A portable multi-channel potentiostat for real-time amperometric measurement of multi-electrode sensor arrays

2016 ◽  
Author(s):  
Yaoxing Hu ◽  
Sanjiv Sharma ◽  
Jean Weatherwax ◽  
Anthony Cass ◽  
Pantelis Georgiou
Keyword(s):  
Real Time ◽  
Sensor Arrays ◽  
Electrode Sensor

scholarly journals Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor

2021 ◽  
Author(s):  
Jincheng Tong ◽  
Amadou Doumbia ◽  
Michael L. Turner ◽  
Cinzia Casiraghi
Keyword(s):  
Real Time ◽  
Temporal Resolution ◽  
Organic Molecules ◽  
Real Time Monitoring ◽  
Array Electrode ◽  
Electrode Sensor ◽  
Crystallization Dynamics ◽  
Interdigitated Array ◽  
Crystallization From Solution ◽  
Interdigitated Array Electrode

An Interdigitated array Electrode sensor (IES) is used for real-time monitoring of the crystallization dynamics of organic molecules, achieving a temporal resolution of 15 ms.

scholarly journals Toroidal sensor arrays for real-time photoacoustic imaging

2017 ◽  
Vol 22 (7) ◽  
pp. 076003 ◽  
Author(s):  
Anton S. Bychkov ◽  
Elena B. Cherepetskaya ◽  
Alexander A. Karabutov ◽  
Vladimir A. Makarov
Keyword(s):  
Real Time ◽  
Photoacoustic Imaging ◽  
Sensor Arrays

scholarly journals Dynamic Monitoring of Cell Adhesion and Spreading on Microelectronic Sensor Arrays

2005 ◽  
Vol 10 (8) ◽  
pp. 795-805 ◽  
Author(s):  
Josephine M. Atienza ◽  
Jenny Zhu ◽  
Xiaobo Wang ◽  
Xiao Xu ◽  
Yama Abassi
Keyword(s):  
Cell Adhesion ◽  
Cell Surface ◽  
Real Time ◽  
Specific Interaction ◽  
Sensor Arrays ◽  
Dynamic Monitoring ◽  
Cellular Interaction ◽  
Cell Surface Receptors ◽  
Label Free ◽  
Surface Receptors

Cellular interaction with and adhesion on different biological surfaces is a dynamic and integrated process requiring the participation of specialized cell surface receptors, structural proteins, signaling proteins, and the cellular cytoskeleton. In this report, the authors describe a label-free and real-time method for measuring and monitoring cell adhesion on special microplates integrated with electronic cell sensor arrays. These plates were used in conjunction with the real-time cell electronic sensing (RT-CES™) system to dynamically and quantitatively monitor the specific interaction of fibroblasts with extracellular matrix (ECM) proteins and compared with standard adhesion techniques. Cell adhesion on ECM-coated cell sensor arrays is dependent on the concentration of ECMproteins coated and is inhibited by agents that disrupt the interaction of ECM with cell surface receptors. Furthermore, the authors demonstrate that the integrity of the actin cytoskeleton is required for productive cell adhesion and spreading on ECM-coated microelectronic sensors. Confirming earlier results, it is shown that interfering with Src expression or activity, via siRNA or small molecule, results in the disruption of adhesion and spreading of Bx PC3cells. The results indicate that the RT-CES system offers a convenient and quantitative means of assessing the kinetics of cell adhesion in a high-throughput manner.

Parallel and Complementary Detection of Proteins by p-type and n-type Silicon Nanowire Transistor Arrays

2005 ◽  
Vol 900 ◽  
Author(s):  
Gengfeng Zheng ◽  
Fernando Patolsky ◽  
Charles M. Lieber
Keyword(s):  
Real Time ◽  
Field Effect Transistors ◽  
Silicon Nanowire ◽  
Sensor Arrays ◽  
Rapid Screening ◽  
Label Free ◽  
Type Silicon ◽  
Nanowire Sensor ◽  
P Type ◽  
Prostate Specific Antigens

ABSTRACTLabel-free, real-time, parallel and complementary electrical detection of proteins is demonstrated by p-type and n-type silicon nanowire field-effect transistors in the same arrays. Composed of hundreds of individually electrically addressable nanowire devices with highly sensitive and reproducible performances, these nanowire arrays can be controllably modified by monoclonal antibodies, and show discrete conductance changes characteristic of highly selective binding and unbinding of target proteins, such as prostate specific antigens (PSA), thus providing a general and powerful platform for high-throughput real-time parallel detection and rapid screening of libraries of biomolecules. Studies show that the PSA proteins can be routinely detected at femtomolar concentrations with high selectivity, and simultaneously incorporation of both p-type and n-type silicon nanowire devices enable discrimination against false positive/negative signals. The integrated complementary nanowire sensor arrays open up substantial opportunities for diagnosis and treatment of complex diseases such as cancer, detection of biological threats, and fundamental proteomic and biophysical studies.

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