Experiences from Applying WCET Analysis in Industrial Settings

2007 ◽  
Author(s):  
Jan Gustafsson ◽  
Andreas Ermedahl
Keyword(s):  
Wcet Analysis ◽  
Industrial Settings

Spindle-Inhibiting Effects of Organotin Compounds: Effects of Trimethyltin on Chromosome Length

1990 ◽  
Vol 17 (3) ◽  
pp. 195-198
Author(s):  
Klaus Gjervig Jensen ◽  
Ole Andersen ◽  
Mogens Rønne
Keyword(s):  
Exposure Time ◽  
Industrial Applications ◽  
Chromosome Length ◽  
Peripheral Lymphocyte ◽  
Organotin Compounds ◽  
Lymphocyte Cultures ◽  
Trimethyltin Chloride ◽  
Industrial Settings ◽  
Spindle Function ◽  
Human Peripheral Lymphocyte

Organotin compounds have a number of industrial applications, and human exposures occur in various industrial settings. The present study reports effects of trimethyltin chloride (TMT) on chromosome length in asynchronous human peripheral lymphocyte cultures. The results demonstrate dose-related and exposure time-related reductions in average chromosome length. Induction of supercontraction indicates that TMT is a powerful inhibitor of spindle function. TMT would thus be expected to be able to induce aneuploidy due to non-disjunction. This study indicates the need for more-direct investigations on the spindle-inhibiting effects of TMT and other organotin compounds.

Products Liability Law – Lessons from the Military and Industrial Contexts

2020 ◽  
Vol 13 (2) ◽  
pp. 303-322
Author(s):  
Nathan A. Schachtman
Keyword(s):  
Common Law ◽  
Consumer Products ◽  
State Court ◽  
Court Cases ◽  
Industrial Products ◽  
Products Liability ◽  
Product Use ◽  
Liability Law ◽  
Industrial Settings ◽  
The Military

AbstractThe policy bases for American products liability law have developed largely through a series of state court cases that involved products sold to ordinary consumers. These cases featured significant disparities between manufacturers and injured consumers in understanding latent risks from product use, and in their ability to avoid the risks and to absorb and to distribute the costs of the risks. The policy bases that appear cogent for consumer products fail to explain or justify the imposition of liability in many industrial settings, which involve military or industrial customers that are well aware of the products’ latent risks and that have moral, common law, statutory, and regulatory duties to ensure that the industrial products are used safely.

scholarly journals Integrating continuous flow synthesis with in-line analysis and data generation

2018 ◽  
Vol 16 (33) ◽  
pp. 5946-5954 ◽  
Author(s):  
Marcus Baumann
Keyword(s):  
Continuous Flow ◽  
Fine Chemicals ◽  
Data Generation ◽  
Flow Synthesis ◽  
Niche Area ◽  
Industrial Settings ◽  
Line Analysis

Continuous flow synthesis of fine chemicals has successfully advanced from an academic niche area to a rapidly growing field of its own that directly impacts developments and applications in industrial settings.

scholarly journals Programming Native CRISPR Arrays for the Generation of Targeted Immunity

mBio ◽  
2016 ◽  
Vol 7 (3) ◽  
Author(s):  
Alexander P. Hynes ◽  
Simon J. Labrie ◽  
Sylvain Moineau
Keyword(s):  
Immune System ◽  
Nucleic Acid ◽  
Genome Editing ◽  
Dna Sequence ◽  
Adaptive Immune System ◽  
Natural Process ◽  
The Public ◽  
Adaptive Immune ◽  
Public Consciousness ◽  
Industrial Settings

ABSTRACT The adaptive immune system of prokaryotes, called CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated genes), results in specific cleavage of invading nucleic acid sequences recognized by the cell’s “memory” of past encounters. Here, we exploited the properties of native CRISPR-Cas systems to program the natural “memorization” process, efficiently generating immunity not only to a bacteriophage or plasmid but to any specifically chosen DNA sequence. IMPORTANCE CRISPR-Cas systems have entered the public consciousness as genome editing tools due to their readily programmable nature. In industrial settings, natural CRISPR-Cas immunity is already exploited to generate strains resistant to potentially disruptive viruses. However, the natural process by which bacteria acquire new target specificities (adaptation) is difficult to study and manipulate. The target against which immunity is conferred is selected stochastically. By biasing the immunization process, we offer a means to generate customized immunity, as well as provide a new tool to study adaptation.

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