Computational Investigation of Protein Chemistry: “S-Nitrosohemoglobin”

2008 ◽  
Author(s):  
Denise M. Koch ◽  
Ann M. English ◽  
Gilles H. Peslherbe
Keyword(s):  
Protein Chemistry ◽  
Computational Investigation

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

1985 ◽  
Vol 43 ◽  
pp. 726-729
Author(s):  
K.S. Kosik ◽  
L.K. Duffy ◽  
S. Bakalis ◽  
C. Abraham ◽  
D.J. Selkoe
Keyword(s):  
Monoclonal Antibodies ◽  
Alzheimer Disease ◽  
Human Brain ◽  
Neurofibrillary Tangles ◽  
Morphological Analysis ◽  
High Specificity ◽  
Cytoskeletal Proteins ◽  
Neuritic Plaque ◽  
Protein Chemistry ◽  
Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

COMPUTATIONAL INVESTIGATION OF DIMPLE EFFECTS ON HEAT TRANSFER AND FRICTION FACTOR IN A LAMILLOY COOLING STRUCTURE

2015 ◽  
Vol 22 (2) ◽  
pp. 147-175 ◽  
Author(s):  
Lei Luo ◽  
Chenglong Wang ◽  
Lei Wang ◽  
Bengt Sunden ◽  
Songtao Wang
Keyword(s):  
Heat Transfer ◽  
Friction Factor ◽  
Computational Investigation

In silico ADME, Bioactivity and Toxicity Parameters Calculation of Some Selected Anti-Tubercular Drugs

2016 ◽  
Vol 6 (6) ◽  
pp. 77 ◽  
Author(s):  
Shashank Shekhar Mishra ◽  
Chandra Shekhar Sharma ◽  
Hemendra Pratap Singh ◽  
Harshda Pandiya ◽  
Neeraj Kumar
Keyword(s):  
Antibiotic Resistance ◽  
In Silico ◽  
Bacillus Calmette Guerin ◽  
Computational Investigation ◽  
Pharmacological Profile ◽  
In Silico Toxicity ◽  
Is Development ◽  
Potent Drug ◽  
Minimal Resistance ◽  
Parameters Calculation

Tuberculosis, one of the most frequent infectious diseases, is caused by a mycobacterium tuberculosis bacteria and it infects several hundred million people each year, results in several million deaths annually. Because there is development of antibiotic resistance, the disease becomes incurable. So, in the absence of effective and potent drug with minimal resistance problems, the mortality rate increases annually. In this computational investigation, we performed In-silico ADME, bioactivity and toxicity parameters calculation of some selected anti-tuberculosis agents. To design a new molecule having good pharmacological profile, this study will provide the lead information.Key Words: Tuberculosis (TB), Bacillus Calmette-Guerin vaccine, TPSA, In Silico toxicity

Experimental and computational investigation of supersonic impinging jets

AIAA Journal ◽  
2002 ◽  
Vol 40 ◽  
pp. 599-609 ◽  
Author(s):  
F. S. Alvi ◽  
J. A. Ladd ◽  
W. Bower
Keyword(s):  
Impinging Jets ◽  
Computational Investigation

Initial Computational Investigation Toward Passive Transition Delay Using a Phononic Subsurface

2021 ◽  
Author(s):  
Caleb J. Barnes ◽  
Carson L. Willey ◽  
Kevin Rosenberg ◽  
Albert Medina ◽  
Abigail T. Juhl
Keyword(s):  
Computational Investigation ◽  
Passive Transition ◽  
Transition Delay
Sign in / Sign up

Export Citation Format

Share Document