The gamma-ray scanner of a chromatographic plate for determining the radiochemical purity of radiopharmaceuticals

2012 ◽  
Author(s):  
Alexander Garapatski ◽  
Veniamin Kasakov ◽  
Ngo Van Thien
Keyword(s):  
Radiochemical Purity ◽  
Gamma Ray ◽  
Chromatographic Plate

Effect of EDTA and PYP as Co-Ligand of Radiolabeled Nanomaterial M41S-NH2 for Radiosynovectomy

2014 ◽  
Vol 896 ◽  
pp. 687-694
Author(s):  
Isti Daruwati ◽  
Maria P. Christina ◽  
Wahyu W. Perdana ◽  
Nugrahaning Wuri Hakiki ◽  
Nanny Kartini Oekar
Keyword(s):  
Room Temperature ◽  
Radiochemical Purity ◽  
Gamma Ray ◽  
Chemical Properties ◽  
Physiological Saline ◽  
Tissue Penetration ◽  
High Chemical ◽  
Chromatography Method ◽  
Similar Chemical ◽  
Chemical Purity

Radiosynovectomy is an innovative medical treatment for rheumatoid arthritis joints. A small amount of beta-emitting radiopharmaceutical is injected into the joint with intra-articullar route of administration. An ideal radionuclide for this treatment is beta emitter whose minimal gamma ray emission, tissue penetration between 5 10 mm, has short half life, high chemical purity and non-toxic properties such as Rhenium-188. For delivering the radionuclide to the specific target site in the synovial tissue and preventing the leakage to the lymph, an ideal carrier as particulate or colloidal compounds is requaired. A silica-based nanomaterial called M41S-NH2was developed as therapeutic carriers by Polytechnic Institute of Nuclear Technology, Yogyakarta. The advantage of M41S-NH2is biocompatible and not toxic to human body. As a preliminary experiment, M41S-NH2was labeled using Technetium-99m which has a similar chemical properties with Rhenium-188. The radiolabelling performed in this system is the indirect method. The purpose of this research is to obtain the highest radiochemical purity of radiolabeled99mTc-M41S-NH2by using two co-ligands such as ethylenediaminetetraasetic acid (EDTA) and sodium pyophosphate (PYP). Some parameter such as pH, ratio of SnCl2to co-ligand, ammount of reductor agent, ammount of M41S-NH2were optimized in those experiments. Radiochemical purity determination was conducted by ascending paper chromatography method using Whatman 31-ET as stationary phase and physiological saline (NaCl 0,9%) as mobile phase. The optimum condition obtained from the investigation were by using 10 μg PYP as co-ligand, 10 μg SnCl2as reductor agent, pH 9, and 10 minutes in room temperature as incubation time. More over the highest radiochemical purity obtained from those labeling experiments is 93.42± 0.06 %.

Labelling of Bleomycin with Cobalt-57, Indium-111, Technetium-99m, Mercury-197, Lead-203, and Copper-67

1976 ◽  
Vol 15 (02) ◽  
pp. 86-90 ◽  
Author(s):  
M. A. P. C van de Poll ◽  
J. J. Rasker ◽  
H. Jurjens ◽  
M. G. Woldring ◽  
A. Versluis
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Paper Chromatography ◽  
Half Life ◽  
Radiochemical Purity ◽  
Gamma Ray ◽  
Clinical Use ◽  
A Value ◽  
Indium 111 ◽  
Layer Chromatography

SummaryThe radiochemical purity of the cobalt-57 complex of bleomycin could be enhanced by adjusting the pH of the final product to a value between 5 and 6. This radiopharmaceutical appeared to have better tumor visualizing properties compared to the not neutralized preparation.The clinical use of the cobalt-57 bleomycin complex is however limited by the long physical half-life of the label, causing a risk of radioactive contamination. It appeared to be possible to label bleomycin with radioactive cations (111In3+, 99mTc4+, 197Hg2+ and 67Cu2+) having suitable gamma ray energies and short half-lifes.These bleomycin complexes showed a high radiochemical purity judged by their behaviour on thin layer chromatography, paper chromatography, and electrophoresis, but their application as tumor visualizing radiopharmaceutical turned out to be disappointing compared with cobalt-57 bleomycin.

On the possible gamma-ray source in Cygnus

1967 ◽  
Vol 31 ◽  
pp. 469-471
Author(s):  
J. G. Duthie ◽  
M. P. Savedoff ◽  
R. Cobb
Keyword(s):  
Gamma Rays ◽  
Gamma Ray ◽  
Right Ascension

A source of gamma rays has been found at right ascension 20h15m, declination +35°, with an uncertainty of 6° in each coordinate. Its flux is (1·5 ± 0·8) x 10-4photons cm-2sec-1at 100 MeV. Possible identifications are reviewed, but no conclusion is reached. The mechanism producing the radiation is also uncertain.

Solar Flare Energetic Neutral Emission Measurements in the Project Coronas-I

1994 ◽  
Vol 144 ◽  
pp. 635-639
Author(s):  
J. Baláž ◽  
A. V. Dmitriev ◽  
M. A. Kovalevskaya ◽  
K. Kudela ◽  
S. N. Kuznetsov ◽  
...  
Keyword(s):  
Solar Flare ◽  
Energy Range ◽  
Gamma Rays ◽  
Pulse Shape ◽  
Gamma Ray ◽  
Pulse Shape Discrimination ◽  
Shape Discrimination ◽  
Solar Neutron ◽  
Low Altitude

AbstractThe experiment SONG (SOlar Neutron and Gamma rays) for the low altitude satellite CORONAS-I is described. The instrument is capable to provide gamma-ray line and continuum detection in the energy range 0.1 – 100 MeV as well as detection of neutrons with energies above 30 MeV. As a by-product, the electrons in the range 11 – 108 MeV will be measured too. The pulse shape discrimination technique (PSD) is used.

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