OpenGL is an excellent tool for developing 3D graphics. Because of its language based on C language, the documents which about OpenGL application in VB are very scarce currently. This article uses a 3D experimental model developed by OpenGL in VB environment as example, to introduce how to set up OpenGL framework in VB, and how to draw 3D graphics and implement interact, how to use the transformation matrix to control the transformations of 3D graphics, to provide some experiences and methods for VB programmers.