Functional Connectivity Analysis from Multi Spike Trains on Prefrontal Cortex of Rat during Working Memory Task

2012 ◽  
Author(s):  
Dexuan Qi ◽  
Zhenguo Xiao ◽  
Xin Tian
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Memory Task ◽  
Spike Trains ◽  
Connectivity Analysis ◽  
Functional Connectivity Analysis

scholarly journals Organization of cortico-cortical pathways supporting memory retrieval across subregions of the left ventrolateral prefrontal cortex

2016 ◽  
Vol 116 (3) ◽  
pp. 920-937 ◽  
Author(s):  
Jennifer Barredo ◽  
Timothy D. Verstynen ◽  
David Badre
Keyword(s):  
Prefrontal Cortex ◽  
White Matter ◽  
Functional Connectivity ◽  
Memory Retrieval ◽  
Temporal Cortex ◽  
Functional Network ◽  
High Angular Resolution ◽  
Connectivity Analysis ◽  
Ventrolateral Prefrontal Cortex ◽  
Functional Connectivity Analysis

Functional magnetic resonance imaging (fMRI) evidence indicates that different subregions of ventrolateral prefrontal cortex (VLPFC) participate in distinct cortical networks. These networks have been shown to support separable cognitive functions: anterior VLPFC [inferior frontal gyrus (IFG) pars orbitalis] functionally correlates with a ventral fronto-temporal network associated with top-down influences on memory retrieval, while mid-VLPFC (IFG pars triangularis) functionally correlates with a dorsal fronto-parietal network associated with postretrieval control processes. However, it is not known to what extent subregional differences in network affiliation and function are driven by differences in the organization of underlying white matter pathways. We used high-angular-resolution diffusion spectrum imaging and functional connectivity analysis in unanesthetized humans to address whether the organization of white matter connectivity differs between subregions of VLPFC. Our results demonstrate a ventral-dorsal division within IFG. Ventral IFG as a whole connects broadly to lateral temporal cortex. Although several different individual white matter tracts form connections between ventral IFG and lateral temporal cortex, functional connectivity analysis of fMRI data indicates that these are part of the same ventral functional network. By contrast, across subdivisions, dorsal IFG was connected with the midfrontal gyrus and correlated as a separate dorsal functional network. These qualitative differences in white matter organization within larger macroanatomical subregions of VLPFC support prior functional distinctions among these regions observed in task-based and functional connectivity fMRI studies. These results are consistent with the proposal that anatomical connectivity is a crucial determinant of systems-level functional organization of frontal cortex and the brain in general.

A regulation role of the prefrontal cortex in the fist-edge-palm task: Evidence from functional connectivity analysis

NeuroImage ◽  
2008 ◽  
Vol 41 (4) ◽  
pp. 1345-1351 ◽  
Author(s):  
Hengyi Rao ◽  
Xin Di ◽  
Raymond C.K. Chan ◽  
Yulong Ding ◽  
Binbin Ye ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Connectivity Analysis ◽  
Functional Connectivity Analysis

scholarly journals Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3513
Author(s):  
Jaylyn Waddell ◽  
Elizabeth Hill ◽  
Shiyu Tang ◽  
Li Jiang ◽  
Su Xu ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Cognitive Flexibility ◽  
Young Adulthood ◽  
Memory Task ◽  
Ethanol Exposure ◽  
Low Doses ◽  
Prenatal Ethanol Exposure ◽  
Attentional Set

Fetal alcohol spectrum disorder (FASD) is the leading known cause of intellectual disability, and may manifest as deficits in cognitive function, including working memory. Working memory capacity and accuracy increases during adolescence when neurons in the prefrontal cortex undergo refinement. Rats exposed to low doses of ethanol prenatally show deficits in working memory during adolescence, and in cognitive flexibility in young adulthood. The cholinergic system plays a crucial role in learning and memory processes. Here we report that the combination of choline and training on a working memory task during adolescence significantly improved cognitive flexibility (performance on an attentional set shifting task) in young adulthood: 92% of all females and 81% of control males formed an attentional set, but only 36% of ethanol-exposed males did. Resting state functional magnetic resonance imaging showed that functional connectivity among brain regions was different between the sexes, and was altered by prenatal ethanol exposure and by choline + training. Connectivity, particularly between prefrontal cortex and striatum, was also different in males that formed a set compared with those that did not. Together, these findings indicate that prenatal exposure to low doses of ethanol has persistent effects on brain functional connectivity and behavior, that these effects are sex-dependent, and that an adolescent intervention could mitigate some of the effects of prenatal ethanol exposure.

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