A Time-efficient Test Rig for Thermal Characterisation of Electric Machines and Manufacturing Process Development

2019 ◽  
Author(s):  
Yufeng Guo ◽  
Juliette Soulard ◽  
David Greenwood
Keyword(s):  
Manufacturing Process ◽  
Process Development ◽  
Electric Machines ◽  
Test Rig ◽  
Efficient Test

Manufacturing Process Development for Thin Film Filaments as a New Product

2020 ◽  
pp. 513-522
Author(s):  
Bahadır Tunaboylu ◽  
Biset Toprak ◽  
Ahmet Korhan Binark ◽  
Osman Öztürk ◽  
Selim Zaim
Keyword(s):  
Thin Film ◽  
Manufacturing Process ◽  
Process Development ◽  
New Product

Generic Modular Operations for Virtual Manufacturing Process Engineering

1997 ◽  
Author(s):  
David E. Lee ◽  
H. Thomas Hahn
Keyword(s):  
Manufacturing Process ◽  
Process Development ◽  
Process Engineering ◽  
Virtual Manufacturing ◽  
Control Approach ◽  
Computational Costs ◽  
Direct Mechanism ◽  
Novel Approach ◽  
Operation Control ◽  
Virtual Process

Abstract In order to address the computational costs of modeling and analyzing manufacturing processes, a novel approach to virtual manufacturing process engineering using generic modular operations is presented. Relying on a state based representation of operation control for a simplified virtual manufacturing workcell, the valid states for each sequence of generic modular operations are aggregated and both operation state and processing constraints applied to specify the subtasks required to complete each step in a product’s process plan. By adopting this state based control approach, virtual process engineering provides a direct mechanism to map virtual process representations onto actualized processes. Using these generic modular operations and their temporal and processing dependencies, the computationally complex elements of virtual manufacturing process simulation can be directly identified and an architecture for virtual process development specified. Examples from both machining and assembly processes are provided.

Environment for thin-film manufacturing process development for product engineering of micro and nano devices

2009 ◽  
Author(s):  
Dirk Ortloff ◽  
Kai Hahn ◽  
Jens Popp ◽  
Thilo Schmidt ◽  
Rainer Brück
Keyword(s):  
Thin Film ◽  
Manufacturing Process ◽  
Process Development ◽  
Product Engineering

Q-SA√ESS: a methodology to help solvent selection for pharmaceutical manufacture at the early process development stage

2016 ◽  
Vol 18 (24) ◽  
pp. 6564-6572 ◽  
Author(s):  
Valerio Isoni ◽  
Loretta L. Wong ◽  
Hsien H. Khoo ◽  
Iskandar Halim ◽  
Paul Sharratt
Keyword(s):  
Manufacturing Process ◽  
Process Development ◽  
Development Stage ◽  
Solvent Selection ◽  
Pharmaceutical Manufacture ◽  
Selection For

A practicable, LCA based methodology has been developed to evaluate the sustainability implications of solvent selection during early process development for a batch manufacturing process for an API.

Process Development of an Inherently Safer Oxidation:  Synthesis of 2-Chloro-6-methylbenzoic Acid in the R411 Manufacturing Process

2005 ◽  
Vol 9 (6) ◽  
pp. 1003-1008 ◽  
Author(s):  
Flavio Chavez Lopez ◽  
Ashish Shankar ◽  
Maethonia Thompson ◽  
Brandon Shealy ◽  
Dobbert Locklear ◽  
...  
Keyword(s):  
Manufacturing Process ◽  
Process Development ◽  
Oxidation Synthesis

scholarly journals Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir

2021 ◽  
Author(s):  
Stephan M. Rummelt ◽  
Ji Qi ◽  
Yonggang Chen ◽  
James F. Dropinski ◽  
Gregory Hughes ◽  
...  
Keyword(s):  
Physical Properties ◽  
Building Block ◽  
Manufacturing Process ◽  
Process Development ◽  
Nucleoside Analog ◽  
Efficient Synthesis ◽  
Efficient Route ◽  
Acid Catalyzed ◽  
Initial Route ◽  
Nucleophile Addition

The unnatural, alkyne-containing nucleoside analog islatravir (MK-8591) is synthetically accessed through a biocatalytic cascade starting from 2-ethynylglycerol as a building block. Herein, we describe the development of an efficient synthesis of this building block including the initial route, route scouting and final process development. Key challenges that have been overcome are the development of an efficient and safe acetylenic nucleophile addition to an appropriate ketone, and the identification of a 2-ethynylpropane-1,2,3-triol derivative with favorable physical properties. An acid-catalyzed cracking of commercially available 1,3-dihydroxyacetone dimer and subsequent 1,2-addition of an acetylenic nucleophile has been discovered and optimized into the manufacturing process

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