Optical biopsy needle for optical coherence tomography

Author(s):  
X. Li ◽  
T. Ko ◽  
C. Pitris ◽  
J.G. Fujimoto
2021 ◽  
Vol 11 (7) ◽  
pp. 3119
Author(s):  
Cristina L. Saratxaga ◽  
Jorge Bote ◽  
Juan F. Ortega-Morán ◽  
Artzai Picón ◽  
Elena Terradillos ◽  
...  

(1) Background: Clinicians demand new tools for early diagnosis and improved detection of colon lesions that are vital for patient prognosis. Optical coherence tomography (OCT) allows microscopical inspection of tissue and might serve as an optical biopsy method that could lead to in-situ diagnosis and treatment decisions; (2) Methods: A database of murine (rat) healthy, hyperplastic and neoplastic colonic samples with more than 94,000 images was acquired. A methodology that includes a data augmentation processing strategy and a deep learning model for automatic classification (benign vs. malignant) of OCT images is presented and validated over this dataset. Comparative evaluation is performed both over individual B-scan images and C-scan volumes; (3) Results: A model was trained and evaluated with the proposed methodology using six different data splits to present statistically significant results. Considering this, 0.9695 (±0.0141) sensitivity and 0.8094 (±0.1524) specificity were obtained when diagnosis was performed over B-scan images. On the other hand, 0.9821 (±0.0197) sensitivity and 0.7865 (±0.205) specificity were achieved when diagnosis was made considering all the images in the whole C-scan volume; (4) Conclusions: The proposed methodology based on deep learning showed great potential for the automatic characterization of colon polyps and future development of the optical biopsy paradigm.


Author(s):  
R. Wessels ◽  
D. M. De Bruin ◽  
D. J. Faber ◽  
T. G. Van Leeuwen ◽  
M. Van Beurden ◽  
...  

2001 ◽  
Author(s):  
Wolfgang Drexler ◽  
Ravi K. Ghanta ◽  
Joel S. Schuman ◽  
Tony H. Ko ◽  
Uwe Morgner ◽  
...  

2014 ◽  
Vol 79 (5) ◽  
pp. AB181
Author(s):  
Vani J. Konda ◽  
Ann Koons ◽  
Uzma D. Siddiqui ◽  
Shu-Yuan Xiao ◽  
Jerrold R. Turner ◽  
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2012 ◽  
Vol 20 (11) ◽  
pp. 3685-3693 ◽  
Author(s):  
Renu John ◽  
Steven G. Adie ◽  
Eric J. Chaney ◽  
Marina Marjanovic ◽  
Krishnarao V. Tangella ◽  
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1997 ◽  
Vol 71 (1) ◽  
pp. 32-40 ◽  
Author(s):  
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Gary J. Tearney ◽  
Stephen A. Boppart ◽  
Eric A. Swanson ◽  
James F. Southern ◽  
...  

2018 ◽  
pp. 217-237
Author(s):  
Prashanth Panta ◽  
Chih-Wei Lu ◽  
Piyush Kumar ◽  
Tuan-Shu Ho ◽  
Sheng-Lung Huang ◽  
...  

2019 ◽  
Vol 24 (02) ◽  
pp. 1
Author(s):  
Judith Lindert ◽  
Kianusch Tafazzoli-Lari ◽  
Ludger Tüshaus ◽  
Beke Larsen ◽  
Anna Bacia ◽  
...  

Neoplasia ◽  
2000 ◽  
Vol 2 (1-2) ◽  
pp. 9-25 ◽  
Author(s):  
James G. Fujimoto ◽  
Costas Pitris ◽  
Stephen A. Boppart ◽  
Mark E. Brezinski

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