In vitro and in vivo evaluation of a novel polymer-ceramic composite scaffold for bone tissue engineering

2006 ◽  
Author(s):  
Yusuf Khan ◽  
Saadiq F. El-Amin ◽  
Cato T. Laurencin
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Ceramic Composite ◽  
Composite Scaffold ◽  
In Vivo Evaluation

scholarly journals In Vitro and In Vivo Evaluation of Composite Scaffold of BCP, Bioglass and Gelatin for Bone Tissue Engineering

2014 ◽  
Vol 24 (6) ◽  
pp. 310-318 ◽  
Author(s):  
Woo Seok Kim ◽  
Subrata Deb Nath ◽  
Jun Sang Bae ◽  
Andrew Padalhin ◽  
Boram Kim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
In Vivo Evaluation

scholarly journals Acceleration of Bone Regeneration in Critical-Size Defect Using BMP-9-Loaded nHA/ColI/MWCNTs Scaffolds Seeded with Bone Marrow Mesenchymal Stem Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Ran Zhang ◽  
Xuewen Li ◽  
Yao Liu ◽  
Xiaobo Gao ◽  
Tong Zhu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Marrow Mesenchymal Stem Cells

Biocompatible scaffolding materials play an important role in bone tissue engineering. This study sought to develop and characterize a nano-hydroxyapatite (nHA)/collagen I (ColI)/multi-walled carbon nanotube (MWCNT) composite scaffold loaded with recombinant bone morphogenetic protein-9 (BMP-9) for bone tissue engineering by in vitro and in vivo experiments. The composite nHA/ColI/MWCNT scaffolds were fabricated at various concentrations of MWCNTs (0.5, 1, and 1.5% wt) by blending and freeze drying. The porosity, swelling rate, water absorption rate, mechanical properties, and biocompatibility of scaffolds were measured. After loading with BMP-9, bone marrow mesenchymal stem cells (BMMSCs) were seeded to evaluate their characteristics in vitro and in a critical sized defect in Sprague-Dawley rats in vivo. It was shown that the 1% MWCNT group was the most suitable for bone tissue engineering. Our results demonstrated that scaffolds loaded with BMP-9 promoted differentiation of BMMSCs into osteoblasts in vitro and induced more bone formation in vivo. To conclude, nHA/ColI/MWCNT scaffolds loaded with BMP-9 possess high biocompatibility and osteogenesis and are a good candidate for use in bone tissue engineering.

In vitro and in vivo evaluation of the marine sponge skeleton as a bone mimicking biomaterial

2015 ◽  
Vol 7 (2) ◽  
pp. 250-262 ◽  
Author(s):  
Samit K. Nandi ◽  
Biswanath Kundu ◽  
Arnab Mahato ◽  
Narsinh L. Thakur ◽  
Siddhartha N. Joardar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Marine Sponge ◽  
Marine Sponges ◽  
In Vivo Evaluation

This investigation was carried out to identify and characterize marine sponges as potential bioscaffolds in bone tissue engineering.

scholarly journals In vitro and in vivo studies of a gelatin/carboxymethyl chitosan/LAPONITE® composite scaffold for bone tissue engineering

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 54100-54110 ◽  
Author(s):  
Li Tao ◽  
Liu Zhonglong ◽  
Xiao Ming ◽  
Yang Zezheng ◽  
Liu Zhiyuan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Freeze Drying ◽  
Composite Scaffold ◽  
Carboxymethyl Chitosan ◽  
In Vivo Studies ◽  
Potential Use

In the present study, we fabricated a biocomposite scaffold composed of carboxymethyl chitosan (CMC), gelatin and LAPONITE® (Lap) nanoparticles via freeze-drying and investigated its potential use in bone tissue engineering.

High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation

Polymer ◽  
2019 ◽  
Vol 180 ◽  
pp. 121707 ◽  
Author(s):  
Jiajun Ju ◽  
Xiangfang Peng ◽  
Keqing Huang ◽  
Lengwan Li ◽  
Xianhu Liu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
High Performance ◽  
In Vivo Evaluation

scholarly journals In Vitro and In Vivo Evaluation of Carboxymethyl Cellulose Scaffolds for Bone Tissue Engineering Applications

ACS Omega ◽  
2021 ◽  
Author(s):  
Ganesan Priya ◽  
Balaraman Madhan ◽  
Uttamchand Narendrakumar ◽  
Rayadurgam Venkata Suresh Kumar ◽  
Inderchand Manjubala
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Carboxymethyl Cellulose ◽  
Engineering Applications ◽  
In Vivo Evaluation
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