Research on Architecture of Collaborative Agreement Signing System

2011 ◽  
Author(s):  
Ning Qiu ◽  
Hexin Lv ◽  
Guoyong Dai
Keyword(s):  
Collaborative Agreement

Randomized comparison of cyclophosphamide, imidazole carboxamide, and adriamycin versus cyclophosphamide and adriamycin in patients with advanced stage malignant mesothelioma: a Sarcoma Intergroup Study.

1987 ◽  
Vol 5 (1) ◽  
pp. 86-91 ◽  
Author(s):  
M K Samson ◽  
L P Wasser ◽  
E C Borden ◽  
H J Wanebo ◽  
R H Creech ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Drug Combination ◽  
Performance Status ◽  
Eastern Cooperative Oncology Group ◽  
Response Duration ◽  
Advanced Stage ◽  
Oncology Group ◽  
Significant Difference ◽  
Impact On Survival ◽  
Collaborative Agreement

In 1980, a consensus chemotherapy intergroup study for advanced malignant mesothelioma was initiated based on a collaborative agreement among the Eastern Cooperative Oncology Group (ECOG), the Southwest Oncology Group (SWOG), and the Southeastern Cancer Study Group (SECSG). The purpose of the study was to evaluate cyclophosphamide (500 mg/m2 day 1), imidazole carboxamide (250 mg/m2 days 1 through 5), and doxorubicin (Adriamycin; Adria Laboratories, Columbus, OH) (50 mg/m2 day 1) v cyclophosphamide (500 mg/m2) and doxorubicin (50 mg/m2) in a randomized prospective clinical trial involving 76 fully evaluable patients with advanced stages II to IV malignant mesothelioma. A total of nine responses (12%) were documented, including three complete and six partial responses. There was no significant difference in response duration or survival between treatment arms. Leukopenia (greater than 2,000/microL) was observed in 46% of patients treated with the three-drug combination and 38% of patients receiving the two-drug combination. The variables of performance status 0-1 and the absence of prior chemotherapy/radiotherapy were significant with respect to favorable impact on survival. We conclude, based on the minimal benefit observed, that the combination of cyclophosphamide and doxorubicin with or without imidazole carboxamide does not warrant further investigation in patients with advanced-stage malignant mesothelioma.

scholarly journals LB16. The Role of Adults in the Measles Outbreak in New York State Outside of New York City, 2018–2019

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S1000-S1000
Author(s):  
Elizabeth Dufort ◽  
Dylan Johns ◽  
Manisha Patel ◽  
Manisha Patel ◽  
Nina Ahmad ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Disease Transmission ◽  
New York State ◽  
The United States ◽  
Case Definition ◽  
Material Support ◽  
Measles Outbreak ◽  
Collaborative Agreement

Abstract Background The United States is experiencing the largest measles outbreak since elimination was declared in 2000, with the majority of cases in NYS reported in undervaccinated communities. The objective of this evaluation was to describe adult measles cases in the NYS measles outbreak outside of New York City (NYC). Methods We included all confirmed cases aged ≥18 years in NYS residents (excluding NYC) during October 1, 2018–July 25, 2019 that met the CSTE measles case definition. We defined measles cases attributable to adults as the sum of measles cases among adults and children who contracted disease directly from adults. Results Among 371 confirmed measles cases, the median age was 5.5 years (range: 1 day to 64 years); 79 (21%) were in adults, 4 (5%) of whom were born before 1957 (3 unvaccinated and 1 with unknown vaccine status). Among the 75 cases born during or after 1957, 65 (87%) were unvaccinated or had unknown vaccine status, while 3 had one dose and 7 had 2 doses of measles vaccine. Notably, 5 of 11 internationally imported measles cases were adults, and all were unvaccinated or had unknown vaccine status. During the first month of the outbreak, 26 of the 51 (51%) cases were attributable to adults; of the 26, 15 (58%) were in adults and 11 (42%) were in children who acquired infection from adults (Figure 3). Conclusion The majority of measles cases occurred in unvaccinated children emphasizing the importance of ongoing and focused efforts on pediatric vaccination. However, measles cases in unvaccinated adults played an important role in both importations and disease transmission early in the outbreak. These data strongly support current recommendations of 1 dose of measles, mumps, rubella vaccine (MMR) for most adults and 2 doses of MMR for adults traveling internationally and at high-risk such as those in outbreak areas, as determined by local/state public health. Disclosures Kirsten St. George, MAppSc, PhD, Akonni Biosystems (Other Financial or Material Support), ThermoFisher (Grant/Research Support), Zeptometrix (Other Financial or Material Support, royalty generating collaborative agreement). .

Gas Chromatographic Determination of Fenvalerate Insecticide Residues in Processed Tomato Products and By-Products

1984 ◽  
Vol 67 (4) ◽  
pp. 824-826
Author(s):  
Terry D Spittler ◽  
Robert J Argauer ◽  
Donald J Lisk ◽  
Ralph O Mumma ◽  
George Winnett ◽  
...  
Keyword(s):  
Chromatographic Analysis ◽  
Fresh Produce ◽  
Chromatographic Determination ◽  
Synthetic Pyrethroid ◽  
Analytical Technique ◽  
Insecticide Residues ◽  
Collaborative Agreement ◽  
Tomato Products ◽  
By Products

Abstract The results of a 5-laboratory collaborative determination of residues of the synthetic pyrethroid insecticide fenvalerate in tomato products are presented. Tomatoes from plants treated in the field at 2-4 day intervals (13 foliar applications) were processed into chopped fresh tomatoes, canned quarters, juice, paste, and the by-product skins plus seeds. Gas chromatographic analysis of the commodities for fenvalerate showed the fresh produce to contain 0.26 ppm, and the skins plus seeds contained 1.9 ppm. Residues were barely detectable in canned peeled quarters and juice, but averaged 0.12 ppm for paste, the concentration product of juice. High residues were associated with the skin content of the product. Five laboratories using modifications of the same analytical technique obtained good collaborative agreement.

