Service-Enabled Automatic Framework for Testing and Tuning Multi-tier System

2008 ◽  
Author(s):  
Dong Jun Lan ◽  
Pei Ni Liu ◽  
Jun Hou ◽  
Meng Ye ◽  
Leslie S. Liu
Keyword(s):  
Tier System

A Refined Framework for Precision and Translational Proteomics in Clinical Research

2020 ◽  
Vol 17 ◽  
Author(s):  
Min Wang ◽  
Daozhen Chen ◽  
Yankai Xia ◽  
Tao Zhou ◽  
Shi-Wen Jiang
Keyword(s):  
Data Interpretation ◽  
Clinical Proteomics ◽  
Experimental Procedure ◽  
Clinical Biomarkers ◽  
Experimental Variation ◽  
Tier System ◽  
Initial Discovery ◽  
Translational Studies ◽  
Potential Biomarkers

: Most clinical related proteomic studies were aimed to screen potential biomarkers for clinical usage. However, it is known that only a few candidates could be validated in later stages. Besides clinical biomarkers, it also necessary to identify key proteins to better understand the molecular mechanism of human diseases. Here, we updated the connotations of precision and translational proteomics and proposed a refined research framework for clinical proteomics. We abstracted the framework as a three-tier system: to determine research objective and approach for achieving a certain purpose, to choose the appropriate methods for optimal results, and to apply standardized experimental procedure for reliable and reproducible results. Started from the initial discovery stage, we divided the following proteomics-driven translational studies into two directions: biomarker screening and mechanism investigation. We also discussed possible causes that may lead to high rates of experimental variation and low rates of follow-up validation. Moreover, we pointed out that the main bottlenecks for the identification of effective targets are data interpretation and statistical inference. Finally, we emphasized that the transparency of experimental design and results can help to ensure data quality. Conclusively, the refined framework provides constructive recommendations and comprehensive guides for designing and performing clinical related proteomic studies with the aim of obtaining reliable and reproducible results. It can also help to further promote the standardization and integration of proteomic studies.

The Problems of Ignorance and Uncertainty

2018 ◽  
Author(s):  
Holly M. Smith
Keyword(s):  
Decision Makers ◽  
Lower Tier ◽  
Theoretical Account ◽  
Hybrid Approaches ◽  
Tier System ◽  
Special Case

Chapter 9 turns to further epistemic barriers for decision makers: the problems of (nonmoral) ignorance and (nonmoral) uncertainty. The concepts of “ignorance” and “uncertainty” are elucidated, the problem of uncertainty is defined, and it is argued that the problem of ignorance should be treated as a special case of the problem of uncertainty. The three salient attempts to solve the problem are the Pragmatic, Austere, and Hybrid approaches. Combined solutions to the problem of error and the problem of uncertainty are explored, and it is argued that the only feasible approaches marry the Austere Response to the problem of error with the Hybrid Response to the problem of uncertainty in a two-tier system. The top-tier code provides the correct theoretical account of right and wrong, while the lower-tier rules provide associated decision-guides. Consistency requires that different normative terms be used by the top-tier rules and by the lower-tier rules.

scholarly journals Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Larry Carbone
Keyword(s):  
United States ◽  
Animal Welfare ◽  
The United States ◽  
Animal Research ◽  
Government Agencies ◽  
Laboratory Rats ◽  
Tier System ◽  
Western Nations ◽  
Rats And Mice ◽  
Usage Data

AbstractAlone among Western nations, the United States has a two-tier system for welfare protections for vertebrate animals in research. Because its Animal Welfare Act (AWA) excludes laboratory rats and mice (RM), government veterinarians do not inspect RM laboratories and RM numbers are only partially reported to government agencies1. Without transparent statistics, it is impossible to track efforts to reduce or replace these sentient animals’ use or to project government resources needed if AWA coverage were expanded to include them. I obtained annual RM usage data from 16 large American institutions and compared RM numbers to institutions’ legally-required reports of their AWA-covered mammals. RM comprised approximately 99.3% of mammals at these representative institutions. Extrapolating from 780,070 AWA-covered mammals in 2017–18, I estimate that 111.5 million rats and mice were used per year in this period. If the same proportion of RM undergo painful procedures as are publicly reported for AWA-covered animals, then some 44.5 million mice and rats underwent potentially painful experiments. These data inform the questions of whether the AWA needs an update to cover RM, or whether the NIH should increase transparency of funded animal research. These figures can benchmark progress in reducing animal numbers in general and more specifically, in painful experiments. This estimate is higher than any others available, reflecting the challenges of obtaining statistics without consistent and transparent institutional reports.

scholarly journals Modelling the impact of the tier system on SARS-CoV-2 transmission in the UK between the first and second national lockdowns

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e050346
Author(s):  
Daniel J Laydon ◽  
Swapnil Mishra ◽  
Wes R Hinsley ◽  
Pantelis Samartsidis ◽  
Seth Flaxman ◽  
...  
Keyword(s):  
Real Time ◽  
Reproduction Number ◽  
Secondary Outcome ◽  
Bayesian Hierarchical ◽  
Time Reproduction ◽  
Tier System ◽  
The Uk ◽  
National Trends ◽  
Tier 3 ◽  
The Impact

