Measurement of mechanical properties of human saphenous vein using an inflation experiment

2013 ◽  
Author(s):  
Farzad Forouzandeh ◽  
Mahdie Haji Bozorgi ◽  
Behrooz Meshkat ◽  
Nasser Fatouraee
Keyword(s):  
Mechanical Properties ◽  
Saphenous Vein ◽  
Human Saphenous Vein ◽  
Inflation Experiment

scholarly journals Comparison between mechanical properties of human saphenous vein and umbilical vein

2012 ◽  
Vol 11 (1) ◽  
pp. 59 ◽  
Author(s):  
Borhan Alhosseini Hamedani ◽  
Mahdi Navidbakhsh ◽  
Hossein Ahmadi Tafti
Keyword(s):  
Mechanical Properties ◽  
Saphenous Vein ◽  
Umbilical Vein ◽  
Human Saphenous Vein

UNIAXIAL AND BIAXIAL MECHANICAL PROPERTIES OF THE HUMAN SAPHENOUS VEIN

2015 ◽  
Vol 27 (05) ◽  
pp. 1550050 ◽  
Author(s):  
Aisa Rassoli ◽  
Nasser Fatouraee ◽  
Mohammad Shafigh
Keyword(s):  
Mechanical Properties ◽  
Saphenous Vein ◽  
Artery Bypass ◽  
Young Modulus ◽  
Biaxial Stress ◽  
Type Model ◽  
Special Importance ◽  
Mathematical Function ◽  
Human Saphenous Vein ◽  
Biaxial Tests

Cardiovascular diseases are one of the major causes of death in the world and are closely related to blood dynamics and wall mechanical properties of vessels. This makes the study of mechanical properties of arteries and veins essential. In this regard, study on common vessels used in bypass grafting operations is of special importance due to the frequency of this surgery. Human saphenous vein is one of the vessels used for bypass surgeries. The objective of the present study is to characterize the behavior of human saphenous vein using uniaxial and biaxial planar tests. Forty human saphenous samples were obtained after coronary artery bypass surgery (CABG). The planar tensile tests were performed on the tissue specimens by applying loads along two directions. These tests provided the force-displacement curves. The stress-strain curves from uniaxial tests were modeled with a mathematical function and the Young modulus was obtained in both longitudinal and circumferential directions. Measured data of uniaxial tests were then fitted into a hyperelastic four-parameter Fung-type model and also an isotropic Mooney–Rivlin model. The biaxial stress-stretch curves were fitted to a hyperelastic anisotropic four-parameter Fung-type model and a five-parameter Mooney–Rivlin model. The specimens showed some degrees of anisotropy. In both uniaxial and biaxial tests, specimens showed stiffer behaviour in longitudinal as opposed to circumferential directions. The stretch ratio in the circumferential direction was much higher than in the longitudinal orientation.

scholarly journals Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery

Biomaterials ◽  
2009 ◽  
Vol 30 (8) ◽  
pp. 1542-1550 ◽  
Author(s):  
Gerhardt Konig ◽  
Todd N. McAllister ◽  
Nathalie Dusserre ◽  
Sergio A. Garrido ◽  
Corey Iyican ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Blood Vessels ◽  
Saphenous Vein ◽  
Human Tissue ◽  
Human Saphenous Vein ◽  
Tissue Engineered Blood Vessels

scholarly journals High stretch induces endothelial dysfunction accompanied by oxidative stress and actin remodeling in human saphenous vein endothelial cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
T. Girão-Silva ◽  
M. H. Fonseca-Alaniz ◽  
J. C. Ribeiro-Silva ◽  
J. Lee ◽  
N. P. Patil ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
Saphenous Vein ◽  
Saphenous Vein Graft ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Human Saphenous Vein ◽  
Actin Remodeling

AbstractThe rate of the remodeling of the arterialized saphenous vein conduit limits the outcomes of coronary artery bypass graft surgery (CABG), which may be influenced by endothelial dysfunction. We tested the hypothesis that high stretch (HS) induces human saphenous vein endothelial cell (hSVEC) dysfunction and examined candidate underlying mechanisms. Our results showed that in vitro HS reduces NO bioavailability, increases inflammatory adhesion molecule expression (E-selectin and VCAM1) and THP-1 cell adhesion. HS decreases F-actin in hSVECs, but not in human arterial endothelial cells, and is accompanied by G-actin and cofilin’s nuclear shuttling and increased reactive oxidative species (ROS). Pre-treatment with the broad-acting antioxidant N-acetylcysteine (NAC) supported this observation and diminished stretch-induced actin remodeling and inflammatory adhesive molecule expression. Altogether, we provide evidence that increased oxidative stress and actin cytoskeleton remodeling play a role in HS-induced saphenous vein endothelial cell dysfunction, which may contribute to predisposing saphenous vein graft to failure.

Phenotype Gradation of Human Saphenous Vein Endothelial Cells from Cardiovascular Disease Subjects

Endothelium ◽  
2006 ◽  
Vol 13 (5) ◽  
pp. 341-352 ◽  
Author(s):  
C. Krishna Prasad ◽  
K. Jayakumar ◽  
Lissy K. Krishnan
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Saphenous Vein ◽  
Human Saphenous Vein
Sign in / Sign up

Export Citation Format

Share Document