Effects of propofol anesthesia induction on the relationship between arterial blood pressure and heart rate

Author(s):  
G. Dorantes-Mendez ◽  
F. Aletti ◽  
N. Toschi ◽  
M. Guerrisi ◽  
F. Coniglione ◽  
...  
Author(s):  
Dileep Kumar ◽  
Kamal Kumar ◽  
Mohammad Hamid

Objective: To compare efficacy of intravenous paracetamol and fentanyl for intra-operative and post-operative analgesia in patients undergoing for diagnostic and therapeutic rigid hysteroscopy. Methods: Prospective Randomized Clinical Trial was conducted at Aga Khan University Hospital, Karachi, from October 2016 to June 2017. Study instituted after ethical review committee approval and patient has ASA-I, II, aged 18-65 years, consented for hysteroscopy. Anesthesia induction technique was standardized and analgesia in group-P, paracetamol 15 mg/Kg administered 15-30 minutes before surgery and in group-F, fentanyl 2 mcg/kg administered at induction of anesthesia. Intraoperative pain was assessed by changes in heart rate, systolic, diastolic and mean arterial blood pressure and postoperative pain was assessed by visual analogue scale. SPSS 19 was used for data analysis. Results: Sixty patients scheduled for hysteroscopy were allocated into two groups. Patient’s ASA status and demographics were found relatively similar in both groups except for age differences (p< 0.011). In paracetamol group, mean SBP at 10,15, 20, 25 and 30 minutes and mean DBP at 20, 25 minutes & Mean arterial blood pressure at 20 minutes were statistically significant (p<0.05) compared to the fentanyl group. However, the mean heart rate was statistically insignificant among the groups. The postoperative visual analogue pain scores were almost similar at 0, 15, and 30 minutes (p>0.05) among the groups. Although, the rescue analgesia was needed in 3 patients on arrival in recovery room in each group. Conclusion: Intravenous paracetamol offers similar analgesic efficacy to fentanyl for rigid hysteroscopy in ambulatory surgery. However, Continuous...


2002 ◽  
Vol 283 (5) ◽  
pp. R1221-R1226 ◽  
Author(s):  
Jian Cui ◽  
Thad E. Wilson ◽  
Craig G. Crandall

To test the hypothesis that phenylephrine-induced elevations in blood pressure are attenuated in heat-stressed humans, blood pressure was elevated via steady-state infusion of three doses of phenylephrine HCl in 10 healthy subjects in both normothermic and heat stress conditions. Whole body heating significantly increased sublingual temperature by ∼0.5°C, muscle sympathetic nerve activity (MSNA), heart rate, and cardiac output and decreased total peripheral vascular resistance (TPR; all P < 0.005) but did not change mean arterial blood pressure (MAP; P > 0.05). At the highest dose of phenylephrine, the increase in MAP and TPR from predrug baselines was significantly attenuated during the heat stress [ΔMAP 8.4 ± 1.2 mmHg; ΔTPR 0.96 ± 0.85 peripheral resistance units (PRU)] compared with normothermia (ΔMAP 15.4 ± 1.4 mmHg, ΔTPR 7.13 ± 1.18 PRU; all P < 0.001). The sensitivity of baroreflex control of MSNA and heart rate, expressed as the slope of the relationship between MSNA and diastolic blood pressure, as well as the slope of the relationship between heart rate and systolic blood pressure, respectively, was similar between thermal conditions (each P > 0.05). These data suggest that phenylephrine-induced elevations in MAP are attenuated in heat-stressed humans without affecting baroreflex control of MSNA or heart rate.


1986 ◽  
Vol 251 (3) ◽  
pp. H612-H618 ◽  
Author(s):  
D. N. Darlington ◽  
J. Shinsako ◽  
M. F. Dallman

Hemorrhages of various magnitudes were performed on conscious rats, and arterial pressure, heart rate, and plasma levels of adrenocorticotropin hormone (ACTH), epinephrine, and norepinephrine were measured. Eight rats were prepared with chronic femoral arterial cannulas and received a 10, 15, or 20 ml/kg X 3 min hemorrhage in random order on day 4, 7, or 10 after surgery. Mean arterial blood pressure, heart rate, and plasma ACTH, epinephrine, and norepinephrine concentrations were determined before and 20 min after hemorrhage. Arterial blood pressure decreased significantly immediately after each hemorrhage and slowly recovered over the next 20 min. Heart rate did not change during the 10 ml/kg X 3 min hemorrhage but decreased significantly after 15 and 20 ml/kg X 3 min hemorrhages. Plasma ACTH and epinephrine levels increased significantly 20 min after the 15 and 20 ml/kg X 3 min hemorrhages but not after 10 ml/kg X 3 min hemorrhage. Norepinephrine increased significantly 20 min after the 20 ml/kg X 3 min hemorrhage but not after the 10 or 15 ml/kg X 3 min hemorrhage. There was no significant effect of time and repeated hemorrhages on resting levels of plasma ACTH, epinephrine, norepinephrine, osmolality, or proteins. Since hemorrhage leads to a fall in arterial pressure and a subsequent rise in plasma ACTH, the relationship between plasma ACTH and mean arterial blood pressure during hemorrhage was examined in both conscious and acutely prepared pentobarbital sodium-anesthetized rats.(ABSTRACT TRUNCATED AT 250 WORDS)


2014 ◽  
Vol 63 (6) ◽  
pp. 435-438 ◽  
Author(s):  
Kunihiko Tanaka ◽  
Shiori Tokumiya ◽  
Yumiko Ishihara ◽  
Yumiko Kohira ◽  
Tetsuro Katafuchi

2021 ◽  
pp. 1-8
Author(s):  
Yi-Tse Hsiao ◽  
Yun-Wen Peng ◽  
Pin Huan Yu

Monitoring blood pressure helps a clinical veterinarian assess various conditions in birds. Blood pressure is not only a bio-indicator of renal or cardiovascular disease but is also a vital indicator for anesthesia. Anesthetic- and sedation-related mortality is higher in birds than dogs or cats. The traditional method of blood pressure measurement in mammals mainly relies on indirect methods. However, indirect blood pressure measurement is not reliable in birds, making the direct method the only gold standard. Although an arterial catheter can provide continuous real-time arterial pressure in birds, the method requires technical skill and is limited by bird size, and is thus not practical in birds with circulatory collapse. Intra-osseous (IO) blood pressure is potentially related to arterial pressure and may be a much easier and safer technique that is less limited by animal size. However, the relationship between IO pressure and arterial blood pressure has not been established. This study used mathematical methods to determine the relationship between IO pressure and arterial blood pressure. The Granger causality (G.C.) theory was applied in the study and used to analyze which pressure signal was leading the other. Our findings suggest that IO pressure is G.C. by arterial blood pressure; thus, the use of IO pressure measurements as an alternative to arterial blood pressure measurement is a rational approach.


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