scholarly journals Predicting beta bursts from local field potentials to improve closed-loop DBS paradigms in Parkinson’s patients

2018 ◽  
Author(s):  
Eduardo Martin Moraud ◽  
Gerd Tinkhauser ◽  
Mayank Agrawal ◽  
Peter Brown ◽  
Rafal Bogacz
Keyword(s):  
Local Field ◽  
Closed Loop ◽  
Local Field Potentials ◽  
Field Potentials

scholarly journals 2327 Decoding/encoding somatosensation from the hand area of the human primary somatosensory (S1) cortex for a closed-loop motor/sensory brain-machine interface (BMI)

2018 ◽  
Vol 2 (S1) ◽  
pp. 8-8
Author(s):  
Brian Lee ◽  
Richard Andersen ◽  
Helena Chui ◽  
William Mack
Keyword(s):  
Local Field ◽  
Closed Loop ◽  
Local Field Potentials ◽  
Injured Patient ◽  
Brain Machine Interface ◽  
Field Potentials ◽  
Initial Surgery ◽  
Cord Injury ◽  
Machine Interface ◽  
The Brain

OBJECTIVES/SPECIFIC AIMS: A brain-machine interface (BMI) is a device implanted into the brain of a paralyzed or injured patient to control an external assistive device, such as a cursor on a computer screen, a motorized wheelchair, or a robotic limb. We hypothesize we can utilize electrical stimulation of subdural electrocorticography (ECoG) electrodes as a method of generating the percepts of somatosensation such as vibration, temperature, or proprioception. METHODS/STUDY POPULATION: There will be 10 subjects, who are informed, willing, and consented epilepsy patients undergoing initial surgery for placement of subdural ECoG electrodes in the brain for seizure monitoring. ECoG will be used as a platform for recording high-resolution local field potentials during real-touch behavioral tasks. In addition, ECoG will also be used to electrically stimulate the human cerebral cortex in order to map and understand how varying stimulation parameters produce percepts of sensation. RESULTS/ANTICIPATED RESULTS: To determine how tactile and proprioceptive signals are integrated in S1, we will perform spectral analysis of the broadband local field potentials to look for increased power in specific frequency bands in the ECoG recordings while touching or moving the hand. To explore generating artificial sensation, the subject will be asked to perform a variety of tasks with and without the aid of stimulation. We anticipate the subject’s performance will be enhanced with the addition of artificial sensation. DISCUSSION/SIGNIFICANCE OF IMPACT: Many patients might benefit from a BMI, such as those with stroke, amputation, spinal cord injury, or brain trauma. The current generation of BMI devices are guided by visual feedback alone. However, without somatosensory feedback, even the most basic limb movements are difficult to perform in a fluid and natural manner. The results from this project will be crucial to developing a closed loop motor/sensory BMI.

scholarly journals Closed‐Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials

2021 ◽  
Vol 36 (4) ◽  
pp. 863-873
Author(s):  
Shenghong He ◽  
Fahd Baig ◽  
Abteen Mostofi ◽  
Alek Pogosyan ◽  
Jean Debarros ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Local Field ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Local Field Potentials ◽  
Field Potentials ◽  
Deep Brain

scholarly journals Bilateral double beta peaks in a PD patient with STN electrodes

2020 ◽  
Vol 163 (1) ◽  
pp. 205-209 ◽  
Author(s):  
Thomas Koeglsperger ◽  
Jan H. Mehrkens ◽  
Kai Bötzel
Keyword(s):  
Physical Activity ◽  
Deep Brain Stimulation ◽  
Local Field ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Local Field Potentials ◽  
Beta Activity ◽  
Field Potentials ◽  
Beta Band ◽  
Deep Brain

AbstractSubthalamic local field potentials in the beta band are considered as potential biomarkers for closed-loop deep brain stimulation. To investigate the subthalamic beta band peak amplitudes in a Parkinson’s disease patient over an extended period of time by using a novel and commercially available neurostimulator with permanent sensing capability. We recorded local field potentials of the subthalamic nucleus using the Medtronic Percept™ implantable neurostimulator at rest and during physical activity (gait) with and in response to deep brain stimulation. We found a double-peaked beta activity on both sides. Increasing stimulation and physical activity resulted in a decreased beta band amplitude, but was accompanied by the appearance of a second, and previously unrecognized peak at 13 Hz in the right hemisphere. Our results will support the investigation of distinct different peaks in the beta band and their relevance and usefulness as closed-loop biomarkers.

scholarly journals Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy

2021 ◽  
Vol 11 (7) ◽  
pp. 882
Author(s):  
Yeon Hee Yu ◽  
Seong-Wook Kim ◽  
Dae-Kyoon Park ◽  
Ho-Yeon Song ◽  
Duk-Soo Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Local Field ◽  
Smooth Muscle Actin ◽  
Local Field Potentials ◽  
Renal Tissue ◽  
Field Potentials ◽  
Wild Type ◽  
Sprague Dawley ◽  
Rat Models

Increased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are serious concerns in patients with CKD. However, the relevance of CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Male Sprague Dawley rats were divided into three groups: sham control, 5/6 nephrectomy at 4 weeks, and 5/6 nephrectomy at 10 weeks. Behavior tests, local field potentials, and histology and laboratory tests were conducted and investigated. We provided direct evidence showing that CKD rat models exhibited anxiogenic behaviors and depression-like phenotypes, along with altered hippocampal neural oscillations at 1–12 Hz. We generated CKD rat models by performing 5/6 nephrectomy, and identified higher level of serum creatinine and blood urea nitrogen (BUN) in CKD rats than in wild-type, depending on time. In addition, the level of α-smooth muscle actin (α-SMA) and collagen I for renal tissue was markedly elevated, with worsening fibrosis due to renal failures. The level of anxiety and depression-like behaviors increased in the 10-week CKD rat models compared with the 4-week rat models. In the recording of local field potentials, the power of delta (1–4 Hz), theta (4–7 Hz), and alpha rhythm (7–12 Hz) was significantly increased in the hippocampus of CKD rats compared with wild-type rats. Together, our findings indicated that anxiogenic behaviors and depression can be induced by CKD, and these abnormal symptoms can be worsened as the onset of CKD was prolonged. In conclusion, our results show that the hippocampus is vulnerable to uremia.

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