Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis

2016 ◽  
Author(s):  
Seo Hyun Kim ◽  
Hana Lee ◽  
Dong Hyun Hwang ◽  
Dong Hyun Seo ◽  
Han Sung Kim ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Electrical Stimulation

scholarly journals Electrical stimulation for the treatment of rheumatoid arthritis

2002 ◽  
Author(s):  
Lucie Pelland ◽  
Lucie Brosseau ◽  
Lynn Casimiro ◽  
Vivian Welch ◽  
Peter Tugwell ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Electrical Stimulation

Abstract P184: Effects of Vagus Nerve Stimulation on Hemodynamics and Inflammation in a Rheumatoid Arthritis Model in Rats

Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Helio C Salgado ◽  
Daniel P Dias ◽  
Gabriel S Bassi ◽  
Alexandre Kanashiro ◽  
Thiago M Cunha
Keyword(s):  
Rheumatoid Arthritis ◽  
Electrical Stimulation ◽  
Vagus Nerve ◽  
Neutrophil Count ◽  
Inflammatory Responses ◽  
Bipolar Electrode ◽  
Neural Pathways ◽  
Anti Inflammatory ◽  
Stimulation Of ◽  
Inflammatory Effect

The electrical stimulation of neural pathways has been considered a reliable alternative for treating some pathophysiological conditions, for instance, rheumatoid arthritis. Recently, the concept of electroceuticals has emerged and suggests that proper anatomic mapping associated with identification of electrical stimulation patterns for each neural pathway would tailor this tool. The effects of electrical stimulation of the vagus nerve (VNS) on hemodynamics and inflammatory responses were assessed in a rheumatoid arthritis experimental model. Male Wistar rats (280 g body mass) were anesthetized (ketamine: 57 mg/kg; xylazine: 10 mg/kg) and instrumented with a polyethylene catheter into the femoral artery combined with a stainless steel bipolar electrode around the left vagus nerve. Animals were kept anesthetized and had the pulsatile arterial pressure recorded at baseline during 10 minutes, followed by a single session (2-minutes long) of VNS under three different conditions: A) 5 Hz, 0.1 ms, 1 V; B) 10 Hz, 0.1 ms, 1 V; and, C) 20 Hz; 0.1 ms; 3 V. Immediately after VNS ceased, rats were injected with zymosan (100 μg/50 μL) into the femorotibial joint to elicit rheumatoid arthritis. Rats were allowed to rest over the next six hours and afterwards were killed and had the synovial fluid collected for neutrophil count. Control rats were subjected to similar procedures but without VNS. The VNS condition A and B elicited a transitory bradycardia (A: 23±3, B: 23±2 Δbpm; as compared to baseline). No changes in blood pressure were seen following VNS at conditions A and B. VNS under C condition elicited pronounced transient bradycardia (101±13 Δbpm; as compared to baseline) and produced a transient hypotensive response (26±6 ΔmmHg, as compared to baseline). VNS at conditions A and B had anti-inflammatory effect showed by neutrophil count (A: -44±8, B: -38±7; percentage change as compared to control rats). However, VNS at C condition had no anti-inflammatory effect. Therefore, VNS was an effective anti-inflammatory tool that did not elicit remarkable hemodynamic alterations.

scholarly journals Association between psychosocial factors and dose of neuromuscular electrical stimulation in subjects with rheumatoid arthritis

2013 ◽  
Vol 34 (2) ◽  
pp. 57-66 ◽  
Author(s):  
Sara R. Piva ◽  
Stephanie Lasinski ◽  
Gustavo J.M. Almeida ◽  
G. Kelley Fitzgerald ◽  
Anthony Delitto
Keyword(s):  
Rheumatoid Arthritis ◽  
Electrical Stimulation ◽  
Psychosocial Factors ◽  
Neuromuscular Electrical Stimulation

scholarly journals Neuromuscular Electrical Stimulation Compared to Volitional Exercise for Improving Muscle Function in Rheumatoid Arthritis: A Randomized Pilot Study

2019 ◽  
Vol 71 (3) ◽  
pp. 352-361 ◽  
Author(s):  
Sara R. Piva ◽  
Samannaaz S. Khoja ◽  
Frederico G. S. Toledo ◽  
Mary Chester-Wasko ◽  
G. Kelley Fitzgerald ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Electrical Stimulation ◽  
Pilot Study ◽  
Muscle Function ◽  
Neuromuscular Electrical Stimulation

The “KIMWIPE” Effect in Ultra-Thin Cryosections

1985 ◽  
Vol 43 ◽  
pp. 458-459
Author(s):  
I. Taylor ◽  
P. Ingram ◽  
J.R. Sommer
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Muscle Fibers ◽  
Ice Crystals ◽  
Crystal Formation ◽  
Ice Crystal ◽  
Thin Sections ◽  
Skeletal Muscle Fibers ◽  
Freeze Dried ◽  
Ice Crystal Formation

In studying quick-frozen single intact skeletal muscle fibers for structural and microchemical alterations that occur milliseconds, and fractions thereof, after electrical stimulation, we have developed a method to compare, directly, ice crystal formation in freeze-substituted thin sections adjacent to all, and beneath the last, freeze-dried cryosections. We have observed images in the cryosections that to our knowledge have not been published heretofore (Figs.1-4). The main features are that isolated, sometimes large regions of the sections appear hazy and have much less contrast than adjacent regions. Sometimes within the hazy regions there are smaller areas that appear crinkled and have much more contrast. We have also observed that while the hazy areas remain still, the regions of higher contrast visibly contract in the beam, often causing tears in the sections that are clearly not caused by ice crystals (Fig.3, arrows).

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