ObjectiveTo measure the effects of the tier system on the COVID-19 pandemic in the UK between the first and second national lockdowns, before the emergence of the B.1.1.7 variant of concern.DesignThis is a modelling study combining estimates of real-time reproduction number Rt (derived from UK case, death and serological survey data) with publicly available data on regional non-pharmaceutical interventions. We fit a Bayesian hierarchical model with latent factors using these quantities to account for broader national trends in addition to subnational effects from tiers.SettingThe UK at lower tier local authority (LTLA) level. 310 LTLAs were included in the analysis.Primary and secondary outcome measuresReduction in real-time reproduction number Rt.ResultsNationally, transmission increased between July and late September, regional differences notwithstanding. Immediately prior to the introduction of the tier system, Rt averaged 1.3 (0.9–1.6) across LTLAs, but declined to an average of 1.1 (0.86–1.42) 2 weeks later. Decline in transmission was not solely attributable to tiers. Tier 1 had negligible effects. Tiers 2 and 3, respectively, reduced transmission by 6% (5%–7%) and 23% (21%–25%). 288 LTLAs (93%) would have begun to suppress their epidemics if every LTLA had gone into tier 3 by the second national lockdown, whereas only 90 (29%) did so in reality.ConclusionsThe relatively small effect sizes found in this analysis demonstrate that interventions at least as stringent as tier 3 are required to suppress transmission, especially considering more transmissible variants, at least until effective vaccination is widespread or much greater population immunity has amassed.

A 3-tier classification of cerebral arteriovenous malformations

2011 ◽  
Vol 114 (3) ◽  
pp. 842-849 ◽  
Author(s):  
Robert F. Spetzler ◽  
Francisco A. Ponce
Keyword(s):  
Surgical Outcomes ◽  
Arteriovenous Malformations ◽  
Neurological Deficits ◽  
Cerebral Arteriovenous Malformations ◽  
Pooled Data ◽  
Class A ◽  
Tier System ◽  
Class B ◽  
Class C

Object The authors propose a 3-tier classification for cerebral arteriovenous malformations (AVMs). The classification is based on the original 5-tier Spetzler-Martin grading system, and reflects the treatment paradigm for these lesions. The implications of this modification in the literature are explored. Methods Class A combines Grades I and II AVMs, Class B are Grade III AVMs, and Class C combines Grades IV and V AVMs. Recommended management is surgery for Class A AVMs, multimodality treatment for Class B, and observation for Class C, with exceptions to the latter including recurrent hemorrhages and progressive neurological deficits. To evaluate whether combining grades is warranted from the perspective of surgical outcomes, the 3-tier system was applied to 1476 patients from 7 surgical series in which results were stratified according to Spetzler-Martin grades. Results Pairwise comparisons of individual Spetzler-Martin grades in the series analyzed showed the fewest significant differences (p < 0.05) in outcomes between Grades I and II AVMs and between Grades IV and V AVMs. In the pooled data analysis, significant differences in outcomes were found between all grades except IV and V (p = 0.38), and the lowest relative risks were found between Grades I and II (1.066) and between Grades IV and V (1.095). Using the pooled data, the predictive accuracies for surgical outcomes of the 5-tier and 3-tier systems were equivalent (receiver operating characteristic curve area 0.711 and 0.713, respectively). Conclusions Combining Grades I and II AVMs and combining Grades IV and V AVMs is justified in part because the differences in surgical results between these respective pairs are small. The proposed 3-tier classification of AVMs offers simplification of the Spetzler-Martin system, provides a guide to treatment, and is predictive of outcome. The revised classification not only simplifies treatment recommendations; by placing patients into 3 as opposed to 5 groups, statistical power is markedly increased for series comparisons.

Improved ZF-like Intra-Tier Precoder for A VFDM Based Two-Tier System

2018 ◽  
Author(s):  
Rugui Yao ◽  
Pengfei Jiang ◽  
Lukun Yao ◽  
Yan Gao ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Tier System

scholarly journals Role of the Elected Panchayat Samity Members in National Health and Family Welfare Programs: A Case Study

2014 ◽  
Author(s):  
Subhash Barman
Keyword(s):  
State Government ◽  
National Health ◽  
Rural Areas ◽  
Geographical Area ◽  
Family Welfare ◽  
Welfare Programs ◽  
Tier System ◽  
Agrarian Communities ◽  
Block Level

The geographical area of this study is West Bengal - a constituent state (province) of India. The state government policy aims at administrative decentralization through Panchayats (or Village Councils) in rural areas. It is a 3-tier system, comprising a Gram Panchayat in every village, Panchayat Samity (block level), and Zilla Parishad (district level). Focusing mainly on Panchayat Samity members, the study explores the knowledge, attitudes, participation, and involvement of the Panchayat Samity members in National Health and Family Welfare Programs. The categories of respondents are the Health Committee members of Panchayat Samity, and health personnel of Block Primary Health Center and Rural Hospital. With a positive frame of mind, they are found to be involved in promoting awareness about health and family planning, and in providing child immunization and other health measures to predominantly agrarian communities.

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