Task Allocation and Migration Algorithm for Temperature-Constrained Real-Time Multi-Core Systems

2010 ◽  
Author(s):  
Guowei Wu ◽  
Zichuan Xu ◽  
Qiufen Xia ◽  
Jiankang Ren ◽  
Feng Xia
Keyword(s):  
Real Time ◽  
Task Allocation ◽  
And Migration

Platelet-Derived Exosomes Affect the Proliferation and Migration of Human Umbilical Vein Endothelial Cells Via miR-126

2019 ◽  
Vol 17 (4) ◽  
pp. 379-387 ◽  
Author(s):  
Yan Sun ◽  
Xiao-li Liu ◽  
Dai Zhang ◽  
Fang Liu ◽  
Yu-jing Cheng ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Real Time ◽  
Umbilical Vein ◽  
Angiogenic Factors ◽  
Healthy Donors ◽  
And Migration ◽  
Umbilical Vein Endothelial Cells ◽  
Tgf Β1 ◽  
Proliferation And Migration

Background:Intraplaque angiogenesis, the process of generating new blood vessels mediated by endothelial cells, contributes to plaque growth, intraplaque hemorrhage, and thromboembolic events. Platelet-derived Exosomes (PLT-EXOs) affect angiogenesis in multiple ways. The ability of miR-126, one of the best-characterized miRNAs that regulates angiogenesis, carried by PLT-EXOs to influence angiogenesis via the regulation of the proliferation and migration of endothelial cells is unknown. In this study, we aimed to investigate the effects of PLT-EXOs on angiogenesis by Human Umbilical Vein Endothelial Cells (HUVECs).Methods:We evaluated the levels of miR-126 and angiogenic factors in PLT-EXOs from Acute Coronary Syndrome (ACS) patients and healthy donors by real-time Polymerase Chain Reaction (PCR) and western blotting. We incubated HUVECs with PLT-EXOs and measured cell proliferation and migration with the Cell Counting Kit-8 assay and scratch assay, respectively. We also investigated the expression of miR-126 and angiogenic factors in HUVECs after exposure to PLT-EXOs by western blotting and real-time PCR.Results:PLT-EXOs from ACS patients contained higher levels of miR-126 and angiogenic factors, including Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), and Transforming Growth Factor Beta 1 (TGF-β1), than those from healthy donors (p<0.05). Moreover, the levels of exosomal miR-126 and angiogenic factors were increased after stimulation with thrombin (p<0.01). HUVEC proliferation and migration were promoted by treatment with activated PLT-EXOs (p<0.01); they were accompanied by the over-expression of miR-126 and angiogenic factors, including VEGF, bFGF, and TGF-β1 (p<0.01).Conclusion:Activated PLT-EXOs promoted the proliferation and migration of HUVECs, and the overexpression of miR-126 and angiogenic factors, thereby elucidating potential new therapeutic targets for intraplaque angiogenesis.

Designing Multiplayer Online Games Using the Real-Time Framework

2012 ◽  
pp. 290-321 ◽  
Author(s):  
Sergei Gorlatch ◽  
Frank Glinka ◽  
Alexander Ploss ◽  
Dominik Meiländer
Keyword(s):  
Real Time ◽  
Computer Games ◽  
Wide Spectrum ◽  
Online Games ◽  
Special Focus ◽  
Single Server ◽  
Multiplayer Online Games ◽  
Multiple Servers ◽  
Game State ◽  
And Migration

This chapter describes a novel, high-level approach to designing and executing online computer games. The approach is based on our Real-Time Framework (RTF) and suits a wide spectrum of online games including Massively Multiplayer Online Games (MMOG) and First-Person Shooters (FPS). The authors address major design issues like data structures and Area of Interest (AoI), with a special focus on the scalability of games implemented on multiple servers, including distribution of the game state, inter-server communication, object serialization and migration, etc. The chapter illustrates the approach with two case studies: the design of a new multi-player online game and bringing the single-server commercial game Quake 3 to multiple servers in order to increase the number of simultaneous players. The authors show the place of their approach in the taxonomy of game development approaches, and they report experimental results on the performance of games developed using RTF.

scholarly journals The Differential Expression of miRNAs and a Preliminary Study on the Mechanism of miR-194-3p in Keloids

