Accelerating functional verification of PCI express endpoint by emulating host system using PCI express core

2014 ◽  
Author(s):  
Shreeya Badhe ◽  
Kedar Kulkarni ◽  
Geetanjali Gadre
Keyword(s):  
Functional Verification ◽  
Pci Express ◽  
Host System

The SNPs within 3'UTR of miRNA Target Genes Related to Multiple Sclerosis: A Computational Prediction

2020 ◽  
Vol 17 (2) ◽  
pp. 133-147
Author(s):  
Mina Zafarpiran ◽  
Roya Sharifi ◽  
Zeinab Shirvani-Farsani
Keyword(s):  
Multiple Sclerosis ◽  
Gene Regulation ◽  
Binding Sites ◽  
Target Genes ◽  
Demyelinating Disease ◽  
Target Prediction ◽  
Computational Prediction ◽  
Functional Verification ◽  
Candidate Snps ◽  
Inflammatory Genes

Background: Multiple Sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system, and genetic factors play an important role in its susceptibility. The expressions of many inflammatory genes implicated in MS are regulated by microRNA (miRNAs), whose function is to suppress the translation by pairing with miRNA Recognition Elements (MREs) present in the 3' untranslated region (3'UTR) of target mRNA. Recently, it has been shown that the Single Nucleotide Polymorphism (SNPs) present within the 3'UTR of mRNAs can affect the miRNA-mediated gene regulation and susceptibility to a variety of human diseases. Objective: The aim of this study was to analyze the SNPs within the 3'UTR of miRNA inflammatory target genes related to multiple sclerosis. Methods: By DisGeNET, dbGaP, Ovid, DAVID, Web of knowledge, and SNPs databases, 3'UTR genetic variants were identified in all inflammatory genes associated with MS. Also, miRNA's target prediction databases were used for predicting the miRNA binding sites. Results: We identified 125 SNPs with MAF>0.05 located in the binding site of the miRNA of 35 genes among 59 inflammatory genes related to MS. Bioinformatics analysis predicted 62 MRE-modulating SNPs and 59 MRE-creating SNPs in the 3'UTR of MSimplicated inflammatory genes. These candidate SNPs within miRNA binding sites of inflammatory genes can alter the miRNAs binding, and consequently lead to the mRNA gene regulation. Conclusion: Therefore, these miRNA and MRE-SNPs may play important roles in personalized medicine of MS, and hence, they would be valuable for further functional verification investigations.

Serum neutralization of feline immunodeficiency virus is markedly dependent on passage history of the virus and host system.

1994 ◽  
Vol 68 (7) ◽  
pp. 4572-4579 ◽  
Author(s):  
F Baldinotti ◽  
D Matteucci ◽  
P Mazzetti ◽  
C Giannelli ◽  
P Bandecchi ◽  
...  
Keyword(s):  
Feline Immunodeficiency Virus ◽  
Host System ◽  
Serum Neutralization ◽  
Immunodeficiency Virus ◽  
History Of

scholarly journals Design and Performance Study for Electrothermally Deep-Sea Drive Microunits Using a Paraffin Phase Change Material

Micromachines ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 415
Author(s):  
Dayong Ning ◽  
Zihao Li ◽  
Gangda Liang ◽  
Qibo Wang ◽  
Weifeng Zou ◽  
...  
Keyword(s):  
Phase Change ◽  
Phase Change Material ◽  
Deep Sea ◽  
Hydraulic System ◽  
Functional Verification ◽  
Performance Study ◽  
Micro Electro Mechanical Systems ◽  
Pressure Compensation ◽  
And Performance ◽  
Change Material

Considering the further exploration of the ocean, the requirements for deep-sea operation equipment have increased. Many problems existing in the widely used deep-sea hydraulic system have become increasingly prominent. Compared with the traditional deep-sea hydraulic system, actuators using a paraffin phase change material (PCM) have incomparable advantages, including lightweight structure, low energy consumption, high adaptability to the deep sea, and good biocompatibility. Thus, a deep-sea drive microunit (DDM) based on paraffin PCM is proposed in this paper. The device adopts a flexible shell, adapting to the high-pressure environment of the deep-sea based on the principle of pressure compensation. The device realizes the output of displacement and force through the electrothermal drive, which can be used as actuator or power source of other underwater operation equipment. The microunit successfully completes the functional verification experiments in air, shallow water, and hydrostatic pressure of 110 MPa. In accordance with experimental results, a reasonable control curve is fitted, highlighting its potential application in deep-sea micro electro mechanical systems, especially in underwater soft robot.

scholarly journals Experimental CanSat Platform for Functional Verification of Burn Wire Triggering-Based Holding and Release Mechanisms

Aerospace ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 192
Author(s):  
Shankar Bhattarai ◽  
Ji-Seong Go ◽  
Hyun-Ung Oh
Keyword(s):  
Functional Performance ◽  
Flight Test ◽  
Easy Access ◽  
Functional Verification ◽  
Release Mechanism ◽  
Space Technology ◽  
Solar Panels ◽  
Distinctive Features ◽  
Release Mechanisms ◽  
Design Effectiveness

In this study, we present the Diverse Holding and Release Mechanism Can Satellite (DHRM CanSat) platform developed by the Space Technology Synthesis Laboratory (STSL) at Chosun University, South Korea. This platform focuses on several types of holding and release mechanisms (HRMs) for application in deployable appendages of nanosatellites. The objectives of the DHRM CanSat mission are to demonstrate the design effectiveness and functionality of the three newly proposed HRMs based on the burn wire triggering method, i.e., the pogo pin-type HRM, separation nut-type HRM, and Velcro tape-type HRM, which were implemented on deployable dummy solar panels of the CanSat. The proposed mechanisms have many advantages, including a high holding capability, simultaneous constraints in multi-plane directions, and simplicity of handling. Additionally, each mechanism has distinctive features, such as spring-loaded pins to initiate deployment, a plate with a thread as a nut for a high holding capability, and a hook and loop fastener for easy access to subsystems of the satellite without releasing the holding constraint. The design effectiveness and functional performance of the proposed mechanisms were demonstrated through an actual flight test of the DHRM CanSat launched by a model rocket.

scholarly journals A 1.93-pJ/Bit PCI Express Gen4 PHY Transmitter with On-Chip Supply Regulators in 28 nm CMOS

Electronics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 68
Author(s):  
Woorham Bae ◽  
Sung-Yong Cho ◽  
Deog-Kyoon Jeong
Keyword(s):  
Finite Impulse Response ◽  
Cmos Process ◽  
Pci Express ◽  
Fully Integrated ◽  
Peripheral Component Interconnect ◽  
Low Power Cmos ◽  
On Chip ◽  
Output Driver ◽  
Wide Operating ◽  
28 Nm

This paper presents a fully integrated Peripheral Component Interconnect (PCI) Express (PCIe) Gen4 physical layer (PHY) transmitter. The prototype chip is fabricated in a 28 nm low-power CMOS process, and the active area of the proposed transmitter is 0.23 mm2. To enable voltage scaling across wide operating rates from 2.5 Gb/s to 16 Gb/s, two on-chip supply regulators are included in the transmitter. At the same time, the regulators maintain the output impedance of the transmitter to meet the return loss specification of the PCIe, by including replica segments of the output driver and reference resistance in the regulator loop. A three-tap finite-impulse-response (FIR) equalization is implemented and, therefore, the transmitter provides more than 9.5 dB equalization which is required in the PCIe specification. At 16 Gb/s, the prototype chip achieves energy efficiency of 1.93 pJ/bit including all the interface, bias, and built-in self-test circuits.

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