The effect of biomaterial's properties on the bone cell functions

2011 ◽  
Author(s):  
Xiaoling Liao ◽  
Wenfeng Xu ◽  
Bo Li ◽  
Taifu Li ◽  
Ya Fu ◽  
...  
Keyword(s):  
Bone Cell ◽  
Cell Functions

Effects of platelet lysates on select bone cell functions

2004 ◽  
Vol 15 (5) ◽  
pp. 581-588 ◽  
Author(s):  
Emmanuel Soffer ◽  
Jean-Pierre Ouhayoun ◽  
Christine Dosquet ◽  
Alain Meunier ◽  
Fani Anagnostou
Keyword(s):  
Bone Cell ◽  
Cell Functions

scholarly journals Ca2+/Sr2+ Selectivity in Calcium-Sensing Receptor (CaSR): Implications for Strontium’s Anti-Osteoporosis Effect

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1576
Author(s):  
Diana Cheshmedzhieva ◽  
Sonia Ilieva ◽  
Eugene A. Permyakov ◽  
Sergei E. Permyakov ◽  
Todor Dudev
Keyword(s):  
Binding Sites ◽  
Density Functional ◽  
Structural Changes ◽  
Binding Pocket ◽  
Bone Cell ◽  
Therapeutic Effects ◽  
Calcium Sensing Receptor ◽  
Additional Energy ◽  
Cell Functions ◽  
Calcium Sensing

The extracellular calcium-sensing receptor (CaSR) controls vital bone cell functions such as cell growth, differentiation and apoptosis. The binding of the native agonist (Ca2+) to CaSR activates the receptor, which undergoes structural changes that trigger a cascade of events along the cellular signaling pathways. Strontium (in the form of soluble salts) has been found to also be a CaSR agonist. The activation of the receptor by Sr2+ is considered to be the major mechanism through which strontium exerts its anti-osteoporosis effect, mostly in postmenopausal women. Strontium-activated CaSR initiates a series of signal transduction events resulting in both osteoclast apoptosis and osteoblast differentiation, thus strengthening the bone tissue. The intimate mechanism of Sr2+ activation of CaSR is still enigmatic. Herewith, by employing a combination of density functional theory (DFT) calculations and polarizable continuum model (PCM) computations, we have found that the Ca2+ binding sites 1, 3, and 4 in the activated CaSR, although possessing a different number and type of protein ligands, overall structure and charge state, are all selective for Ca2+ over Sr2+. The three binding sites, regardless of their structural differences, exhibit almost equal metal selectivity if they are flexible and have no geometrical constraints on the incoming Sr2+. In contrast to Ca2+ and Sr2+, Mg2+ constructs, when allowed to fully relax during the optimization process, adopt their stringent six-coordinated octahedral structure at the expense of detaching a one-backbone carbonyl ligand and shifting it to the second coordination layer of the metal. The binding of Mg2+ and Sr2+ to a rigid/inflexible calcium-designed binding pocket requires an additional energy penalty for the binding ion; however, the price for doing so (to be paid by Sr2+) is much less than that of Mg2+. The results obtained delineate the key factors controlling the competition between metal cations for the receptor and shed light on some aspects of strontium’s therapeutic effects.

The influence of nanostructured features on bacterial adhesion and bone cell functions on severely shot peened 316L stainless steel

Biomaterials ◽  
2015 ◽  
Vol 73 ◽  
pp. 185-197 ◽  
Author(s):  
Sara Bagherifard ◽  
Daniel J. Hickey ◽  
Alba C. de Luca ◽  
Vera N. Malheiro ◽  
Athina E. Markaki ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Bacterial Adhesion ◽  
316L Stainless Steel ◽  
Bone Cell ◽  
Cell Functions

Transforming Orthopedic Biomaterials Into Bone Cancer Inhibiting Implants: The Role of Selenium Nanoclusters

2008 ◽  
Vol 1136 ◽  
Author(s):  
Phong A. Tran ◽  
Love Sarin ◽  
Robert H. Hurt ◽  
Thomas J. Webster
Keyword(s):  
Culture Media ◽  
Active Agent ◽  
Stress Shielding ◽  
Bone Cancer ◽  
Orthopedic Implants ◽  
Bone Cell ◽  
Biologically Active ◽  
Elemental Selenium ◽  
Cell Functions ◽  
Coated Surfaces

ABSTRACTCurrent orthopedic implants have numerous problems that include poor osseointegration, stress shielding and wear debris-associated bone cell death. In addition, numerous patients receive orthopedic implants as a result of bone cancer resection, yet none of the current orthopedic materials are designed to prevent either the occurrence or reoccurrence of cancer. The objective of this study was to transform a traditional orthopedic material into an implant that can both restore bone and prevent bone cancer growth at the implant-tissue interface. Elemental selenium was chosen as the biologically active agent in this material because of its known chemopreventive and chemotherapeutic properties. It was found that when selenite salts were reduced by glutathione in the presence of an immersed substrate (titanium (Ti), stainless steel (SS) or ultra high molecular weigh polyethylene (UHMWPE)), elemental selenium nucleated and grew into adherent, hemispherical nanoclusters. For each type of substrate (Ti, SS and UHMWPE), three types of surfaces with different selenium surface densities were fabricated. The zero oxidation state of selenium was confirmed on Ti substrates by XPS profiles. Compared to uncoated Ti and SS substrates, the high-density selenium-coated surfaces inhibited cancerous bone cell functions while promoting healthy bone cell functions. Very little selenium was also found to release (about 250ppb) into the cell culture media after 3 days of immersion. These findings showed for the first time the potential of using selenium nanoclusters as a coating to transform a traditional orthopedic material into a bone cancer inhibiting implant.

scholarly journals Bone cell functions in PPIB knock-out mouse model for type IX osteogenesis imperfecta are distinct from classical dominant OI

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 101005
Author(s):  
Ying Liu ◽  
Theresa Hefferan ◽  
Nadja Fratzl-Zelman ◽  
Joan Marini
Keyword(s):  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Bone Cell ◽  
Knock Out ◽  
Cell Functions ◽  
Knock Out Mouse

Frequency- and Duration-Dependent Effects of Cyclic Pressure on Select Bone Cell Functions

2001 ◽  
Vol 7 (6) ◽  
pp. 717-728 ◽  
Author(s):  
Jiro Nagatomi ◽  
Bernard P. Arulanandam ◽  
Dennis W. Metzger ◽  
Alain Meunier ◽  
Rena Bizios
Keyword(s):  
Bone Cell ◽  
Cyclic Pressure ◽  
Cell Functions
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