of a magnetic field of 30 mT, working at 300 kHz, it was found that magnetic hydroxyapatite implants with a size of 10 mm × 10 mm could increase the temperature above 42 °C for 60 min. Conclusion: The proposed model overcomes the limitations of the available theoretical frameworks, and the results reveal the relevancy of the implant geometry to the effectiveness of the hyperthermia treatment.

scholarly journals Simulation of Hyperthermic Treatment Using the Matrix of Stripline Applicators

10.14311/1253 ◽  
2010 ◽  
Vol 50 (4) ◽  
Author(s):  
B. Vrbová ◽  
L. Víšek
Keyword(s):  
Treatment Planning ◽  
Computer Tomography ◽  
Biological Tissue ◽  
Biological Model ◽  
Hyperthermia Treatment ◽  
Computer Tomography Scan ◽  
Hyperthermic Treatment ◽  
The Matrix ◽  
Tomography Scan

This paper describes the design of a microwave stripline applicator for hyperthermic treatment, and the design of an anatomically based biological model, which is a necessary part of hyperthermia treatment planning for measuring the distribution of SAR. In this paper we compare the SAR distribution in a cylindrical homogeneous agar phantom (which has similar characteristics to biological tissue) and in an anatomically based biological model of the femur (which has been developed from a computer tomography scan) using a matrix of two applicators of the same type.

Advances in Microprobe Analysis Applied to Muscle, Nerve and Gland

1982 ◽  
Vol 40 ◽  
pp. 404-407
Author(s):  
T. E. Hutchinson ◽  
D. E. Johnson ◽  
A. C. Lee ◽  
E. Y. Wang
Keyword(s):  
Biological Tissue ◽  
Microprobe Analysis ◽  
Physiological State ◽  
External Environment ◽  
Physiological Relevance ◽  
Muscle Nerve ◽  
Technique Development

Microprobe analysis of biological tissue is now in the end phase of transition from instrumental and technique development to applications pertinent to questions of physiological relevance. The promise,implicit in early investigative efforts, is being fulfilled to an extent much greater than many had predicted. It would thus seem appropriate to briefly report studies exemplifying this, ∿. In general, the distributions of ions in tissue in a preselected physiological state produced by variations in the external environment is of importance in elucidating the mechanisms of exchange and regulation of these ions.

Complementary Z-Contrast Imaging and Digital Image Processing

1985 ◽  
Vol 43 ◽  
pp. 304-305
Author(s):  
K. N. Colonna ◽  
G. Oliphant
Keyword(s):  
Image Processing ◽  
Heavy Metal ◽  
Digital Image Processing ◽  
Digital Image ◽  
Biological Tissue ◽  
Biological Imaging ◽  
Tissue Preparation ◽  
Contrast Imaging ◽  
Imaging Tool ◽  
Z Contrast

Harmonious use of Z-contrast imaging and digital image processing as an analytical imaging tool was developed and demonstrated in studying the elemental constitution of human and maturing rabbit spermatozoa. Due to its analog origin (Fig. 1), the Z-contrast image offers information unique to the science of biological imaging. Despite the information and distinct advantages it offers, the potential of Z-contrast imaging is extremely limited without the application of techniques of digital image processing. For the first time in biological imaging, this study demonstrates the tremendous potential involved in the complementary use of Z-contrast imaging and digital image processing.Imaging in the Z-contrast mode is powerful for three distinct reasons, the first of which involves tissue preparation. It affords biologists the opportunity to visualize biological tissue without the use of heavy metal fixatives and stains. For years biologists have used heavy metal components to compensate for the limited electron scattering properties of biological tissue.

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