The combinatorial structure of linear deterministic interference channels

2012 ◽  
Author(s):  
Suvarup Saha ◽  
Randall A. Berry
Keyword(s):  
Combinatorial Structure ◽  
Interference Channels

Combinatorial Design of Molecule using Activity-Linked Substructural Topological Information as Applied to Antitubercular Compounds

2018 ◽  
Vol 15 (1) ◽  
pp. 67-81 ◽  
Author(s):  
Chandan Raychaudhury ◽  
Md. Imbesat Hassan Rizvi ◽  
Debnath Pal
Keyword(s):  
Biological Activities ◽  
Combinatorial Design ◽  
Combinatorial Structure ◽  
Potential Drug ◽  
Structure Generation ◽  
Topological Information ◽  
Active Compounds ◽  
Antitubercular Drugs ◽  
Topological Distance ◽  
Drug Molecules

Background: Generating a large number of compounds using combinatorial methods increases the possibility of finding novel bioactive compounds. Although some combinatorial structure generation algorithms are available, any method for generating structures from activity-linked substructural topological information is not yet reported. Objective: To develop a method using graph-theoretical techniques for generating structures of antitubercular compounds combinatorially from activity-linked substructural topological information, predict activity and prioritize and screen potential drug candidates. </P><P> Methods: Activity related vertices are identified from datasets composed of both active and inactive or, differently active compounds and structures are generated combinatorially using the topological distance distribution associated with those vertices. Biological activities are predicted using topological distance based vertex indices and a rule based method. Generated structures are prioritized using a newly defined Molecular Priority Score (MPS). Results: Studies considering a series of Acid Alkyl Ester (AAE) compounds and three known antitubercular drugs show that active compounds can be generated from substructural information of other active compounds for all these classes of compounds. Activity predictions show high level of success rate and a number of highly active AAE compounds produced high MPS score indicating that MPS score may help prioritize and screen potential drug molecules. A possible relation of this work with scaffold hopping and inverse Quantitative Structure-Activity Relationship (iQSAR) problem has also been discussed. The proposed method seems to hold promise for discovering novel therapeutic candidates for combating Tuberculosis and may be useful for discovering novel drug molecules for the treatment of other diseases as well.

scholarly journals Spatial DCT-Based Channel Estimation in Multi-Antenna Multi-Cell Interference Channels

2015 ◽  
Vol 63 (6) ◽  
pp. 1404-1418 ◽  
Author(s):  
Maha Alodeh ◽  
Symeon Chatzinotas ◽  
Bjorn Ottersten
Keyword(s):  
Channel Estimation ◽  
Interference Channels

Artificial intelligence techniques for rate maximization in interference channels

2021 ◽  
pp. 101294
Author(s):  
Zain Ali ◽  
Wasay Farooq ◽  
Wali Ullah Khan ◽  
Mahmood Qureshi ◽  
Guftaar Ahmad Sardar Sidhu
Keyword(s):  
Artificial Intelligence ◽  
Interference Channels ◽  
Artificial Intelligence Techniques ◽  
Rate Maximization
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