Formulation, Characterization and Evaluation of the in Vitro Skin Permeation of Nanostructured Lipid Carriers Encapsulated Tripterine

2012 ◽  
Author(s):  
Yan Chen ◽  
Lei Zhou ◽  
Ling Yuan ◽  
Zhenhai Zhang ◽  
Qingqing Wu
Keyword(s):  
Skin Permeation ◽  
Nanostructured Lipid Carriers ◽  
In Vitro Skin Permeation

Transdermal Delivery of Metoprolol II: In-Vitro Skin Permeation and Bioavailability in Hairless Rats

1995 ◽  
Vol 84 (2) ◽  
pp. 158-160 ◽  
Author(s):  
Tapash K. Ghosh ◽  
Joseph Adir ◽  
Si‐Ling Xiang ◽  
Samuel Onyilofur
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
In Vitro Skin Permeation

In vitro skin permeation of buprenorphine transdermal patch

2020 ◽  
Vol 16 (6) ◽  
Author(s):  
C.-L. Liao ◽  
C.-C. Huang ◽  
C.-Y. Lee ◽  
T.-H. Chiu ◽  
S.-C. Kuo ◽  
...  
Keyword(s):  
Skin Permeation ◽  
Transdermal Patch ◽  
In Vitro Skin Permeation

scholarly journals FORMULATION AND DEVELOPMENT OF TRANSDERMAL DRUG DELIVERY SYSTEM OF ETHINYLESTRADIOL AND TESTOSTERONE: IN VITRO EVALUATION

2019 ◽  
Vol 11 (1) ◽  
pp. 55
Author(s):  
Shikha Baghel Chauhan ◽  
Tanveer Naved ◽  
Nayyar Parvez
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Skin Permeation ◽  
Physical Parameters ◽  
Transdermal Patch ◽  
Transdermal Drug Delivery System ◽  
In Vitro Skin Permeation

Objective: The combination therapy of ethinylestradiol and testosterone in post-menopausal females has shown improved sexual response and libido. The present studies were designed to develop a suitable matrix-type transdermal drug delivery system (TDDS) of ethinylestradiol and testosterone using the polymer chitosan.Methods: Five formulations (ET1 to ET5) were developed by varying the concentration of polymer and keeping the drug load constant. Physical parameters and drug excipient interaction studies were evaluated in all the formulations. In vitro skin permeation profiles of ethinylestradiol and testosterone from various formulations were simultaneously characterized in a thermostatically controlled modified Franz Diffusion cell using HPLC. Based on the physical parameters and in vitro skin permeation profile formulation ET3 containing 30 mg/ml of chitosan was found to be the best and chosen for further studies. Optimized formulation was subjected to in vivo pharmacokinetic analysis in rats using ELISA.Results: Stability profile of patch formulation ET3 depicted stability up to 3 mo. One week skin irritation evaluation in rats indicated that formulation ET3 was nonirritating. Combination transdermal patch across rat skin showed a maximum release of 92.936 and 95.03 % in 60 h with a flux of 2.088 and 21.398 µg/cm2h for ethinylestradiol and testosterone respectively.Conclusion: The net result of this study is the formulation of a stable, non-irritating transdermal patch of ethinylestradiol and testosterone, with good bioavailability and can be used as Estrogen Replacement Therapy (ERT) in postmenopausal women.

scholarly journals Enhancing effect of modified beta-cyclodextrins on in vitro skin permeation of estradiol

2007 ◽  
Vol 43 (1) ◽  
pp. 111-120 ◽  
Author(s):  
Daniel De Paula ◽  
Dionéia Camilo Rodrigues Oliveira ◽  
Antônio Cláudio Tedesco ◽  
Maria Vitória Lopes Badra Bentley
Keyword(s):  
Skin Permeation ◽  
Enhancing Effect ◽  
In Vitro Skin Permeation
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