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Zhishan Xu ◽  
Bingyu Guo ◽  
Peng Chang ◽  
Qiang Hui ◽  
Wei Li ◽  
...  
Keyword(s):  
Western Blot ◽  
Real Time ◽  
Differential Expression ◽  
Real Time Pcr ◽  
Luciferase Reporter ◽  
Luciferase Reporter Gene ◽  
Cultured Fibroblasts ◽  
Gene Assay ◽  
And Migration ◽  
Related Proteins

The aim of this study was to detect abnormally expressed microRNA (miRNA) in keloids and to study their functions. The differential expression of miRNAs in keloids and normal tissue was detected by gene microarray. MiRNA expression was verified by real-time PCR. A luciferase reporter gene assay, western blot, and real-time PCR were used to detect the effect of miR-194-3p on RUNX2. An MTT assay and a transwell assay were used to detect the effect of miR-194-3p in both primary cultured fibroblasts and HKF cells. Related proteins were analysed by western blot and real-time PCR. The expression of miR-194-3p was lower in keloids, and MiR-194-3p was shown to target RUNX2 directly. MiR-194-3p inhibited the proliferation and migration of fibroblasts through the inhibition of CDK4 and MMP2. MiR-194-3p and RUNX2 may become new targets for the prevention and treatment of keloids.

scholarly journals Effects of enamel matrix proteins on adherence, proliferation and migration of epithelial cells: A real-time in vitro study

2016 ◽  
Vol 13 (1) ◽  
pp. 160-168 ◽  
Author(s):  
Marzena Wyganowska-Swiatkowska ◽  
Paulina Urbaniak ◽  
Daniel Lipinski ◽  
Marlena Szalata ◽  
Karolina Borysiak ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Real Time ◽  
In Vitro Study ◽  
Vitro Study ◽  
Matrix Proteins ◽  
Enamel Matrix ◽  
Enamel Matrix Proteins ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals A mutual-selecting market-based mechanism for dynamic coalition formation

2018 ◽  
Vol 15 (1) ◽  
pp. 172988141875584 ◽  
Author(s):  
Bing Xie ◽  
Shaofei Chen ◽  
Jing Chen ◽  
LinCheng Shen
Keyword(s):  
Real Time ◽  
Coalition Formation ◽  
Task Allocation ◽  
Completion Rate ◽  
Utilization Rate ◽  
Task Completion ◽  
Distributed Agents ◽  
Time Task ◽  
Comparable Performance ◽  
Negotiation Mechanism

This article presents a novel market-based mechanism for a dynamic coalition formation problem backgrounded under real-time task allocation. Specifically, we first analyze the main factors of the real-time task allocation problem, and formulate the problem based on the coalition game theory. Then, we employ a social network for communication among distributed agents in this problem, and propose a negotiation mechanism for agents forming coalitions on timely emerging tasks. In this mechanism, we utilize an auction algorithm for real-time agent assignment on coalitions, and then design a mutual-selecting method to acquire better performance on agent utilization rate and task completion rate. And finally, our experimental results demonstrate that our market-based mechanism has a comparable performance in task completion rate to a decentralized approach (within 25% better on average) and a centralized dynamic coalition formation method (within 10% less on average performance).

scholarly journals A new load balancing strategy by task allocation in edge computing based on intermediary nodes

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Guangshun Li ◽  
Yonghui Yao ◽  
Junhua Wu ◽  
Xiaoxiao Liu ◽  
Xiaofei Sheng ◽  
...  
Keyword(s):  
Load Balancing ◽  
Real Time ◽  
Task Allocation ◽  
Normal Load ◽  
Task Assignment ◽  
Edge Computing ◽  
Heavy Load ◽  
Light Load ◽  
Assignment Model ◽  
Classification Evaluation

AbstractThe latency of cloud computing is high for the reason that it is far from terminal users. Edge computing can transfer computing from the center to the network edge. However, the problem of load balancing among different edge nodes still needs to be solved. In this paper, we propose a load balancing strategy by task allocation in edge computing based on intermediary nodes. The intermediary node is used to monitor the global information to obtain the real-time attributes of the edge nodes and complete the classification evaluation. First, edge nodes can be classified to three categories (light-load, normal-load, and heavy-load), according to their inherent attributes and real-time attributes. Then, we propose a task assignment model and allocate new tasks to the relatively lightest load node. Experiments show that our method can balance load among edge nodes and reduce the completion time of tasks.

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