Evaluation of lung ventilation distribution in chronic obstructive pulmonary disease patients using the global inhomogeneity index

2016 ◽  
Author(s):  
F. Trenk ◽  
L. Mendes ◽  
P. Carvalho ◽  
R. P. Paiva ◽  
J. Henriques ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Lung Ventilation ◽  
Chronic Obstructive ◽  
Ventilation Distribution ◽  
Obstructive Pulmonary Disease ◽  
Inhomogeneity Index

Two-Lung and One-Lung Ventilation in Patients with Chronic Obstructive Pulmonary Disease: The Effects of Position and FIO2

2000 ◽  
Vol 90 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Gizella I. Bardoczky ◽  
Laszlo L. Szegedi ◽  
Alain A. d’Hollander ◽  
Jean-Marie Moures ◽  
Philippe de Francquen ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Lung Ventilation ◽  
Chronic Obstructive ◽  
One Lung Ventilation ◽  
Obstructive Pulmonary Disease

scholarly journals Regional lung response to bronchodilator reversibility testing determined by electrical impedance tomography in chronic obstructive pulmonary disease

2016 ◽  
Vol 311 (1) ◽  
pp. L8-L19 ◽  
Author(s):  
Barbara Vogt ◽  
Zhanqi Zhao ◽  
Peter Zabel ◽  
Norbert Weiler ◽  
Inéz Frerichs
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Tidal Volume ◽  
Pulmonary Disease ◽  
Electrical Impedance Tomography ◽  
Electrical Impedance ◽  
Chronic Obstructive ◽  
Ventilation Distribution ◽  
Prognostic Information ◽  
Impedance Tomography ◽  
Obstructive Pulmonary Disease

Patients with obstructive lung diseases commonly undergo bronchodilator reversibility testing during examination of their pulmonary function by spirometry. A positive response is defined by an increase in forced expiratory volume in 1 s (FEV1). FEV1 is a rather nonspecific criterion not allowing the regional effects of bronchodilator to be assessed. We employed the imaging technique of electrical impedance tomography (EIT) to visualize the spatial and temporal ventilation distribution in 35 patients with chronic obstructive pulmonary disease at baseline and 5, 10, and 20 min after bronchodilator inhalation. EIT scanning was performed during tidal breathing and forced full expiration maneuver in parallel with spirometry. Ventilation distribution was determined by EIT by calculating the image pixel values of FEV1, forced vital capacity (FVC), tidal volume, peak flow, and mean forced expiratory flow between 25 and 75% of FVC. The global inhomogeneity indexes of each measure and histograms of pixel FEV1/FVC values were then determined to assess the bronchodilator effect on spatial ventilation distribution. Temporal ventilation distribution was analyzed from pixel values of times needed to exhale 75 and 90% of pixel FVC. Based on spirometric FEV1, significant bronchodilator response was found in 17 patients. These patients exhibited higher postbronchodilator values of all regional EIT-derived lung function measures in contrast to nonresponders. Ventilation distribution was inhomogeneous in both groups. Significant improvements were noted for spatial distribution of pixel FEV1 and tidal volume and temporal distribution in responders. By providing regional data, EIT might increase the diagnostic and prognostic information derived from reversibility testing.

scholarly journals The influence of non-invasive lung ventilation on functional and immune characteristics in patients with severe exacerbation of chronic obstructive pulmonary disease

2017 ◽  
Vol 95 (4) ◽  
pp. 344-349
Author(s):  
E. V. Makarova ◽  
S. V. Shumilova ◽  
V. A. Vakhlamov ◽  
E. S. Kasatova ◽  
N. V. Men’kov ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Lung Ventilation ◽  
Control Group ◽  
Chronic Obstructive ◽  
Severe Exacerbation ◽  
Obstructive Pulmonary Disease ◽  
Non Invasive ◽  
Systemic Corticosteroids ◽  
Immunosuppressive Action

We studied the influence of spontaneous/timed non-invasive ventilation (NIV) on the functional and immune characteristics of patients with severe exacerbation of chronic obstructive pulmonary disease (COPD). Symptoms, pulmonary function test, O2 saturation (SpO2) were investigated; serum content of soluble differentiated leukocyte molecules was measured using ELISA. NIV led to a more significant improvement of general state, dyspnea, and respiratory function in comparison with the control group, increased SpO2, and decreased initially elevated concentrations of soluble sCD95, sCD50, sCD16 molecules reflecting the reduction of inflammatory activation of immune cells. The use of NIV allowed to lower the doses of systemic corticosteroids that caused inhibition of 6 out of 13 studied soluble antigens in the control group (oligomeric and total sCD95, total sCD38, sCD25, sCD50, sHLA-DR) due to non-selective immunosuppressive action. This procedure may be recommended for a wider use in pulmonological practice.

scholarly journals The effect of Pursed Lips Breathing Exercises on the Oxygen Saturation Levels of Patients with Chronic Obstructive Pulmonary Disease in Persahabatan Hospital, Jakarta

2021 ◽  
pp. 35-64
Author(s):  
. Sumedi ◽  
Koshy Philip ◽  
Muhammad Hafizurrachman
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oxygen Saturation ◽  
Pulmonary Disease ◽  
Intervention Group ◽  
Lung Ventilation ◽  
Control Group ◽  
Chronic Obstructive ◽  
Breathing Exercise ◽  
Obstructive Pulmonary Disease ◽  
Breathing Exercises

Patients with chronic obstructive pulmonary disease can face increased resistance of airflow, air trapping, and lung hyperinflation. This condition can also cause decreased lung ventilation functions. Using a pursed lips breathing exercise can strengthen respiratory muscles that can improve oxygen saturation by maintaining airflow to bronchus and its branches and alveolus which then can prevent collapse in bronchiolus. The purpose of the study was to identify the effect of pursed lips breathing exercises on the oxygen saturation levels in patients with chronic obstructive lung disease in Persahabatan hospital, Jakarta. The design was quasi experimental, with a control group pre-post test design. A random sampling technique was used in the study. The exercise was provided to the intervention group for six days. The findings showed that the lung ventilation function is significantly different between preand post-intervention for both groups (p=0.00). Further, the average lung ventilation function in the intervention group is significantly different from that of the control group after intervention (p=0.012). In addition, while there is a significant relationship between subject age and the increase of the lung ventilation score (p=0.001), there was no relationship between height and the increase of oxygen saturation (p=0.091) and no significant relationship between sex and the increase of oxygen saturation (p=0.346). Based on these findings, the pursed lips breathing exercise is recommended to patients with chronic obstructive lung disease in order to improve the level of oxygen saturation.   Keywords: Oxygen saturation, Pursed lips breathing exercise, Chronic Obstructive Pulmonary Disease.

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

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