Partially Observable Gene Regulatory Network Control without a Boundary on Horizon

2012 ◽  
Author(s):  
U. Erdogdu ◽  
F. Polat ◽  
R. Alhajj
Keyword(s):  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Network Control ◽  
Gene Regulatory ◽  
Partially Observable

scholarly journals Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa

Genomics ◽  
2016 ◽  
Vol 108 (3-4) ◽  
pp. 126-133 ◽  
Author(s):  
Ashley J. Vargas ◽  
John Quackenbush ◽  
Kimberly Glass
Keyword(s):  
Weight Loss ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Rectal Mucosa ◽  
Network Control ◽  
Gene Regulatory

Planning Interventions for Gene Regulatory Networks as Partially Observable Markov Decision Processes

2010 ◽  
pp. 546-572
Author(s):  
Daniel Bryce ◽  
Seungchan Kim
Keyword(s):  
Gene Regulatory Network ◽  
Gene Regulatory Networks ◽  
Regulatory Network ◽  
Regulatory Networks ◽  
Markov Decision ◽  
Gene Regulatory ◽  
Intervention Planning ◽  
Partially Observable Markov ◽  
Partially Observable ◽  
Planning Problems

In this chapter, a computational formalism for modeling and reasoning about the control of biological processes is explored. It comprises five main sections: a survey of related work, a background on methods (including discussion of the Wnt5a gene regulatory network, the coefficient of determination method for deriving gene regulatory network models, and the partially observable Markov decision process model and its role in modeling intervention planning problems), a main section on the approach taken (including algorithms for solving the intervention planning problems and techniques for representing components of the problems), an empirical evaluation of the intervention planning algorithms on synthetic and the Wnt5a gene regulatory networks, and a conclusion and future directions section. The techniques described present a promising avenue of future research in reasoning algorithms for improved scalability in planning interventions in gene regulatory networks.

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