Hand-Off Evolution with Multiple Interfaces

2008 ◽  
Vol 10 (5) ◽  
pp. 22-28 ◽  
Author(s):  
Ching-Lun Lin ◽  
Chih-Hsiang Ho ◽  
Jen-Yi Pan
Keyword(s):  
Multiple Interfaces ◽  
Hand Off

Don't Let E-Records Lead to Common Hand-Off Mistakes

2012 ◽  
Vol 5 (5) ◽  
pp. 17
Author(s):  
MARY ELLEN SCHNEIDER
Keyword(s):  
Hand Off

scholarly journals Cryo-EM structure of human Wntless in complex with Wnt3a

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Qing Zhong ◽  
Yanyu Zhao ◽  
Fangfei Ye ◽  
Zaiyu Xiao ◽  
Gaoxingyu Huang ◽  
...  
Keyword(s):  
Transmembrane Domain ◽  
Transmembrane Protein ◽  
Multiple Interfaces ◽  
Wnt Proteins ◽  
Binding Partners ◽  
Multiple Binding Sites ◽  
Evolutionarily Conserved ◽  
Multiple Binding ◽  
Hydrophobic Tunnel ◽  
Conserved Core

AbstractWntless (WLS), an evolutionarily conserved multi-pass transmembrane protein, is essential for secretion of Wnt proteins. Wnt-triggered signaling pathways control many crucial life events, whereas aberrant Wnt signaling is tightly associated with many human diseases including cancers. Here, we report the cryo-EM structure of human WLS in complex with Wnt3a, the most widely studied Wnt, at 2.2 Å resolution. The transmembrane domain of WLS bears a GPCR fold, with a conserved core cavity and a lateral opening. Wnt3a interacts with WLS at multiple interfaces, with the lipid moiety on Wnt3a traversing a hydrophobic tunnel of WLS transmembrane domain and inserting into membrane. A β-hairpin of Wnt3a containing the conserved palmitoleoylation site interacts with WLS extensively, which is crucial for WLS-mediated Wnt secretion. The flexibility of the Wnt3a loop/hairpin regions involved in the multiple binding sites indicates induced fit might happen when Wnts are bound to different binding partners. Our findings provide important insights into the molecular mechanism of Wnt palmitoleoylation, secretion and signaling.

scholarly journals Using a Warm Hand-Off Approach to Enroll African American Caregivers in a Multi-Site Clinical Trial: The Handshake Protocol

2021 ◽  
pp. 073346482199292
Author(s):  
Fayron Epps ◽  
Glenna Brewster ◽  
Judy S. Phillips ◽  
Rachel Nash ◽  
Raj C. Shah ◽  
...  
Keyword(s):  
African American ◽  
Controlled Trial ◽  
Culturally Congruent ◽  
Phone Calls ◽  
Emory University ◽  
Hand Off ◽  
Site Coordinator ◽  
Handshake Protocol ◽  
Minority Participants ◽  
African American Caregivers

“Testing Tele-Savvy” was a three-arm randomized controlled trial that recruited participants from four National Institute on Aging (NIA)–funded Alzheimer’s Disease Centers with Emory University serving as the coordinating center. The enrollment process involved each center providing a list of eligible caregivers to the coordinating center to consent. Initially, the site proposed to recruit primarily African American caregivers generated a significant amount of referrals to the coordinating center, but a gap occurred in translating them into enrolled participants. To increase the enrollment rate, a “Handshake Protocol” was established, which included a warm handoff approach. During preset phone calls each week, the research site coordinator introduced potential participants to a culturally congruent co-investigator from the coordinating center who then completed the consent process. Within the first month of implementation, the team was 97% effective in meeting its goals. This protocol is an example of a successful, innovative approach to enrolling minority participants in multi-site clinical trials.

scholarly journals Interns Overestimate the Effectiveness of Their Hand-off Communication

PEDIATRICS ◽  
2010 ◽  
Vol 125 (3) ◽  
pp. 491-496 ◽  
Author(s):  
V. Y. Chang ◽  
V. M. Arora ◽  
S. Lev-Ari ◽  
M. D'Arcy ◽  
B. Keysar
Keyword(s):  
Hand Off

Streptomyces IHF uses multiple interfaces to bind DNA

2019 ◽  
Vol 1863 (11) ◽  
pp. 129405 ◽  
Author(s):  
Tamiza Nanji ◽  
Emma J. Gehrke ◽  
Yao Shen ◽  
Melanie Gloyd ◽  
Xiafei Zhang ◽  
...  
Keyword(s):  
Multiple Interfaces

scholarly journals Watching Neurons Hand Off Molecules

2002 ◽  
Vol 10 (1) ◽  
pp. 3-34
Author(s):  
Stephen W. Carmichael
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Target Cells ◽  
Nerve Growth ◽  
Hand Off ◽  
Presynaptic Neurons

Since the discovery of nerve growth factor, it has been thought that neurotrophic factors are released or secreted from target cells. However, more recently it has been suggested that a specific neurotrophic factor known as brain-derived neurotrophic factor (BDNF) may reach target cells directly from pre-synaptic axons. It has not been known how these molecules get from the neuron in which they are produced to the target cells. Keigo Kohara, Akihiko Kitamura, Mieko Morishima, and Tadaharu Tsumoto have demonstrated that BDNF is transported anterogradely from presynaptic neurons to target neurons.

Hand Off Issues in 3G UMTS Networks

2007 ◽  
Author(s):  
Tauseef Mubeen ◽  
Imran Ali Tasadduq ◽  
Junaid Ahmed Zubairi
Keyword(s):  
Hand Off ◽  
Umts Networks
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