Human exposure to microwaves and radiofrequency electromagnetic fields

1981 ◽  
Vol 23 (6) ◽  
pp. 23-24
Keyword(s):  
Electromagnetic Fields ◽  
Human Exposure ◽  
Radiofrequency Electromagnetic Fields

Amplitude-modulated radiofrequency electromagnetic fields target hepatocellular carcinoma stem cells through activation of Cav 3.2 T-type calcium channels.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 332-332
Author(s):  
Hugo Jimenez ◽  
Minghui Wang ◽  
Jacquelyn W. Zimmerman ◽  
Michael J. Pennison ◽  
Sambad Sharma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Calcium Channels ◽  
Electromagnetic Fields ◽  
Human Exposure ◽  
Whole Body ◽  
Advanced Hepatocellular Carcinoma ◽  
Advanced Hcc ◽  
Radiofrequency Electromagnetic Fields ◽  
Hcc Cells

332 Background: Amplitude-modulated 27.12 MHz radiofrequency electromagnetic fields (AM RF EMF) delivered via a spoon-shaped antenna placed on the patient’s tongue result in shrinkage of the primary and metastatic tumors in patients with advanced hepatocellular carcinoma (HCC). (Costa FP, et al. Br J Cancer. 2011;105:640-648.) The mechanism by which AM RF EMF have direct antiproliferative effect and disruption of the mitotic spindle on cancer cells is largely unknown. (Zimmerman JW, et al. Br J Cancer. 2012;106:307-313.) Methods: We assessed the Specific Absorption Rate (SAR) level and distribution inside the human body. In vitro experiments with HCC cells were performed as previously described (Zimmerman). Immunodeficient mice were subcutaneously implanted with Huh-7 HCC cells or patient-derived xenografts (PDX). Mice were exposed to HCC-specific AM RF EMF using systems replicating human exposure levels and treatment duration. Tumor samples were examined for EMT and cell cycle markers. Results: Intrabuccal delivery results in whole-body absorption of AM RF EMF. Proliferation of hepatitis B positive and negative cell lines as well as HCC cancer stem cells (CSCs) are blocked by AM RF EMF through Cav 3.2 T-type voltage gated calcium channels (VGCC). Proliferation of HCC is inhibited in vivo and tumor shrinkage occurs by dedifferentiation of HCC cells into quiescent myofibroblasts while the growth of intestinal and blood marrow cells is unaltered. Conclusions: Whole-body SAR ranges from 0.2 to 1 mW/kg and is significantly below the international safety limits for human exposure. Intrabucally-administered AM RF EMF is a novel targeted therapy for systemic treatment of advanced HCC with minimal off target effects. Inhibition of HCC CSCs may explain the extremely long term survival (>5 years) of several patients with advanced HCC.

Developing GIS portal to ensure sanitary and epidemiological surveillance of transferring radio engineering objects

2020 ◽  
Vol 99 (4) ◽  
pp. 344-350
Author(s):  
Evgeny V. Zibarev ◽  
A. S. Afanasev ◽  
O. V. Slusareva ◽  
T. I. Muragimov ◽  
V. A. Stepanets ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Analytical Data ◽  
Base Stations ◽  
Epidemiological Surveillance ◽  
Graphical Form ◽  
Residential Areas ◽  
Information Portal ◽  
Radiofrequency Electromagnetic Fields ◽  
Online Mode ◽  
Automated Processes

In recent years, in the Russian Federation there has been an increase in the levels of radiofrequency electromagnetic fields in residential areas, including due to an increase in the number of base stations (BS). The purpose of sanitary and epidemiological surveillance at the stages of placement and commissioning of base stations (BS) is to prevent their adverse effects on public health. The increase in the number of base stations, together with the advent of new electronic equipment and antennas, provide opportunities for improving the processes of their accounting at the stage of placement and monitoring of the levels of radiofrequency electromagnetic fields at the operation stage. This automation tool can be a geo-information portal for providing sanitary and epidemiological surveillance of cellular base stations. The prototype of the geo-information portal allows both calculating the size of sanitary protection zones (SPZ) and building restriction zones (RZ) from the BS in online mode, displaying the results of calculations in graphical form and issuing sanitary and epidemiological conclusions for the placement and operation of base stations. The geo-information portal has the ability to synchronize with the data of the radio frequency center. Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing will be able to receive up-to-date analytical data. There will be completely automated processes of collecting, processing and storing information on BS.

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