Apoptosis-Inducing Effect of Caspase-3 Over-Expressed on Gastric Cancer Cell Line SGC7901

2008 ◽  
Author(s):  
Jun Zhao ◽  
Shi-Ying Zheng ◽  
De-Chun Li ◽  
Jin-Feng Ge
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Caspase 3 ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line

scholarly journals The Cytotoxic Effects of Testosterone on Gastric Cancer Cell Line (AGS) and Evaluation of Caspase-3, -8, and -9 Activity

2019 ◽  
Vol 13 (6) ◽  
pp. 8-17
Author(s):  
Neda Amani ◽  
Mehrdad Shariati ◽  
Rahim Ahmadi ◽  
Saeed Khatamsaz ◽  
Mokhtar Mokhtari ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Caspase 3 ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Cytotoxic Effects

scholarly journals Inhibitory effect of Gypsophila oldhamiana gypsogenin on NCI-N87 gastric cancer cell line

2018 ◽  
Vol 16 ◽  
pp. 205873921881895
Author(s):  
Yutao Liu ◽  
Xu Li ◽  
Shanling Jiang ◽  
Quanli Ge
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Caspase 3 ◽  
Tumor Volume ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Inhibitory Effect ◽  
High Dose

Gastric cancer is one of the major cancers threatening people’s lives worldwide. Recent studies showed that Gypsophila oldhamiana gypsogenin (GOG) exhibits inhibition effects and cytotoxic activities against different cell lines. The aim of this study was to explore the inhibitory effect and dose response of GOG on gastric cancer cell line NCI-N87 and to provide the theoretical basis for clinical anti-tumor therapy. The experiments showed that GOG could inhibit the proliferation and promote the apoptosis of human gastric cancer cell line NCI-N87. GOG could dose dependently reduce the expression of vascular endothelial growth factor (VEGF) and matrix metalloprotein (MMP)-9 proteins, while increase the expression of caspase-3 and Bax proteins. Compared with model group, tumor volume (TV), relative tumor volume (RTV), and relative tumor increment rate (T/C) in the mid-dose and high-dose GOG groups were significantly reduced, and the inhibition rate (IR) in the two groups was significantly increased. The results indicated that the anti-tumor effect of GOG on gastric cancer cells may be related with the downregulation of caspase-3 and Bax and the upregulation of MMP-9 and VEGF.

scholarly journals Enhanced Vasculogenic Capacity Induced by 5-Fluorouracil Chemoresistance in a Gastric Cancer Cell Line

2021 ◽  
Vol 22 (14) ◽  
pp. 7698
Author(s):  
Sara Peri ◽  
Alessio Biagioni ◽  
Giampaolo Versienti ◽  
Elena Andreucci ◽  
Fabio Staderini ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Intracellular Signaling ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Tumor Evolution ◽  
Selective Growth Advantage

Chemotherapy is still widely used as a coadjutant in gastric cancer when surgery is not possible or in presence of metastasis. During tumor evolution, gatekeeper mutations provide a selective growth advantage to a subpopulation of cancer cells that become resistant to chemotherapy. When this phenomenon happens, patients experience tumor recurrence and treatment failure. Even if many chemoresistance mechanisms are known, such as expression of ATP-binding cassette (ABC) transporters, aldehyde dehydrogenase (ALDH1) activity and activation of peculiar intracellular signaling pathways, a common and universal marker for chemoresistant cancer cells has not been identified yet. In this study we subjected the gastric cancer cell line AGS to chronic exposure of 5-fluorouracil, cisplatin or paclitaxel, thus selecting cell subpopulations showing resistance to the different drugs. Such cells showed biological changes; among them, we observed that the acquired chemoresistance to 5-fluorouracil induced an endothelial-like phenotype and increased the capacity to form vessel-like structures. We identified the upregulation of thymidine phosphorylase (TYMP), which is one of the most commonly reported mutated genes leading to 5-fluorouracil resistance, as the cause of such enhanced vasculogenic ability.

scholarly journals Downregulation of c-Met expression does not enhance the sensitivity of gastric cancer cell line MKN-45 to gefitinib

2014 ◽  
Vol 11 (3) ◽  
pp. 2269-2275 ◽  
Author(s):  
JIN-AN MA ◽  
CHUNHONG HU ◽  
WENJUAN LI ◽  
JING REN ◽  
FANGWEN ZOU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line

scholarly journals Establishment of an α-Fetoprotein-producing Gastric Cancer Cell Line in Serum-free Media

1991 ◽  
Vol 82 (8) ◽  
pp. 883-885 ◽  
Author(s):  
Masanori Terashima ◽  
Kenichiro Ikeda ◽  
Chihaya Maesawa ◽  
Hidenobu Kawamura ◽  
Yorikazu Niitsu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Serum Free ◽  
Free Media
Sign in / Sign up

Export Citation Format

Share Document