Improved swarm intelligence solution in large scale radiation therapy inverse planning

2015 ◽  
Author(s):  
Arezoo Modiri ◽  
Xuejun Gu ◽  
Aaron Hagan ◽  
Amit Sawant
Keyword(s):  
Radiation Therapy ◽  
Swarm Intelligence ◽  
Large Scale ◽  
Inverse Planning

The Survival of Patients with Inoperable Lung Cancer: A Large-Scale Randomized Study of Radiation Therapy Versus Placebo

Radiology ◽  
1968 ◽  
Vol 90 (4) ◽  
pp. 688-697 ◽  
Author(s):  
Bernard Roswit ◽  
Mary Ellen Patno ◽  
Robert Rapp ◽  
Arnolds Veinbergs ◽  
Bernard Feder ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Large Scale ◽  
Randomized Study

scholarly journals A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

2020 ◽  
Vol 21 (5) ◽  
pp. 1619 ◽  
Author(s):  
Xiaomin Yang ◽  
Daniela Salado-Leza ◽  
Erika Porcel ◽  
César R. González-Vargas ◽  
Farah Savina ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Gamma Rays ◽  
Metallic Nanoparticles ◽  
Large Scale ◽  
Molecular Probe ◽  
Water Radiolysis ◽  
Fluorescence Lifetime Imaging ◽  
One Pot ◽  
Fluorescent Markers ◽  
Cervical Cancer Cells

Nanomedicine has stepped into the spotlight of radiation therapy over the last two decades. Nanoparticles (NPs), especially metallic NPs, can potentiate radiotherapy by specific accumulation into tumors, thus enhancing the efficacy while alleviating the toxicity of radiotherapy. Water radiolysis is a simple, fast and environmentally-friendly method to prepare highly controllable metallic nanoparticles in large scale. In this study, we used this method to prepare biocompatible PEGylated (with Poly(Ethylene Glycol) diamine) platinum nanoflowers (Pt NFs). These nanoagents provide unique surface chemistry, which allows functionalization with various molecules such as fluorescent markers, drugs or radionuclides. The Pt NFs were produced with a controlled aggregation of small Pt subunits through a combination of grafted polymers and radiation-induced polymer cross-linking. Confocal microscopy and fluorescence lifetime imaging microscopy revealed that Pt NFs were localized in the cytoplasm of cervical cancer cells (HeLa) but not in the nucleus. Clonogenic assays revealed that Pt NFs amplify the gamma rays induced killing of HeLa cells with a sensitizing enhancement ratio (SER) of 23%, thus making them promising candidates for future cancer radiation therapy. Furthermore, the efficiency of Pt NFs to induce nanoscopic biomolecular damage by interacting with gamma rays, was evaluated using plasmids as molecular probe. These findings show that the Pt NFs are efficient nano-radio-enhancers. Finally, these NFs could be used to improve not only the performances of radiation therapy treatments but also drug delivery and/or diagnosis when functionalized with various molecules.

scholarly journals Adenocarcinoma of the Sinonasal Tract: A Review of the National Cancer Database

2019 ◽  
Vol 81 (06) ◽  
pp. 701-708
Author(s):  
Neil N. Patel ◽  
Ivy W. Maina ◽  
Edward C. Kuan ◽  
Vasiliki Triantafillou ◽  
Michal A. Trope ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Large Scale ◽  
Critical Role ◽  
Stage Iv ◽  
Sinonasal Tract ◽  
Interdisciplinary Management ◽  
Advanced Tumor Stage ◽  
National Cancer Database ◽  
Advanced Tumor ◽  
Rare Malignancy

Abstract Background Sinonasal adenocarcinoma (SNAC) is a rare malignancy arising from mucus-secreting glandular tissue. Limited large-scale studies are available due to its rarity. We evaluated SNAC in the National Cancer Database (NCDB), a source that affords multi-institutional, population studies of rare cancers and their outcomes. Methods The NCDB was queried for adenocarcinoma in the sinonasal tract. Multivariate analyses were performed to evaluate for factors contributing to overall survival (OS). Results A total of 553 patients were identified. The cohort was composed of 59.3% males. The nasal cavity was the most common primary site, representing 44.1% of cases. About 5.7% of patients presented with nodal disease, while 3.3% had distant metastases. About 40.6% of cases presented with stage IV disease. About 73.5% of patients underwent surgery, 54.2% received radiation therapy, and 27.7% had chemotherapy. Median OS was 71.7 months, while OS at 1, 2, and 5 years was 82, 73.0, and 52%, respectively. On multivariate analysis, advanced age (hazard ratio [HR]: 1.04; 95% confidence interval [CI]: 1.02–1.05), Charlson–Deyo score of 1 (HR: 1.99; 95% CI: 1.20–3.30), advanced tumor grade (HR: 2.73; 95% CI: 1.39–5.34), and advanced tumor stage (HR: 2.71; 95% CI: 1.33–5.50) were associated with worse OS, whereas surgery (HR: 0.34; 95% CI: 0.20–0.60) and radiation therapy (HR: 0.55; 95% CI: 0.33–0.91), but not chemotherapy (HR: 1.16; 95% CI: 0.66–2.05), predicted improved OS. Conclusions SNAC is a rare malignancy with 5-year survival approximating 50%. Surgery and radiation therapy, but not chemotherapy, are associated with improved survival, and likely play a critical role in the interdisciplinary management of SNAC.

Comparison of three IMRT inverse planning techniques that allow for partial esophagus sparing in patients receiving thoracic radiation therapy for lung cancer

2004 ◽  
Vol 29 (3) ◽  
pp. 210-216 ◽  
Author(s):  
Ying Xiao ◽  
Maria Werner-Wasik ◽  
D. Michalski ◽  
C. Houser ◽  
G. Bednarz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Planning Techniques ◽  
Inverse Planning ◽  
Thoracic Radiation

scholarly journals Inverse Planning Optimization Method for Intensity Modulated Radiation Therapy

2013 ◽  
Vol 12 (5) ◽  
pp. 391-401
Author(s):  
Yihua Lan ◽  
Haozheng Ren ◽  
Cunhua Li ◽  
Zhifang Min ◽  
Jinxin Wan ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Optimization Method ◽  
Inverse Planning ◽  
Intensity Modulated ◽  
Planning Optimization
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