Aptamer-NASBA LOC as a prospective tool for systemic therapy of cancer: Quantitative detection on signaling molecular profiling

2012 ◽  
Author(s):  
Xinyan Zhao ◽  
Tao Dong ◽  
Zhaochu Yang ◽  
H. Karlsen
Keyword(s):  
Systemic Therapy ◽  
Molecular Profiling ◽  
Quantitative Detection

8: Tumour molecular profiling and quantitative detection of circulating biomarkers in patients with lung cancer

Lung Cancer ◽  
2015 ◽  
Vol 87 ◽  
pp. S3-S4 ◽  
Author(s):  
E. Karampini ◽  
H. Farah ◽  
G. Mills ◽  
N. Kamal ◽  
K. Tobal ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Molecular Profiling ◽  
Quantitative Detection ◽  
Circulating Biomarkers

scholarly journals Current Status and Future Targeted Therapy in Adrenocortical Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
George Alyateem ◽  
Naris Nilubol
Keyword(s):  
Systemic Therapy ◽  
Treatment Options ◽  
Molecular Profiling ◽  
Current Treatment ◽  
Current Status ◽  
Adrenocortical Cancer ◽  
Treatment Standards ◽  
Molecular Alterations ◽  
Complete Surgical Resection ◽  
Rare Malignancy

Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. The current treatment standards include complete surgical resection for localized resectable disease and systemic therapy with mitotane alone or in combination with etoposide, doxorubicin, and cisplatin in patients with advanced ACC. However, the efficacy of systemic therapy in ACC is very limited, with high rates of toxicities. The understanding of altered molecular pathways is critically important to identify effective treatment options that currently do not exist. In this review, we discuss the results of recent advanced in molecular profiling of ACC with the focus on dysregulated pathways from various genomic and epigenetic dysregulation. We discuss the potential translational therapeutic implication of molecular alterations. In addition, we review and summarize the results of recent clinical trials and ongoing trials.

scholarly journals Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols

RSC Advances ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1479-1485
Author(s):  
Ben. J. Tickner ◽  
Sanna Komulainen ◽  
Sanna Palosaari ◽  
Janne Heikkinen ◽  
Petri Lehenkari ◽  
...  
Keyword(s):  
Molecular Profiling ◽  
Electronic Cigarette ◽  
Quantitative Detection ◽  
Low Concentration ◽  
Nmr Signals

SABRE hyperpolarisation enhances NMR signals of low concentration nicotine and acrolein and allows quantitative detection in electronic cigarette aerosol solutions.

Supportive, Systemic Therapy Key for TEN, SJS

2006 ◽  
Vol 37 (10) ◽  
pp. 36-37
Author(s):  
NANCY WALSH
Keyword(s):  
Systemic Therapy

Systemic therapy of metastatic melanoma

1999 ◽  
Vol 56 (6) ◽  
pp. 330-333
Author(s):  
Dummer ◽  
Nestle ◽  
Hofbauer ◽  
Burg
Keyword(s):  
Metastatic Melanoma ◽  
Systemic Therapy ◽  
Interleukin 2 ◽  
Kurative Therapie

Das metastasierende Melanom (MM) gehört zu den schwierig behandelbaren Malignomen, wobei Allgemeinzustand und Motivation des Patienten neben Zahl und Lokalisation der Metastasen das therapeutische Vorgehen bestimmen. Solitäre Metastasen in Lunge, ZNS, Weichteilen und Lymphknoten sollten primär chirurgisch entfernt werden. Multiple Metastasen, insbesondere abdominal, werden nur in Ausnahmefällen chirurgisch angegangen. Hier ist vielmehr ein systemische Chemoimmuntherapie angebracht. Aussichtsreiche Behandlungskonzepte beinhalten Interleukin-2, Interferon, und verschiedenen Zytostatika wie DTIC, Temozolamid, Vindesine oder Cisplatin. Bei ZNS- und Skelettfiliae ist die Radiotherapie einzusetzen. Durch diese Chemoimmuntherapien hat sich die Prognose des metastasierenden Melanoms bezüglich des Überlebens verbessert. Langfristig wird aber nur eine Kombination von zeitraubenden Multicenterstudien und experimentellen Ansätzen in der Lage sein, uns langsam an eine kurative Therapie heranzuführen.

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