Study of a novel ultra-short electrical pulse generator

Introduction: Vagus nerve stimulation is a palliative treatment for patients with refractory epilepsy to reduce the frequency and intensity of seizures. A bipolar helical electrode is placed around the left vagus nerve at the cervical level and is connected to the pulse generator placed in a subcutaneous pocket, most commonly in the subclavian region. Methods: Between March 1998 and October 2019, we performed 196 procedures related to the vagal nerve stimulation at the Neurosurgery Department in Motol University Hospital. Of these, 126 patients were vagal nerve stimulator implantation surgeries for intractable epilepsy. The cases included 69 female and 57 male patients with mean age at the time of the implantation surgery 22±12.4 years (range 2.1−58.4 years). Results: Nine patients (7.1%) were afflicted by complications related to implantation. Surgical complications included postoperative infection in 1.6%, VNS-associated arrhythmias in 1.6%, jugular vein bleeding in 0.8% and vocal cord paresis in 2.4%. One patient with vocal cord palsy also suffered from severe dysphagia. One patient (0.8%) did not tolerate extra stimulation with magnet due to a prolonged spasm in his throat. The extra added benefit of vagus stimulation in one patient was a significant reduction of previously regular severe headaches. Conclusion: Vagus nerve stimulation is an appropriate treatment for patients with drug-resistant epilepsy who are not candidates for focal resective surgery. Implantation of the vagus nerve stimulator is a relatively safe operative procedure.

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Androgenic and oestrogenic steroid participation in feedback control of luteinizing hormone secretion in male sheep

Acta Endocrinologica ◽

10.1530/acta.0.1020499 ◽

1983 ◽

Vol 102 (4) ◽

pp. 499-504 ◽

Cited By ~ 15

Author(s):

M. J. D'Occhio ◽

B. D. Schanbacher ◽

J. E. Kinder

Keyword(s):

Luteinizing Hormone ◽

Pulse Generator ◽

Hormone Secretion ◽

Pulse Interval ◽

Serum Concentrations ◽

Luteinizing Hormone Secretion ◽

Lh Release ◽

Lh Secretion ◽

Additional Feedback ◽

Male Sheep

Abstract. The acute castrate ram (wether) was used as an experimental model to investigate the site(s) of feedback on luteinizing hormone (LH) by testosterone, dihydrotestosterone and oestradiol. At the time of castration, wethers were implanted subdermally with Silastic capsules containing either crystalline testosterone (three 30 cm capsules), dihydrotestosterone (five 30 cm capsules) or oestradiol (one 6.5 cm capsule). Blood samples were taken at 10 min intervals for 6 h 2 weeks after implantation to determine serum steroid concentrations and to characterize the patterns of LH secretion. Pituitary LH response to exogenous LRH (5 ng/kg body weight) were also determined at the same time. The steroid implants produced serum concentrations of the respective hormones which were either one-third (testosterone) or two-to-four times (dihydrotestosterone, oestradiol) the levels measured in rams at the time of castration. Non-implanted wethers showed rhythmic pulses of LH (pulse interval 40–60 min) and had elevated LH levels (16.1 ± 1.6 ng/ml; mean ± se) 2 weeks after castration. All three steroids suppressed pulsatile LH release and reduced mean LH levels (to below 3 ng/ml) and pituitary LH responses to LRH. Inhibition of pulsatile LH secretion by all three steroids indicated that testosterone as well as its androgenic and oestrogenic metabolites can inhibit the LRH pulse generator in the hypothalamus. Additional feedback on the pituitary was indicated by the dampened LH responses to exogenous LRH.

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Consideration of Core Material of Burst Pulse Generator with Magnetic Switch Type Nonlinear Transmission Line

IEEJ Transactions on Fundamentals and Materials ◽

10.1541/ieejfms.139.307 ◽

2019 ◽

Vol 139 (6) ◽

pp. 307-308

Author(s):

Hiromi Sato ◽

Keita Yasu ◽

Yasushi Minamitani

Keyword(s):

Transmission Line ◽

Pulse Generator ◽

Core Material ◽

Magnetic Switch ◽

Nonlinear Transmission Line ◽

Nonlinear Transmission ◽

Switch Type ◽

Burst Pulse

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DESIGN OF HIGH PERFORMANCE PULSE GENERATOR TO PERFORM AUTOMATIC TEST IN VLSI CIRCUITS

i-manager’s Journal on Electronics Engineering ◽

10.26634/jele.9.3.15953 ◽

2019 ◽

Vol 9 (3) ◽

pp. 26

Author(s):

P. LOKESH ◽

V. THRIMURTHULU ◽

PRIYA L. MIHIRA ◽

◽

...

Keyword(s):

High Performance ◽

Pulse Generator ◽

Vlsi Circuits ◽

Automatic Test

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WAVE KINETICS OF POWDERS CONSOLIDATION BY HIGH-VOLTAGE ELECTRICAL PULSE

8th International Symposium on Nonequilibrium Processes, Plasma, Combustion, and Atmospheric Phenomena held Том. Volum 1. Kinetics and plasma ◽

10.30826/nepcap2018-1-17 ◽

2018 ◽

Author(s):

E. G. GRIGORYEV ◽

◽

D. O. MOSKOVSKIKH ◽

Keyword(s):

High Voltage ◽

Electrical Pulse ◽

Kinetics Of

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SELECTION OF THE DRIVE OF THE PULSE GENERATOR FOR WAVE DEFORMATION HARDENING

PROBLEMS OF APPLIED MECHANICS ◽

10.30987/conferencearticle_5fd1ed04240555.15450088 ◽

2020 ◽

Author(s):

Andrey Kirichek ◽

Dmitriy Solovyev

Keyword(s):

Strain Hardening ◽

Pulse Generator ◽

Surface Plastic Deformation ◽

Surface Plastic ◽

Impact Frequency ◽

Metal Consumption ◽

Pulse Generators ◽

Energy Impact ◽

Deformation Hardening ◽

Selection Of

The article is devoted to the analysis of known structures of impact devices used in industry in order to obtain recommendations for their adaptation or when creating new structures for wave strain hardening by surface plastic deformation. The analysis was carried out on the used drive and on the main parameters of impact devices: impact energy, impact frequency, relative metal consumption and efficiency. The options are the best combinations of parameters for electric, pneumatic and hydraulic drives. Recommendations are given on the use of such devices, with appropriate adaptation, as pulse generators for wave strain hardening.

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