Modeling the heart defect of transposition of the great arteries using the PHYSBE model

Author(s):  
Mohamad Amin Bakhshali ◽  
Sabalan Daneshvar ◽  
Mahsa Mafi
Keyword(s):  
Author(s):  
Maria Cristina Digilio ◽  
Bruno Marino ◽  
Salvatore A. Canepa ◽  
Umberto Borzaga ◽  
Aldo Giannotti ◽  
...  

2016 ◽  
Vol 1 ◽  
pp. 68-71
Author(s):  
Ireneusz Haponiuk ◽  
Katarzyna Gierat-Haponiuk ◽  
Dominika Szalewska ◽  
Piotr Niedoszytko ◽  
Stanisław Bakuła ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Reiner Buchhorn ◽  
Christian Müller ◽  
Christian Willaschek ◽  
Kambiz Norozi

Background. Although stimulants have long been touted as treatments for attention deficit disorder with or without hyperactivity (ADHD), in recent years, increasing concerns have been raised about the cardiovascular safety of these medications. We aimed to prove if measurements of autonomic function with time domain analysis of heart rate variability (HRV) in 24-hour Holter ECG are useful to predict the risk of sudden cardiac death in ADHD children and adolescents. Methods. We analysed HRV obtained from children with the diagnosis of ADHD prior to (N=12) or during medical therapy (N=19) with methylphenidate (MPH), aged 10.8±2.0 years (mean ± SD), who were referred to our outpatient Paediatric Cardiology Clinic to rule out heart defect. As a control group, we compared the HRV data of 19 age-matched healthy children without heart defect. Results. Average HRV parameters from 24-hour ECG in the ADHD children prior to MPH showed significant lower values compared to healthy children with respect to rMSSD (26±4 ms versus 44±10 ms, P≤0.0001) and pNN50 (6.5±2.7% versus 21.5±9.0%, P≤0.0001). These values improved in MPH-treated children with ADHD (RMSSD: 36±8 ms; pNN50: 14.2±6.9%). Conclusion. Children who suffer from ADHD show significant changes in HRV that predominantly reflects diminished vagal tone, a well-known risk factor of sudden cardiac death in adults. In our pilot study, MPH treatment improved HRV.


2003 ◽  
Vol 117A (1) ◽  
pp. 83-84 ◽  
Author(s):  
Maria Leine Guion-Almeida ◽  
Nancy Mizue Kokitsu-Nakata

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