A Segmentation Method for Bone Marrow Cavity Imaging Using Graph Cuts

2014 ◽  
Author(s):  
Tomohiro Mashita ◽  
Jun Usam ◽  
Hironori Shigeta ◽  
Yoshihiro Kuroda ◽  
Junichi Kikuta ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Graph Cuts ◽  
Segmentation Method ◽  
Marrow Cavity ◽  
Bone Marrow Cavity

scholarly journals Bone marrow cavity segmentation using graph-cuts with wavelet-based texture feature

2017 ◽  
Vol 15 (05) ◽  
pp. 1740004 ◽  
Author(s):  
Hironori Shigeta ◽  
Tomohiro Mashita ◽  
Junichi Kikuta ◽  
Shigeto Seno ◽  
Haruo Takemura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Image Segmentation ◽  
Pattern Classification ◽  
Graph Cuts ◽  
Support Vector ◽  
Segmentation Method ◽  
Spatial Continuity ◽  
Marrow Cavity ◽  
Texture Pattern ◽  
Bone Marrow Cavity

Emerging bioimaging technologies enable us to capture various dynamic cellular activities [Formula: see text]. As large amounts of data are obtained these days and it is becoming unrealistic to manually process massive number of images, automatic analysis methods are required. One of the issues for automatic image segmentation is that image-taking conditions are variable. Thus, commonly, many manual inputs are required according to each image. In this paper, we propose a bone marrow cavity (BMC) segmentation method for bone images as BMC is considered to be related to the mechanism of bone remodeling, osteoporosis, and so on. To reduce manual inputs to segment BMC, we classified the texture pattern using wavelet transformation and support vector machine. We also integrated the result of texture pattern classification into the graph-cuts-based image segmentation method because texture analysis does not consider spatial continuity. Our method is applicable to a particular frame in an image sequence in which the condition of fluorescent material is variable. In the experiment, we evaluated our method with nine types of mother wavelets and several sets of scale parameters. The proposed method with graph-cuts and texture pattern classification performs well without manual inputs by a user.

A bone marrow cavity segmentation method using wavelet-based texture feature

2016 ◽  
Author(s):  
Hironori Shigeta ◽  
Tomohiro Mashita ◽  
Junichi Kikuta ◽  
Shigeto Seno ◽  
Haruo Takemura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Texture Feature ◽  
Segmentation Method ◽  
Marrow Cavity ◽  
Bone Marrow Cavity

The Bone Marrow Cavity Is Suitable for Islet Transplantation in Diabetic Rhesus Monkey.

2014 ◽  
Vol 98 ◽  
pp. 360-361
Author(s):  
L. Yan-rong ◽  
C. Wang ◽  
X. Du ◽  
S. He ◽  
Y. Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rhesus Monkey ◽  
Islet Transplantation ◽  
Marrow Cavity ◽  
Bone Marrow Cavity

Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice

Blood ◽  
2000 ◽  
Vol 95 (11) ◽  
pp. 3363-3370 ◽  
Author(s):  
Hisashi Tagaya ◽  
Takahiro Kunisada ◽  
Hidetoshi Yamazaki ◽  
Toshiyuki Yamane ◽  
Takeshi Tokuhisa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Strains ◽  
B Lymphopoiesis ◽  
Hematopoietic Growth Factors ◽  
Newborn Mice ◽  
Marrow Cavity ◽  
Interleukin 7 ◽  
Neonatal Stage ◽  
Bone Marrow Cavity ◽  
B Lineage

Adult bone marrow is a major site for hematopoiesis, and reduction of the bone marrow cavity induces hematopoiesis in extramarrow tissues. To investigate the rudimentary intramarrow and the compensatory extramarrow hematopoiesis, particularly B lymphopoiesis, we used 3 osteopetrotic mouse strains [op/op, mi/mi, and Fos(−/−)], which are severely deficient in functional osteoclasts and therefore form inadequate bone marrow cavities. We found that bone marrow in these osteopetrotic mice supports myelopoiesis but not B lymphopoiesis, although cells that have the potential to differentiate into B lineage cells are present in the bone marrow. Although B lymphopoiesis normally occurs both in the spleen and liver of newborn mice, compensatory B lymphopoiesis in adultop/op and mi/mi mice is observed only in the liver, while myelopoiesis is enhanced in both organs. Interestingly, mice lacking the Fos proto-oncogene exhibit B lymphopoiesis in the spleen as well as liver. The amounts of expression of steel factor, Flt3/Flk-2 ligand, and interleukin-7 in the bone marrow, spleen, or liver were not significantly affected in these osteopetrotic mutants. These findings suggest that the volume of the bone marrow cavity regulates B lymphopoiesis without affecting the production of certain hematopoietic growth factors. The splenic microenvironments that support both myelopoiesis and B lymphopoiesis in the neonatal stage are lost in adults and are not reactivated even in the osteopetrotic adults unless the Fos gene is disrupted.

