RFIDSLT: A Data Lineage Tracing Method for Complex Query over RFID Streams

2009 ◽  
Author(s):  
Yongli Wang ◽  
Jiang-Bo Qian ◽  
Ran Ma
Keyword(s):  
Lineage Tracing ◽  
Complex Query ◽  
Data Lineage ◽  
Tracing Method

scholarly journals A High-Fidelity Cell Lineage Tracing Method for Obtaining Systematic Spatiotemporal Gene Expression Patterns inCaenorhabditis elegans

2013 ◽  
Vol 3 (5) ◽  
pp. 851-863 ◽  
Author(s):  
Daniel L Mace ◽  
Peter Weisdepp ◽  
Louis Gevirtzman ◽  
Thomas Boyle ◽  
Robert H Waterston
Keyword(s):  
Gene Expression ◽  
Expression Patterns ◽  
Cell Lineage ◽  
Lineage Tracing ◽  
Gene Expression Patterns ◽  
High Fidelity ◽  
Tracing Method

scholarly journals Olfactory neuron turnover in adult Drosophila

2020 ◽  
Author(s):  
Ismael Fernández-Hernández ◽  
Eric Hu ◽  
Michael A. Bonaguidi
Keyword(s):  
Sensory Neurons ◽  
Olfactory Epithelium ◽  
Olfactory System ◽  
Lineage Tracing ◽  
Olfactory Neuron ◽  
Neuronal Regeneration ◽  
Continuous Generation ◽  
The Brain ◽  
Adult Drosophila ◽  
Tracing Method

ABSTRACTSustained neurogenesis occurs in the olfactory epithelium of several species, including humans, to support olfactory function throughout life. We recently developed a modified lineage tracing method to identify adult neurogenesis in Drosophila. By applying this technique, here we report on the continuous generation of Olfactory Sensory Neurons (OSN) in the antennae of adult Drosophila. New neurons develop sensory dendrites and project axons targeting diverse glomeruli of the antennal lobes in the brain. Furthermore, we identified sustained apoptosis of OSN in the antennae of adult flies, revealing unexpected turnover in the adult olfactory system. Our results substantiate Drosophila as a compelling platform to expedite research about mechanisms and compounds promoting neuronal regeneration, circuit remodeling and its contribution to behavior in the adult.

scholarly journals Repressing PTB is incapable to convert reactive astrocytes to dopaminergic neurons in a mouse model of Parkinson's disease

2021 ◽  
Author(s):  
Weizhao Chen ◽  
Qiongping Zheng ◽  
Qiaoying Huang ◽  
Shanshan Ma ◽  
Mingtao Li
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Dopaminergic Neurons ◽  
Lineage Tracing ◽  
Reactive Astrocytes ◽  
Reactive Astrocyte ◽  
Adeno Associated Virus ◽  
Polypyrimidine Tract Binding Protein ◽  
Tracing Method

Lineage reprograming of resident glia cells to induced dopaminergic neurons (iDAns) holds attractive prospect for cell-replacement therapy of Parkinson's disease (PD). Recently, whether repressing polypyrimidine tract binding protein (PTB) could truly achieve efficient astrocyte-to-iDAn conversion in substantia nigra and striatum aroused widespread controversy. Although reporter+ iDAns were observed by two groups after delivering adeno-associated virus (AAV) expressing a reporter with shRNA or Crispr-CasRx to repress astroglial PTB, the possibility of AAV leaking into endogenous DAns could not be excluded without using a reliable lineage tracing method. By adopting stringent lineage tracing strategy, two other studies showed that neither knockdown nor genetic deletion of quiescent astroglial PTB fails to obtain iDAns under physiological condition. However, the role of reactive astrocyte might be underestimated since upon brain injury, reactive astrocyte could acquire certain stem cell hallmarks which may facilitate the lineage conversion process. Therefore, whether reactive astrocytes could be genuinely converted to DAns after PTB repression in a PD model needs further validation. In this study, we used Aldh1l1-CreERT2-mediated specific astrocyte-lineage tracing method to investigate whether reactive astrocytes could be converted to DAns in the 6-OHDA PD model. However, we found that no astrocyte-originated DAns was generated after effective knockdown of astroglial PTB either in the substantia nigra or in the striatum, while AAV leakage to nearby neurons was observed. Our results further confirmed that repressing PTB is unable to convert astrocytes to DA neurons no matter in physiological or PD-related pathological conditions.

scholarly journals Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Keisuke Tanaka ◽  
Junichi Tanaka ◽  
Ryo Aizawa ◽  
Mayu Kato-Tanaka ◽  
Hiroo Ueno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bacterial Infections ◽  
Alveolar Bone ◽  
Basal Layer ◽  
Lineage Tracing ◽  
Tooth Surface ◽  
Cell Populations ◽  
Periodontal Tissue ◽  
Junctional Epithelium ◽  
Tracing Method

AbstractThe junctional epithelium (JE) is an epithelial component that attaches directly to the tooth surface and performs the unique function of protecting against bacterial infections; its destruction causes inflammation of the periodontal tissue and loss of alveolar bone. A recent study that used the single-color lineage tracing method reported that JE is maintained by its stem cells. However, the process by which individual stem cells form the entire JE around a whole tooth remains unclear. Using a 4-color lineage tracing method, we performed a detailed examination of the dynamics of individual stem cells that constitute the entire JE. The multicolor lineage tracing method showed that single-color areas, which were derived from each cell color, replaced all the constituent JE cells 168 d after the administration of tamoxifen. The horizontal section of the first molar showed that the single-color areas in the JE expanded widely. We detected putative stem cells at the external basal layer farthest from the enamel. In this study, JE cells that were supplied from different stem cells were visualized as individual monochromatic regions, and the JE around the first molar was maintained by several JE-specific stem cells. These findings indicated that the JE consisted of several cell populations that were supplied from their multiple stem cells and could help to explore the mechanisms involved in periodontal tissue homeostasis.

Lineage tracing of Nkx2.2-expressing cells by novel genetically-defined lineage tracing method in chick spinal cord

2010 ◽  
Vol 68 ◽  
pp. e370
Author(s):  
Hitoshi Goto ◽  
Katsuhiko Ono ◽  
Hirohide Takebayashi ◽  
Hidekiyo Harada ◽  
Harukazu Nakamura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Lineage Tracing ◽  
Tracing Method ◽  
Chick Spinal Cord

Field Estimation in Tunnel and Underground by Ray Tracing Method

2000 ◽  
Vol 54 (3) ◽  
pp. 46-56
Author(s):  
K. Uchida ◽  
D. Da ◽  
C. K. Lee ◽  
T. Matsunaga ◽  
T. Imai ◽  
...  
Keyword(s):  
Ray Tracing ◽  
Ray Tracing Method ◽  
Field Estimation ◽  
Tracing Method
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