The Interaction Between Metrological Parameters and Industrial Process Simulation Requirements for Equipment Scale-Up/Down by means of Dimensional Analysis

2006 ◽  
Author(s):  
Fragiskos A. Batzias
Keyword(s):  
Dimensional Analysis ◽  
Process Simulation ◽  
Scale Up ◽  
Industrial Process ◽  
Metrological Parameters

Dimensional-analysis and similitude for scale-up of solid-liquid extraction of Eurycoma longifolia roots

2020 ◽  
Vol 217 ◽  
pp. 115490
Author(s):  
Noor Hafiza Harun ◽  
Azila Abdul-Aziz ◽  
Roshanida A. Rahman ◽  
Harisun Yaakub ◽  
Ramlan Aziz ◽  
...  
Keyword(s):  
Dimensional Analysis ◽  
Scale Up ◽  
Liquid Extraction ◽  
Eurycoma Longifolia ◽  
Solid Liquid Extraction ◽  
Solid Liquid

Polymorphs of Neutral Red, a Redox-Mediating Phenazine in Biological Systems

2017 ◽  
Vol 70 (9) ◽  
pp. 1032 ◽  
Author(s):  
Mackenzie Labine-Romain ◽  
Sabrina Beckmann ◽  
Mohan Bhadbhade ◽  
Saroj Bhattacharyya ◽  
Michael Manefield ◽  
...  
Keyword(s):  
Room Temperature ◽  
Control Method ◽  
Scale Up ◽  
Industrial Process ◽  
Neutral Red ◽  
Crystalline Solid ◽  
Temperature Structure ◽  
X Ray Diffraction ◽  
Methane Generation ◽  
Raman And Infrared Spectroscopy

Neutral red 1 is a heterocyclic phenazine that, as a crystalline solid, has been observed to accelerate microbial methane generation from coal. Scale-up to an industrial process will require large quantities of neutral red crystals, hence an understanding of any polymorphic behaviour is essential for careful control of this process. A room-temperature structure of 1 (Form I) has been reported previously, and this study describes a new polymorph (Form II) crystallising from aqueous solution at 50°C, or transforming from Form I over an incubation time of one week at 70°C. Single-crystal X-ray diffraction has been used to study the molecular arrangements and intermolecular interactions in the new polymorph, and compared with those found in the room temperature form. Both polymorphs have been characterised using Raman and infrared spectroscopy, and a synthetic mixture of polymorphs successfully imaged using Raman spectroscopy. Raman imaging is proposed as a quality control method for small quantities of sample to ensure the correct polymorph is produced as a feedstock for this new methanogenesis process.

TiO2 Macroscopic Fibers Bearing Outstanding Photocatalytic Properties Obtained through an Integrative Chemistry-Based Scale-Up Semi-Industrial Process

2015 ◽  
Vol 1804 ◽  
pp. 7-12
Author(s):  
Natacha Kinadjian ◽  
Mickael le Bechec ◽  
Wilfrid Neri ◽  
Philippe Poulin ◽  
Sylvie Lacombe ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Polyvinyl Alcohol ◽  
Gas Phase ◽  
Anatase Phase ◽  
Scale Up ◽  
Industrial Process ◽  
Titania Nanoparticles ◽  
Amorphous Titania ◽  
Volatile Organic ◽  
Continuous Generation

ABSTRACTIn here we depict the morphogenesis and associated properties of TiO2-based macroscopic fibers designed for the photodecomposition of volatile organic compounds (VOC). We employed a continuous industrially scalable extrusion-based process making the use of hybrid sols of amorphous titania nanoparticles, polyvinyl alcohol (PVA) and occasionally latex nanoparticles. This process allowed for the continuous generation of hybrid TiO2/latex/PVA or TiO2/PVA macroscopic fibers. Upon thermal treatment, biphasic porous fibers are obtained containing the anatase phase of TiO2 with 10-15% of brookite. These fibers, which can be manufactured under several hundred meter of length, are offering significantly improved phototocatalytic efficiency now comparable to the commercial Quartzel®PCO photocatalyst for gas-phase acetone mineralization.

scholarly journals Simulation Platform for Fault Diagnosis

2022 ◽  
pp. 45-58
Author(s):  
Jing Wang ◽  
Jinglin Zhou ◽  
Xiaolu Chen
Keyword(s):  
Fault Diagnosis ◽  
Process Simulation ◽  
Fermentation Process ◽  
Industrial Process ◽  
Simulation System ◽  
Fault Classification ◽  
Simulation Platform ◽  
Multivariate Statistical ◽  
Fault Monitoring ◽  
Statistical Analysis Methods

AbstractThe previous chapters have described the mathematical principles and algorithms of multivariate statistical methods, as well as the monitoring processes when used for fault diagnosis. In order to validate the effectiveness of data-driven multivariate statistical analysis methods in the field of fault diagnosis, it is necessary to conduct the corresponding fault monitoring experiments. Therefore this chapter introduces two kinds of simulation platform, Tennessee Eastman (TE) process simulation system and fed-batch Penicillin Fermentation Process simulation system. They are widely used as test platforms for the process monitoring, fault classification, and identification of industrial process. The related experiments based on PCA, CCA, PLS, and FDA are completed on the TE simulation platforms.

scholarly journals A droplet microfluidic platform for high-throughput photochemical reaction discovery

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra C. Sun ◽  
Daniel J. Steyer ◽  
Anthony R. Allen ◽  
Emory M. Payne ◽  
Robert T. Kennedy ◽  
...  
Keyword(s):  
High Throughput ◽  
Continuous Flow ◽  
High Throughput Screening ◽  
Resource Constraints ◽  
Scale Up ◽  
Industrial Process ◽  
Photochemical Reactions ◽  
Microfluidic Platform ◽  
Reaction Discovery ◽  
Compound Libraries

AbstractThe implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating discovery scale vial-based batch reactions to continuous flow scale-up conditions. Herein we report the development of a droplet microfluidic platform, which enables high-throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries. This platform allows for enhanced material efficiency, as reactions can be performed on picomole scale. Furthermore, high-throughput data collection via on-line ESI mass spectrometry facilitates the rapid analysis of individual, nanoliter-sized reaction droplets at acquisition rates of 0.3 samples/s. We envision this high-throughput screening platform to expand upon the robust capabilities and impact of photochemical reactions in drug discovery and development.

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