Expression of bone sialoprotein mRNA during bone formation and resorption induced by colchicine in rat tibial bone marrow cavity

2009 ◽  
Vol 10 (8) ◽  
pp. 1209-1217 ◽  
Author(s):  
N. Arai ◽  
K. Ohya ◽  
S. Kasugai ◽  
H. Shimokawa ◽  
S. Ohida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Sialoprotein ◽  
Marrow Cavity ◽  
Tibial Bone ◽  
Bone Marrow Cavity

scholarly journals Changes in the structural organization of bone after amputation

2020 ◽  
Author(s):  
Viktor Ivanovych Shevchuk ◽  
Yurii Oleksiiovych Bezsmertnyi ◽  
Halyna Viktorivna Vezsmertna ◽  
Tetyana Viktorivna Dovgalyuk ◽  
Yankai Jiang
Keyword(s):  
Bone Marrow ◽  
Structural Organization ◽  
Muscle Tension ◽  
Bone Plate ◽  
Tight Closure ◽  
Marrow Cavity ◽  
Normal Bone ◽  
Reparative Process ◽  
Bone Marrow Cavity ◽  
Series Of Experiments

Introduction: Despite a considerable amount of work on limb amputations, questions of the mechanism and conditions for the occurrence of pathological rearrangement in the bone stump and ways to prevent it remain unexplored. Aim: To study the nature of changes in the structural organization of bone stump after amputation. Material and methods: Nine series of experiments were conducted on 129 rabbits with amputation of the thigh and closure of the filing with fascia, muscles with varying degrees of tension and a bone plate. Duration of observation is 1, 3, and 6 months. The research method is histological with a filling of blood vessels with a mascara-gelatin mixture. Results and discussion: Tight closure of the bone marrow cavity and uniform muscle tension during plastic surgery in the I–III series of experiments make it possible to obtain cylindrical stumps with the formation of a bone closure plate and the completion of the reparative process. In the majority of observations of the IV–IX series, significant violations of the structural organization of the bone occurred in the form of conical, club-shaped, swollen stumps, creeping fractures. Conclusions: The rapid completion of the reparative process and the normalization of intraosseous circulation with a locking bone plate, while maintaining normal bone marrow tissue, is possible only with a dense closure of the filing. The lack of tight closure of the bone marrow canal and uneven muscle tension cause a violation of regeneration with changes in the structural organization of the bone. These changes are manifested by a thickening of the bone diameter, axis curvature, creeping fractures.

Intramarrow injection needle: a new technique to treat patients with haematological and non-haematological malignancies by directly injecting therapeutic agents into the bone marrow cavity

2020 ◽  
Vol 73 (9) ◽  
pp. 552-556
Author(s):  
Anwarul Islam
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Therapeutic Agents ◽  
External Diameter ◽  
Blood Products ◽  
Intravenous Therapy ◽  
Marrow Cavity ◽  
New Instrument ◽  
Bone Marrow Cavity ◽  
A New Technique

AimsThe purpose of this report is to describe a new instrument designed for the injection of therapeutic agents directly into the bone marrow cavity as well as to aspirate bone marrow specimens for the diagnostic purposes.MethodsThe instrument consists of three parts: the needle, stilette and an adjustable guard. The overall length of the needle is 76 mm and has uniform external diameter except for the distal penetrating segment, which is sharp but short and safe to use on the sternum. The proximal end of the needle is fitted with a plastic T-bar handle, which is ergonomically designed for firm grip and easy manoeuvrability.ResultsThe instrument has been designed to obtain bone marrow aspirate specimens as well as to inject therapeutic agents into the posterior ilium.ConclusionsThe rationale for the intramedullary injection of therapeutic agents for the treatment of patients with leukaemia, lymphoma and other haematological and non-haematological malignant disorders is described. In an emergency when intravenous therapy becomes difficult due to collapsed veins, this instrument may be used for direct intramarrow infusion of blood and blood products.

Sign in / Sign up

Export Citation Format

Share Document