Formation of adhesive contacts between neutrophils and beads coated with endothelial ligands

2003 ◽  
Author(s):  
E.B. Lomakina ◽  
R.E. Waugh
Keyword(s):  
Adhesive Contacts ◽  
Endothelial Ligands

scholarly journals Synaptic Clusters of MHC Class II Molecules Induced on DCs by Adhesion Molecule–mediated Initial T-Cell Scanning

2005 ◽  
Vol 16 (7) ◽  
pp. 3314-3322 ◽  
Author(s):  
Hortensia de la Fuente ◽  
María Mittelbrunn ◽  
Lorena Sánchez-Martín ◽  
Miguel Vicente-Manzanares ◽  
Amalia Lamana ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Regulatory Pathway ◽  
Immune Synapse ◽  
Mhc Ii ◽  
Cytoskeleton Reorganization ◽  
Adhesive Contacts ◽  
Enhance Antigen Presentation ◽  
Mhc Class Ii Molecules

Initial adhesive contacts between T lymphocytes and dendritic cells (DCs) facilitate recognition of peptide-MHC complexes by the TCR. In this report, we studied the dynamic behavior of adhesion and Ag receptors on DCs during initial contacts with T-cells. Adhesion molecules LFA-1- and ICAM-1,3-GFP as well as MHC class II-GFP molecules were very rapidly concentrated at the DC contact area. Binding of ICAM-3, and ICAM-1 to a lesser extent, to LFA-1 expressed by mature but not immature DC, induced MHC-II clustering into the immune synapse. Also, ICAM-3 binding to DC induced the activation of the Vav1-Rac1 axis, a regulatory pathway involved in actin cytoskeleton reorganization, which was essential for MHC-II clustering on DCs. Our results support a model in which ICAM-mediated MHC-II clustering on DC constitutes a priming mechanism to enhance antigen presentation to T-cells.

scholarly journals THE ELECTRON MICROSCOPY OF THE HUMAN HAIR FOLLICLE

1957 ◽  
Vol 3 (2) ◽  
pp. 223-230 ◽  
Author(s):  
M. S. C. Birbeck ◽  
E. H. Mercer
Keyword(s):  
Hair Follicle ◽  
Cross Sections ◽  
Plasma Membranes ◽  
Membrane Complex ◽  
Outer Sheath ◽  
Root Sheath ◽  
Inner Root Sheath ◽  
Cell Layers ◽  
Adhesive Contacts ◽  
Similar Complex

1. The three cylinders of cells, each one cell thick, which together constitute the inner root sheath, arise from the peripheral portions of the undifferentiated matrix. These cells, like the hair cuticle, are stabilised by the spread of adhesive contacts between their plasma membranes which occurs in the mid-bulb and upper bulb of the hair follicle. 2. The characteristic intracellular product of all three cell layers is trichohyaline. This substance is formed in the first place as amorphous droplets which subsequently transform into a birefringent form. 3. This transformation, involving the formation of a birefringent product from an amorphous precursor, is in contrast to the formation in the cortex of keratin which originates in a fibrous form. 4. Trichohyaline appears first and transforms first in the cells of Henle which are nearest the outer sheath and the dermal supply vessels. This transformation occurs at the level of the neck of the follicle. Synthesis and transformation in the cells of Huxley and the sheath cuticle lag behind the similar events in the cells of Henle. The transformation does not begin until the lower prekeratinous zone in the Huxley and cuticle cells. 5. The amorpous-fibrous transformation occurs rapidly cell by cell and involves the conversion of all the trichohyaline droplets. In longitudinal sections the birefringent modification can be seen extending from the droplets in both directions parallel to the axis of the hair. In cross-sections the images of the transformed material are difficult to interpret. They may be seen as sections of corrugated sheets (∼100 A thick) or condensed fibrils ∼100 A in width. 6. At the same time that the trichohyaline transforms, the spacing between the cell membranes increases and a dark deposit appears centrally between them. This membrane complex, and the similar complex of the hair cuticle cells described in Part 2, may be specialised formations whose purpose is to hold the hardened cells together.

