scholarly journals Computational analysis of the effect of superparamagnetic nanoparticle properties on bioheat transfer in magnetic nanoparticle hyperthermia

2016 ◽  
Author(s):  
Frederik Soetaert ◽  
Luc Dupre ◽  
Guillaume Crevecoeur
Keyword(s):  
Magnetic Nanoparticle ◽  
Computational Analysis ◽  
Bioheat Transfer ◽  
Magnetic Nanoparticle Hyperthermia

Magnetic Nanoparticle Hyperthermia for Cancer Treatment: a Review On Nanoparticle Types and Thermal Analyses

2021 ◽  
Author(s):  
Kassianne J Tofani ◽  
Saeed Tiari
Keyword(s):  
Temperature Distribution ◽  
Cancer Treatment ◽  
Magnetic Nanoparticle ◽  
Thermal Analyses ◽  
Blood Perfusion ◽  
Bioheat Transfer ◽  
Manganese Zinc ◽  
Different Types ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Future Work

Abstract Magnetic nanoparticle hyperthermia (MNH) is a localized cancer treatment which uses an alternating magnetic field to excite magnetic nanoparticles (MNPs) injected into a tumor, causing them to generate heat. Once the temperature of the tumor tissue reaches about 43°C, the cancerous cells die. Different types of MNPs have been studied, including iron oxides with various coatings, Cu-Ni alloys and complex manganese/zinc particles. This paper reviews different types of MNPs and assesses them by magnetization, SAR, and Curie Temperature. We reviewed the achievements and limitations of the works in this field. A major issue with MNH is maintaining effective hyperthermia while preserving healthy tissue. Numerical modeling can predict temperature distribution and safely simulate hyperthermia. The most used bioheat transfer equation is Pennes' equation which includes a term for blood perfusion, an important factor for temperature distribution. While some models safely neglect it, most include blood perfusion term. Some recent models have also included large blood vessels, others used their own heat transfer models. This article reviews the different models and classifies them based on how they address blood flow. A need for studies with realistic tumor shapes was identified. The irregular shape of most tumors could result in less uniform temperature distribution than in the commonly used circular or spherical models. This article aims to identify potential future work to create more realistic tumor models.

scholarly journals Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5545 ◽  
Author(s):  
Izaz Raouf ◽  
Piotr Gas ◽  
Heung Soo Kim
Keyword(s):  
Numerical Model ◽  
Cancer Therapy ◽  
Magnetic Nanoparticle ◽  
Research Work ◽  
Thermal Response ◽  
Linear Response Theory ◽  
Novel Approach ◽  
Magnetic Nanoparticle Hyperthermia

Recently, in-vitro studies of magnetic nanoparticle (MNP) hyperthermia have attracted significant attention because of the severity of this cancer therapy for in-vivo culture. Accurate temperature evaluation is one of the key challenges of MNP hyperthermia. Hence, numerical studies play a crucial role in evaluating the thermal behavior of ferrofluids. As a result, the optimum therapeutic conditions can be achieved. The presented research work aims to develop a comprehensive numerical model that directly correlates the MNP hyperthermia parameters to the thermal response of the in-vitro model using optimization through linear response theory (LRT). For that purpose, the ferrofluid solution is evaluated based on various parameters, and the temperature distribution of the system is estimated in space and time. Consequently, the optimum conditions for the ferrofluid preparation are estimated based on experimental and mathematical findings. The reliability of the presented model is evaluated via the correlation analysis between magnetic and calorimetric methods for the specific loss power (SLP) and intrinsic loss power (ILP) calculations. Besides, the presented numerical model is verified with our experimental setup. In summary, the proposed model offers a novel approach to investigate the thermal diffusion of a non-adiabatic ferrofluid sample intended for MNP hyperthermia in cancer treatment.

A Numerical Approach to the Magnetic Nanoparticle Hyperthermia

2021 ◽  
Author(s):  
Alireza Ashofteh Yazdi ◽  
Antonio Callejas Zafra ◽  
Pablo Moreno ◽  
Rafa Munoz ◽  
Juan Melchor
Keyword(s):  
Magnetic Nanoparticle ◽  
Numerical Approach ◽  
Magnetic Nanoparticle Hyperthermia

scholarly journals A review on numerical modeling for magnetic nanoparticle hyperthermia: Progress and challenges

2020 ◽  
Vol 91 ◽  
pp. 102644 ◽  
Author(s):  
Izaz Raouf ◽  
Salman Khalid ◽  
Asif Khan ◽  
Jaehun Lee ◽  
Heung Soo Kim ◽  
...  
Keyword(s):  
Numerical Modeling ◽  
Magnetic Nanoparticle ◽  
Magnetic Nanoparticle Hyperthermia
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