NGBT: Next-Generation Broadcast Television: Continued Rapid Technical Advances

2012 ◽  
Vol 1 (2) ◽  
pp. 32-35 ◽  
Author(s):  
Wayne Luplow
2012 ◽  
Vol 121 (5) ◽  
pp. 47-63 ◽  
Author(s):  
Luke Fay ◽  
James Kutzner ◽  
Skip Pizzi ◽  
Jerry Whitaker ◽  
Yiyan Wu ◽  
...  

2016 ◽  
Vol 33 (1) ◽  
pp. 158-162 ◽  
Author(s):  
Richard Chernock ◽  
Jerry C. Whittaker

2020 ◽  
Vol 13 (7) ◽  
pp. 1933-1970 ◽  
Author(s):  
Jingwen Zhou ◽  
Jianli Cheng ◽  
Bin Wang ◽  
Huisheng Peng ◽  
Jun Lu

An overview of the recent technical advances and major dilemmas facing currently available flexible metal–gas batteries for use in wearable electronics is presented.


2018 ◽  
Vol 24 (22) ◽  
pp. 2530-2540 ◽  
Author(s):  
Jian Han ◽  
Yonghong Xia ◽  
Lejun Lin ◽  
Zuoguang Zhang ◽  
Hui Tian ◽  
...  

Depression is a highly prevalent disorder that affects more than 300 million adults worldwide in 2015. Depression also frequently coexists with many other conditions such as osteoporosis and one-third of the Intensive Care Unit (ICU) survivors had depressive symptoms. Antidepressants have become the most commonly prescribed drugs in the United States. In addition to the regular process, drug discovery and development (R&D) for depression presents extra challenges because of the heterogeneity of the symptoms and various co-occurring disorders. Botanical medicine with multi-functional nature has been proposed to be more effective, providing rapid control of core and comorbid conditions of depression. With the technical advances in analytical instruments, metabolomics is entering into a “new generation”. Next-generation metabolomics (NGM) has the capability to comprehensively characterize drug-induced metabolic changes in the biological systems. NGM has demonstrated great potential in all the stages of pharmaceutical R&D in the last 10 years. Albiflorin isolated from Peony roots is a promising drug candidate with multi-target for depression and is currently under development by Beijing Wonner Biotech. In this work, we summarized the common analytical platforms for NGM and its main applications in drug R&D. We used albiflorin as an example to illustrate how NGM improves our understanding of drug candidate actions and facilitates drug safety evaluation. Future directions on how to expand the use of NGM for new antidepressant development in pharmaceutical industry were also discussed.


2014 ◽  
Vol 60 (2) ◽  
pp. 185-192 ◽  
Author(s):  
G. Kent Walker ◽  
Jun Wang ◽  
Charles Lo ◽  
Xiaoxia Zhang ◽  
Gang Bao

2004 ◽  
Vol 23 (2) ◽  
pp. 175-207 ◽  
Author(s):  
Aitor Anduaga

The creation and development of the Servicio Sismológico Español (1906-1930) clearly illustrates the complexity of the organisation of seismological networks in Spain during the Restauración and the reign of Alfonso XIII. A unique combination of technical advances, seismological knowledge and the need for safety and seismic prediction gave rise to the emergence of both state and private observatories, an important aspect of the process of scientific modernisation after the Spanish-American war of 1898. This paper aims to show how the engineer Eduardo Mier y Miura (1858-1917) played a key role in the foundation of the Servicio, despite the fact that some of his decisions and contributions were highly criticised by the next generation of seismologists. Figures such as Vicente Inglada, José Galbis, and Alfonso Rey Pastor carried out a complete reorganisation of the Servicio. These events did not stem from the well-known regeneracionismo movement which took place at the turn of the century, but were rather the result of internal dynamics.


Author(s):  
R. Y. Tsien ◽  
A. Minta ◽  
M. Poenie ◽  
J.P.Y. Kao ◽  
A. Harootunian

Recent technical advances now enable the continuous imaging of important ionic signals inside individual living cells with micron spatial resolution and subsecond time resolution. This methodology relies on the molecular engineering of indicator dyes whose fluorescence is strong and highly sensitive to ions such as Ca2+, H+, or Na+, or Mg2+. The Ca2+ indicators, exemplified by fura-2 and indo-1, derive their high affinity (Kd near 200 nM) and selectivity for Ca2+ to a versatile tetracarboxylate binding site3 modeled on and isosteric with the well known chelator EGTA. The most commonly used pH indicators are fluorescein dyes (such as BCECF) modified to adjust their pKa's and improve their retention inside cells. Na+ indicators are crown ethers with cavity sizes chosen to select Na+ over K+: Mg2+ indicators use tricarboxylate binding sites truncated from those of the Ca2+ chelators, resulting in a more compact arrangement of carboxylates to suit the smaller ion.


2004 ◽  
Vol 171 (4S) ◽  
pp. 389-389
Author(s):  
Manoj Monga ◽  
Ramakrishna Venkatesh ◽  
Sara Best ◽  
Caroline D. Ames ◽  
Courtney Lee ◽  
...  

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