Temperature-time dependence of the strength of metal - polymer adhesive contacts

1978 ◽  
Vol 13 (3) ◽  
pp. 468-471 ◽  
Author(s):  
V. R. Regel' ◽  
A. M. Leksovskii ◽  
O. F. Kireenko
Keyword(s):  
Time Dependence ◽  
Polymer Adhesive ◽  
Adhesive Contacts ◽  
Temperature Time ◽  
Metal Polymer

Extra tension at electrode-nanowire adhesive contacts in nano-electromechanical devices

2017 ◽  
Vol 66 ◽  
pp. 412-422 ◽  
Author(s):  
Alexander I. Livshits ◽  
Liga Jasulaneca ◽  
Jelena Kosmaca ◽  
Raimonds Meija ◽  
Justin D. Holmes ◽  
...  
Keyword(s):  
Electromechanical Devices ◽  
Adhesive Contacts

scholarly journals Spatial model of the gecko foot hair: functional significance of highly specialized non-uniform geometry

2015 ◽  
Vol 5 (1) ◽  
pp. 20140065 ◽  
Author(s):  
Alexander E. Filippov ◽  
Stanislav N. Gorb
Keyword(s):  
Functional Significance ◽  
Spatial Model ◽  
Rough Surfaces ◽  
Three Dimensional ◽  
Intermolecular Forces ◽  
Dimensional Structure ◽  
Fractal Surface ◽  
Flexible Form ◽  
Spatial Geometry ◽  
Adhesive Contacts

One of the important problems appearing in experimental realizations of artificial adhesives inspired by gecko foot hair is so-called clusterization. If an artificially produced structure is flexible enough to allow efficient contact with natural rough surfaces, after a few attachment–detachment cycles, the fibres of the structure tend to adhere one to another and form clusters. Normally, such clusters are much larger than original fibres and, because they are less flexible, form much worse adhesive contacts especially with the rough surfaces. Main problem here is that the forces responsible for the clusterization are the same intermolecular forces which attract fibres to fractal surface of the substrate. However, arrays of real gecko setae are much less susceptible to this problem. One of the possible reasons for this is that ends of the seta have more sophisticated non-uniformly distributed three-dimensional structure than that of existing artificial systems. In this paper, we simulated three-dimensional spatial geometry of non-uniformly distributed branches of nanofibres of the setal tip numerically, studied its attachment–detachment dynamics and discussed its advantages versus uniformly distributed geometry.

scholarly journals SIMULATION OF FRACTURE USING A MESH-DEPENDENT FRACTURE CRITERION IN THE DISCRETE ELEMENT METHOD

2018 ◽  
Vol 16 (1) ◽  
pp. 41 ◽  
Author(s):  
Andrey Dimaki ◽  
Evgeny Shilko ◽  
Sergey Psakhie ◽  
Valentin Popov
Keyword(s):  
Particle Size ◽  
Discrete Element Method ◽  
Mechanical Behavior ◽  
Fracture Criterion ◽  
Discrete Element ◽  
Macroscopic Behavior ◽  
Detachment Criterion ◽  
Discrete Element Methods ◽  
Adhesive Contacts ◽  
Fracture Processes

Recently, Pohrt and Popov have shown that for simulation of adhesive contacts a mesh dependent detachment criterion must be used to obtain the mesh-independent macroscopic behavior of the system. The same principle should be also applicable for the simulation of fracture processes in any method using finite discretization. In particular, in the Discrete Element Methods (DEM) the detachment criterion of particles should depend on the particle size. In the present paper, we analyze how the mesh dependent detachment criterion has to be introduced to guarantee the macroscopic invariance of mechanical behavior of a material. We find that it is possible to formulate the criterion which describes fracture both in tensile and shear experiments correctly.

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