An influence of spontaneous spike rates on information transmission in a spherical bushy neuron model with stochastic ion channels

2012 ◽  
Author(s):  
H. Arata ◽  
H. Mino
Keyword(s):  
Ion Channels ◽  
Information Transmission ◽  
Neuron Model ◽  
Stochastic Ion Channels

A Simplified Neuronal Model for the Instigation and Propagation of Cortical Spreading Depression

2011 ◽  
Vol 3 (6) ◽  
pp. 759-773 ◽  
Author(s):  
Huaxiong Huang ◽  
Robert M. Miura ◽  
Wei Yao
Keyword(s):  
Ion Channels ◽  
Network Model ◽  
Cortical Spreading Depression ◽  
Single Neuron ◽  
Neuron Model ◽  
Spreading Depression ◽  
Neuronal Model

AbstractIn this paper, we construct a simplified neuronal model that is capable of simulating the instigation of cortical spreading depression (CSD) and propagation of a CSD wave. Our model is a simplification and extension of a single neuron model proposed in the literature for studying the instigation of CSD. Using the simplified neuronal model, we construct a network of these simplified neurons. This network model shows that the propagation of a CSD wave occurs naturally after it is instigated electrically or chemically. Although the model is simple, the speed of the CSD wave predicted by our model is consistent with experimentally observed values. Finally, our model allows us to investigate the effects of specific ion channels on the spread of a CSD wave.

Formation of multi-armed spiral waves in neuronal network induced by adjusting ion channel conductance

2015 ◽  
Vol 29 (07) ◽  
pp. 1550043 ◽  
Author(s):  
Chunni Wang ◽  
Jun Ma ◽  
Bolin Hu ◽  
Wuyin Jin
Keyword(s):  
Ion Channels ◽  
Neuron Model ◽  
Nearest Neighbor ◽  
Spiral Wave ◽  
Spiral Waves ◽  
Channel Conductance ◽  
Transient Period ◽  
Regular Network ◽  
Realistic Neuron ◽  
Armed Spiral

The Hodgkin–Huxley neuron model is used to describe the local dynamics of nodes in a two-dimensional regular network with nearest-neighbor connections. Multi-armed spiral waves emerge when a group of spiral waves rotate the same core synchronously. Here we have numerically investigated how multi-armed spiral waves are formed in such a system. Under the appropriate conditions, multi-armed spiral waves were able to develop as a result of adjusting the conductance of ion channels of particular neurons in the network. In a realistic neuron model, it can be practiced by blocking potassium of ion channels embedded in the membrane of neurons. For example, decreasing the potassium channel conductance in some neurons with a certain transient period can lead to the development of a group of double spirals in a localized area of the network. Furthermore, decreasing the excitability and the external forcing current to zero led to the growth of these double spirals and the formation of a stable multi-armed spiral wave that occupied the network under inhomogeneity.

Spike propagation in dendrites with stochastic ion channels

2006 ◽  
Vol 20 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Kamran Diba ◽  
Christof Koch ◽  
Idan Segev
Keyword(s):  
Ion Channels ◽  
Stochastic Ion Channels
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