Collaboration and Supervision in Advanced Practice Nursing

2014 ◽  
Vol 7 (1) ◽  
pp. 57-62
Author(s):  
Tracy Scott ◽  
Marie Lindsey
Keyword(s):  
Nurse Practitioners ◽  
Clinical Training ◽  
District Of Columbia ◽  
The United States ◽  
Current Data ◽  
Advanced Practice Nursing ◽  
Advanced Practice ◽  
Educational Preparation ◽  
Restrictive Practice ◽  
Collaborative Agreement

Mandated collaborative or supervisory agreements are a restriction to practice for nurse practitioners (NPs) in the United States. According to the Pearson Report (Pearson, 2012), 18 states and the District of Columbia allow NPs to practice without mandated agreements. Progress toward autonomy is being made as many states remove collaborative agreement requirements. These victories are significant but many NPs continue to work in restrictive practice environments. Stiff opposition from the American Medical Association (AMA) is one obstacle to removing these restrictions. Opponents to the removal of mandated agreements cite a concern for patient safety and the educational preparation NPs receive. The evidence regarding safety is not supported by current data and a comparison of the educational requirements for NPs to other providers reveals NPs have a strong background in science and clinical training. This article explores the issues surrounding mandatory practice agreements.

scholarly journals Colophon, contents, preface

2018 ◽  
Vol 42 ◽  
Author(s):  
Jørgen A. Bojesen-Koefoed
Keyword(s):  
Lower Cretaceous ◽  
Direct Consequence ◽  
The United States ◽  
Upper Jurassic ◽  
Source Rocks ◽  
United States Geological Survey ◽  
East Greenland ◽  
North East ◽  
Industry Collaboration ◽  
Collaborative Agreement

This bulletin presents a series of nine papers dealing with the succession of Upper Jurassic – Lower Cretaceous sedimentary rocks penetrated by the fully cored Blokelv-1 borehole, drilled in western Jameson Land, central East Greenland in August 2008. The borehole was drilled as the first of three boreholes that in combination were designed to provide full coverage of the Upper Jurassic – Lower Cretaceous petroleum source-rock succession in eastern Greenland. The remaining two boreholes, Rødryggen-1 and Brorson Halvø-1, were drilled on Wollaston Forland in 2009 and 2010, respectively, and the results from these boreholes will be published in a companion volume. The objectives of the drilling campaign were fulfilled, demonstrating that continuous sedimentation of oil-prone petroleum source rocks took place in eastern Greenland over a period of c. 13 million years from the Oxfordian to the Ryazanian, with the Blokelv-1 succession representing the older, Oxfordian–Volgian part of this interval. The drilling campaign was carried out as one of a number of projects within the framework of a multi-client collaborative programme between GEUS and a long list of petroleum companies entitled Petroleum Geological Studies, Services and Data in East and Northeast Greenland. This collaboration was initiated in 2007 and is ongoing at the time of writing with more than 20 participant companies, a subset of which sponsored the studies presented herein; for contractual reasons, these companies cannot be named. The GEUS–industry collaboration was initiated in recognition of the need for new and better data on many aspects of the petroleum geology of eastern Greenland prior to an anticipated licensing round of offshore North-East Greenland. The Circum-Arctic Resource Appraisal (CARA), undertaken by the United States Geological Survey (USGS), also played an important role in defining the priorities of the collaborative agreement by directing attention towards specific subjects in need of investigation. Licensing rounds in 2012 and 2013 resulted in the award of five licences. Based on the results of these activities in eastern Greenland, a large number of scientific papers have been published since 2008, and more are expected as confidentiality clauses expire. This volume is, however, the first GEUS Bulletin to be published as a direct consequence of the GEUS–industry collaboration.

scholarly journals Characterization and Monte Carlo simulations for a CLYC detector

2018 ◽  
Vol 48 ◽  
pp. 1860115
Author(s):  
Alessandro Borella ◽  
Eric Boogers ◽  
Riccardo Rossa ◽  
Peter Schillebeeckx
Keyword(s):  
Monte Carlo ◽  
Gamma Ray ◽  
Detection System ◽  
Nuclear Material ◽  
Point Sources ◽  
Pulse Shape Discrimination ◽  
Monte Carlo Code ◽  
Nuclear Security ◽  
Collaborative Agreement ◽  
Personal Dosimetry

The CLYC (Cs[Formula: see text]LiYCl[Formula: see text]:Ce) detector is a scintillator detector sensitive to both neutron and gamma radiation and capable of separating the two types of radiation by pulse-shape discrimination. This feature is interesting as pertains to the development of non-destructive assays for the safeguard of nuclear material, nuclear security, and fast-neutron personal dosimetry. A [Formula: see text] CLYC detector highly enriched with [Formula: see text]Li was purchased and tested with analog and digital electronics. In this work, we report on the characterization of the detector in terms of linearity, energy resolution, and full-energy efficiency for gamma rays. This characterization was achieved by measurements with calibrated gamma-ray point-sources with an analog measuring chain, in a well-defined, reproducible geometry. The experimental data were also used to validate a model of the detection system that was developed with the Monte Carlo code MCNP-CP. This work is part of a collaborative agreement between SCK•CEN and JRC-Geel.

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